Conjunctivitis as a presenting manifestation of coronavirus and the relationship between conjunctivitis and the development of serious pulmonary disease are important questions for ophthalmologists worldwide. Wu et al. [8] described in a series of 38 patients that patients with conjunctivitis were more likely to have higher white blood cell and neutrophil counts and higher levels of procalcitonin, C-reactive protein, and lactate dehydrogenase than patients without ocular symptoms, suggesting that ocular abnormalities occurred more frequently in patients with more severe COVID-19. However, this article did not compare the differences between women and men, and included critical patients, who were not included in our sample. We were unable to objectify any relationship between the presence of conjunctivitis and clinical, radiological, or laboratory severity in our sample of 301 cases. Furthermore, it is interesting to highlight that out of a hospitalized married couple who slept in the same room at home and had equal clinical severity, only the woman presented with conjunctivitis. This suggests that perhaps the appearance of conjunctivitis could depend on the host’s characteristics or the inoculation mechanism.