Macrophage “activation” is a complex process with limited knowledge of its regulation or variable expression in different tissues and by diverse causes [7]. Reciprocal interactions between mononuclear phagocytes and adaptive T and B lymphocyte subtypes play a decisive role in the control of macrophage activation. Further studies on monocytes from infected patients will establish how this virus manipulates innate and adaptive control mechanisms to facilitate its survival and spread [82,83].