Case # 1 2 3 4 5 6 7 8
Age (years) 15 13 12.6 9 6.7 11 12.6 14.8
Gender F M M M M M F M
Primary disease HSCT
PID (CTLA4 deficiency) HSCT
Myelodysplastic syndrome HSCT
B-ALL T-ALL Melanoma Liver Tx C-ANCA vasculitis.
Hemodialysis Kidney Tx
Immunosuppressive treatment/targeted therapy None (stopped for 1 month). CD4 cells: 216/ μL Ruxolitinib None (stopped for 2 months). CD4 cells: 30/ μL Oral mercaptopurine and methotrexate Trametinib Prednisone, tacrolimus Prednisone, azathioprine Prednisone, tacrolimus, mycophenolate (MMF)
Fever Yes No Yes Yes No Yes Yes No
Cough No No No Yes Yes Yes Yes Yes
Sore throat No Yes No No No No Yes No
Dyspnea Yes No No No No No No No
Lymphocytes/mm3
(minimum value) 730 1210 520 340 2730 970 380 1620
D-dimer ng/mL
(maximum value) 301 - 418 1143 370 - 1168 -
IL-6 pg/mL (maximum value) 9.60 2.30 - 192 - - - -
C- Reactive Protein (mg/L) 26.2 1.9 18.9 24.6 0.6 0.9 9 106
Ferritin (mg/dl) Not done Not done 622 1534 Not done Not done 1270 553
Chest X-ray Normal
(Previous
lobectomy) Interstitial infiltrate Interstitial infiltrate Interstitial infiltrate Focal infiltrate Mild parahilar infiltrates Normal initially but focal infiltrate on evolution Focal infiltrate
Required hospitalization Yes No No Yes No Yes Yes Yes
Treatment HCQ*
Remdesivir** IS withdrawal HCQ* IS withdrawal
HCQ*
Remdesivir**
Tocilizumab
Dexamethasone*** Trametinib withdrawal Reduction in IS (50% tacrolimus reduction) Reduction in IS (azathioprine withdrawal)
LPV/Rtv
HCQ* Reduction in IS (MMF withdrawal, tacrolimus decrease and prednisone increase)
HCQ*
Duration of stay (days) 11 - - 28 - 3 4 2
Complications O2 requirement on nasal cannula (maximun 2 lpm) None None HLH-like syndrome None None None None