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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 2539-2550 Body_part denotes solid organ http://purl.org/sig/ont/fma/fma55670
T2 2565-2588 Body_part denotes hematopoietic stem cell http://purl.org/sig/ont/fma/fma86475
T3 2584-2588 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T4 3522-3527 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T5 4080-4103 Body_part denotes hematopoietic stem cell http://purl.org/sig/ont/fma/fma86475
T6 4099-4103 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T7 4146-4151 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T8 4157-4163 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T9 4618-4623 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T10 5584-5589 Body_part denotes chest http://purl.org/sig/ont/fma/fma9576
T11 5597-5602 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T12 7173-7178 Body_part denotes Liver http://purl.org/sig/ont/fma/fma7197
T13 7214-7220 Body_part denotes Kidney http://purl.org/sig/ont/fma/fma7203
T14 7301-7306 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T15 7361-7366 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T16 7590-7596 Body_part denotes throat http://purl.org/sig/ont/fma/fma228738
T17 7656-7667 Body_part denotes Lymphocytes http://purl.org/sig/ont/fma/fma62863
T18 7844-7851 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T19 7963-7968 Body_part denotes Chest http://purl.org/sig/ont/fma/fma9576
T20 8728-8751 Body_part denotes hematopoietic stem cell http://purl.org/sig/ont/fma/fma86475
T21 8747-8751 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T22 8803-8807 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T23 8814-8827 Body_part denotes lymphoblastic http://purl.org/sig/ont/fma/fma83030
T24 8846-8850 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T25 8857-8870 Body_part denotes lymphoblastic http://purl.org/sig/ont/fma/fma83030
T26 11116-11121 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T27 12031-12049 Body_part denotes respiratory system http://purl.org/sig/ont/fma/fma7158
T28 12150-12155 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T29 12177-12181 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T30 12183-12209 Body_part denotes small intestine epithelium http://purl.org/sig/ont/fma/fma62017
T31 12183-12198 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T32 12199-12209 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T33 12235-12246 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T34 12325-12329 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T35 12637-12654 Body_part denotes regulatory T cell http://purl.org/sig/ont/fma/fma84070
T36 12650-12654 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T37 12693-12702 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T38 12726-12738 Body_part denotes interleukins http://purl.org/sig/ont/fma/fma86578
T39 12739-12743 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T40 12757-12768 Body_part denotes granulocyte http://purl.org/sig/ont/fma/fma62854
T41 12796-12806 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T42 12820-12827 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T43 12869-12876 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T44 14301-14306 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T45 14638-14645 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T46 14649-14662 Body_part denotes Interleukin-6 http://purl.org/sig/ont/fma/fma264829
T47 14649-14660 Body_part denotes Interleukin http://purl.org/sig/ont/fma/fma86578

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 2545-2550 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T2 3522-3527 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T3 4146-4151 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T4 4157-4163 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T5 4618-4623 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T6 5584-5589 Body_part denotes chest http://purl.obolibrary.org/obo/UBERON_0001443
T7 5597-5602 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T8 7173-7178 Body_part denotes Liver http://purl.obolibrary.org/obo/UBERON_0002107
T9 7214-7220 Body_part denotes Kidney http://purl.obolibrary.org/obo/UBERON_0002113
T10 7590-7596 Body_part denotes throat http://purl.obolibrary.org/obo/UBERON_0000341
T11 7963-7968 Body_part denotes Chest http://purl.obolibrary.org/obo/UBERON_0001443
T12 12031-12049 Body_part denotes respiratory system http://purl.obolibrary.org/obo/UBERON_0001004
T13 12177-12181 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T14 12183-12198 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T15 12189-12198 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T16 12199-12209 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T17 12235-12246 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T18 12325-12329 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T19 14301-14306 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 20-28 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 31-40 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T3 132-140 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 143-156 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T5 307-315 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 401-409 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 974-982 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 1192-1200 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 1203-1212 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T10 1299-1307 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 1370-1378 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T12 1381-1390 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T13 1768-1776 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 1846-1861 Disease denotes agranulocytosis http://purl.obolibrary.org/obo/MONDO_0001609
