The article belong to COVID 19. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Jianing Wang and Ping Wang contributed equally to this article and should be considered co-first authors. Acknowledgements This study was supported by Grants from the National Natural Science Foundation of China (81971098). Funding This study was supported by Grants from the National Natural Science Foundation of China (81971098). Compliance with ethical standards Conflict of interest Jianing Wang, Ping Wang, Chunyi Li, Yihuan Huang, Chunxiao Yang and Lei Zhang declare no conflicts of interest. Statement of human and animal rights This article does not contain any studies with human participants or animals performed by any of the authors. Informed consent For this type of study, no informed consent is required.