T15 1869-1883 Disease denotes acute leukemia http://purl.obolibrary.org/obo/MONDO_0010643
T16 1875-1883 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T17 1972-1981 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T18 2134-2142 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 2665-2671 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T20 2762-2778 Disease denotes pediatric cancer http://purl.obolibrary.org/obo/MONDO_0006517
T21 2772-2778 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T22 2907-2915 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T23 2918-2927 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T24 3146-3154 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T25 3266-3274 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T26 3649-3657 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T27 3789-3797 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 4236-4246 Disease denotes vasculitis http://purl.obolibrary.org/obo/MONDO_0018882
T29 4714-4722 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T30 4741-4748 Disease denotes anosmia http://purl.obolibrary.org/obo/MONDO_0010528
T31 4785-4819 Disease denotes hemophagocytic lymphohistiocytosis http://purl.obolibrary.org/obo/MONDO_0015540
T32 5006-5009 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T33 5123-5133 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550
T34 5480-5488 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 5571-5580 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T36 5634-5645 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T37 6069-6080 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T38 6463-6474 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T39 6564-6572 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T40 6773-6781 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T41 6968-6976 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T42 7094-7097 Disease denotes PID http://purl.obolibrary.org/obo/MONDO_0000922
T43 7122-7146 Disease denotes Myelodysplastic syndrome http://purl.obolibrary.org/obo/MONDO_0018881|http://purl.obolibrary.org/obo/MONDO_0044873
T45 7152-7157 Disease denotes B-ALL http://purl.obolibrary.org/obo/MONDO_0020511
T46 7158-7163 Disease denotes T-ALL http://purl.obolibrary.org/obo/MONDO_0004963|http://purl.obolibrary.org/obo/MONDO_0020512
T48 7164-7172 Disease denotes Melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T49 7189-7199 Disease denotes vasculitis http://purl.obolibrary.org/obo/MONDO_0018882
T50 7510-7513 Disease denotes MMF http://purl.obolibrary.org/obo/MONDO_0018942
T51 7585-7596 Disease denotes Sore throat http://purl.obolibrary.org/obo/MONDO_0002258
T52 8486-8489 Disease denotes MMF http://purl.obolibrary.org/obo/MONDO_0018942
T53 8666-8669 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T54 8764-8767 Disease denotes PID http://purl.obolibrary.org/obo/MONDO_0000922
T55 8776-8792 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T56 8794-8799 Disease denotes B-ALL http://purl.obolibrary.org/obo/MONDO_0020511
T57 8801-8836 Disease denotes B cell acute lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0004947|http://purl.obolibrary.org/obo/MONDO_0020511
T59 8808-8836 Disease denotes acute lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0004967
T60 8814-8836 Disease denotes lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0001018
T61 8828-8836 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T62 8838-8843 Disease denotes T-ALL http://purl.obolibrary.org/obo/MONDO_0004963|http://purl.obolibrary.org/obo/MONDO_0020512
T64 8844-8879 Disease denotes T cell acute lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0003540|http://purl.obolibrary.org/obo/MONDO_0004963
T66 8851-8879 Disease denotes acute lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0004967
T67 8857-8879 Disease denotes lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0001018
T68 8871-8879 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T69 8982-8985 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T70 8986-9020 Disease denotes hemophagocytic lymphohistiocytosis http://purl.obolibrary.org/obo/MONDO_0015540
T71 9022-9025 Disease denotes MMF http://purl.obolibrary.org/obo/MONDO_0018942
T72 9116-9124 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T73 9995-9998 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T74 10286-10294 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T75 11103-11129 Disease denotes inflammatory bowel disease http://purl.obolibrary.org/obo/MONDO_0005265
T76 11144-11152 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T77 11338-11344 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T78 11398-11414 Disease denotes childhood cancer http://purl.obolibrary.org/obo/MONDO_0006517
T79 11408-11414 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T80 11474-11490 Disease denotes childhood cancer http://purl.obolibrary.org/obo/MONDO_0006517
T81 11484-11490 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T82 11776-11784 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T83 11787-11796 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T84 11944-11952 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T85 12051-12059 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T86 12363-12378 Disease denotes viral pneumonia http://purl.obolibrary.org/obo/MONDO_0006012
T87 12369-12378 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T88 12411-12422 Disease denotes Lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T89 12833-12838 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T90 12908-12942 Disease denotes hemophagocytic lymphohistiocytosis http://purl.obolibrary.org/obo/MONDO_0015540
T91 13240-13251 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T92 13469-13479 Disease denotes Infectious http://purl.obolibrary.org/obo/MONDO_0005550
T93 13611-13614 Disease denotes HLH http://purl.obolibrary.org/obo/MONDO_0015540
T94 14197-14205 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T95 14596-14607 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 192-193 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T2 497-498 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 587-588 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 1332-1333 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 1432-1435 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T6 1793-1796 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T7 1815-1816 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 2052-2055 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T9 2112-2113 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 2419-2420 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 2545-2550 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T12 2579-2588 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cell
T13 2728-2731 http://purl.obolibrary.org/obo/CLO_0008190 denotes Per
T14 2801-2803 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T15 2825-2828 http://purl.obolibrary.org/obo/PR_000001343 denotes aim
T16 3002-3003 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T17 3375-3383 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test was
T18 3522-3527 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T19 3522-3527 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T20 3733-3734 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 3762-3768 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T22 3884-3885 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T23 4078-4079 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T24 4094-4103 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cell
T25 4144-4145 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 4146-4151 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T27 4146-4151 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T28 4155-4156 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T29 4157-4163 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T30 4157-4163 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T31 4157-4163 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T32 4198-4199 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 4234-4235 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T34 4415-4416 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T35 4618-4623 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T36 4783-4784 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T37 5584-5589 http://www.ebi.ac.uk/efo/EFO_0000965 denotes chest
T38 5597-5602 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T39 5597-5602 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T40 6514-6515 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41 6996-6999 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3 4
T42 7037-7039 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T43 7099-7104 http://purl.obolibrary.org/obo/PR_000001852 denotes CTLA4
T44 7152-7153 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T45 7173-7178 http://purl.obolibrary.org/obo/UBERON_0002107 denotes Liver
T46 7173-7178 http://www.ebi.ac.uk/efo/EFO_0000887 denotes Liver
T47 7214-7220 http://purl.obolibrary.org/obo/UBERON_0002113 denotes Kidney
T48 7214-7220 http://www.ebi.ac.uk/efo/EFO_0000927 denotes Kidney
T49 7214-7220 http://www.ebi.ac.uk/efo/EFO_0000929 denotes Kidney
T50 7297-7300 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T51 7301-7306 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T52 7357-7360 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T53 7361-7366 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T54 7714-7717 http://purl.obolibrary.org/obo/CLO_0001007 denotes 380
T55 7786-7788 http://purl.obolibrary.org/obo/CLO_0008426 denotes pg
T56 7963-7968 http://www.ebi.ac.uk/efo/EFO_0000965 denotes Chest
T57 8576-8578 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T58 8588-8591 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3 4
T59 8651-8654 http://purl.obolibrary.org/obo/UBERON_0003081 denotes lpm
T60 8706-8712 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T61 8716-8720 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T62 8716-8720 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T63 8742-8751 http://purl.obolibrary.org/obo/CL_0000034 denotes stem cell
T64 8794-8795 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T65 8801-8807 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T66 8844-8850 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T67 9074-9078 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3, 4
T68 9132-9133 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T69 9699-9700 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T70 9812-9813 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T71 10025-10026 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T72 10182-10183 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73 10382-10383 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T74 10472-10473 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75 10737-10738 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 10780-10783 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T77 10841-10842 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78 11003-11004 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T79 11166-11167 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T80 11375-11376 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T81 11396-11397 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T82 11520-11521 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 11660-11670 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T84 12015-12023 http://purl.obolibrary.org/obo/CLO_0009985 denotes focusing
T85 12031-12049 http://purl.obolibrary.org/obo/UBERON_0001004 denotes respiratory system
T86 12144-12155 http://purl.obolibrary.org/obo/CLO_0053065 denotes human cells
T87 12171-12176 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T88 12177-12181 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T89 12177-12181 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T90 12183-12198 http://purl.obolibrary.org/obo/UBERON_0002108 denotes small intestine
T91 12199-12209 http://purl.obolibrary.org/obo/UBERON_0000483 denotes epithelium
T92 12235-12246 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T93 12325-12329 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T94 12325-12329 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T95 12448-12449 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96 12509-12510 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T97 12599-12600 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T98 12637-12654 http://purl.obolibrary.org/obo/CL_0000815 denotes regulatory T cell
T99 12739-12743 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T100 12757-12794 http://purl.obolibrary.org/obo/PR_000005932 denotes granulocyte-colony-stimulating factor
T101 12901-12903 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T102 12906-12907 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T103 13765-13766 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T104 13877-13878 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T105 14024-14027 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T106 14301-14306 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T107 14301-14306 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T108 14307-14311 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T109 14649-14662 http://purl.obolibrary.org/obo/PR_000001393 denotes Interleukin-6
T110 14720-14721 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T111 14823-14826 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T112 15601-15604 http://purl.obolibrary.org/obo/CLO_0052676 denotes F-C

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 721-727 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T2 2087-2092 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T3 2124-2129 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T4 2371-2373 Chemical denotes La http://purl.obolibrary.org/obo/CHEBI_33336
T5 3196-3198 Chemical denotes La http://purl.obolibrary.org/obo/CHEBI_33336
T6 4682-4688 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T7 4905-4918 Chemical denotes triglycerides http://purl.obolibrary.org/obo/CHEBI_17855
T8 4980-4993 Chemical denotes dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T9 5806-5815 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T10 5847-5865 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T11 5913-5923 Chemical denotes remdesivir http://purl.obolibrary.org/obo/CHEBI_145994
T12 5996-6002 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T13 6149-6160 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T14 6198-6200 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T16 7094-7097 Chemical denotes PID http://purl.obolibrary.org/obo/CHEBI_8066
T17 7184-7188 Chemical denotes ANCA http://purl.obolibrary.org/obo/CHEBI_34507
T18 7380-7394 Chemical denotes mercaptopurine http://purl.obolibrary.org/obo/CHEBI_50667
T19 7399-7411 Chemical denotes methotrexate http://purl.obolibrary.org/obo/CHEBI_44185|http://purl.obolibrary.org/obo/CHEBI_50681
T21 7435-7445 Chemical denotes tacrolimus http://purl.obolibrary.org/obo/CHEBI_61049|http://purl.obolibrary.org/obo/CHEBI_61057
T23 7458-7470 Chemical denotes azathioprine http://purl.obolibrary.org/obo/CHEBI_2948
T24 7483-7493 Chemical denotes tacrolimus http://purl.obolibrary.org/obo/CHEBI_61049|http://purl.obolibrary.org/obo/CHEBI_61057
T26 7495-7508 Chemical denotes mycophenolate http://purl.obolibrary.org/obo/CHEBI_62932
T27 7510-7513 Chemical denotes MMF http://purl.obolibrary.org/obo/CHEBI_8764
T28 7781-7783 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T30 7844-7851 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T31 7892-7900 Chemical denotes Ferritin http://purl.obolibrary.org/obo/CHEBI_82594
T32 8332-8345 Chemical denotes Dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T33 8392-8402 Chemical denotes tacrolimus http://purl.obolibrary.org/obo/CHEBI_61049|http://purl.obolibrary.org/obo/CHEBI_61057
T35 8431-8443 Chemical denotes azathioprine http://purl.obolibrary.org/obo/CHEBI_2948
T36 8486-8489 Chemical denotes MMF http://purl.obolibrary.org/obo/CHEBI_8764
T37 8502-8512 Chemical denotes tacrolimus http://purl.obolibrary.org/obo/CHEBI_61049|http://purl.obolibrary.org/obo/CHEBI_61057
T39 8526-8536 Chemical denotes prednisone http://purl.obolibrary.org/obo/CHEBI_8382
T40 8608-8610 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T41 8716-8720 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T42 8764-8767 Chemical denotes PID http://purl.obolibrary.org/obo/CHEBI_8066
T43 8900-8918 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T44 8950-8969 Chemical denotes lopinavir/ritonavir http://purl.obolibrary.org/obo/CHEBI_145924
T45 8950-8959 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T46 8960-8969 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T47 8971-8973 Chemical denotes O2 http://purl.obolibrary.org/obo/CHEBI_15379
T48 8974-8980 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T49 9022-9025 Chemical denotes MMF http://purl.obolibrary.org/obo/CHEBI_8764
T50 9026-9039 Chemical denotes mycophenolate http://purl.obolibrary.org/obo/CHEBI_62932
T51 9960-9973 Chemical denotes Dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T52 10203-10217 Chemical denotes hydrocortisone http://purl.obolibrary.org/obo/CHEBI_17650
T53 10606-10612 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T54 10645-10654 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T55 11285-11302 Chemical denotes immunosuppressant http://purl.obolibrary.org/obo/CHEBI_35705
T56 12092-12103 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T57 12726-12738 Chemical denotes interleukins http://purl.obolibrary.org/obo/CHEBI_52998
T58 12739-12741 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T60 12745-12747 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T62 12751-12753 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T64 12820-12827 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T65 12869-12876 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T66 13586-13599 Chemical denotes dexamethasone http://purl.obolibrary.org/obo/CHEBI_41879
T67 13684-13692 Chemical denotes steroids http://purl.obolibrary.org/obo/CHEBI_35341
T68 14100-14109 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T69 14638-14645 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T70 14803-14812 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T71 14921-14930 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T72 14949-14954 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T73 14986-14990 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T74 15068-15090 Chemical denotes calcineurin inhibitors http://purl.obolibrary.org/obo/CHEBI_37153
T75 15068-15079 Chemical denotes calcineurin http://purl.obolibrary.org/obo/CHEBI_53439
T76 15080-15090 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T77 15464-15467 Chemical denotes P-M http://purl.obolibrary.org/obo/CHEBI_141444

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 12839-12847 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T2 12839-12847 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T3 12839-12847 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T4 12839-12847 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T5 15068-15079 http://purl.obolibrary.org/obo/GO_0004723 denotes calcineurin
T6 15068-15079 http://purl.obolibrary.org/obo/GO_0004722 denotes calcineurin

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 686-706 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T2 1101-1106 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T3 1141-1161 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T4 1846-1861 Phenotype denotes agranulocytosis http://purl.obolibrary.org/obo/HP_0012234
T5 1869-1883 Phenotype denotes acute leukemia http://purl.obolibrary.org/obo/HP_0002488
T6 2665-2671 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T7 2772-2778 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T8 4236-4246 Phenotype denotes vasculitis http://purl.obolibrary.org/obo/HP_0002633
T9 4503-4508 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T10 4714-4722 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T11 4741-4748 Phenotype denotes anosmia http://purl.obolibrary.org/obo/HP_0000458
T12 4752-4759 Phenotype denotes ageusia http://purl.obolibrary.org/obo/HP_0041051
T13 4858-4863 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T14 5571-5580 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T15 5634-5645 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T16 5649-5661 Phenotype denotes elevated CRP http://purl.obolibrary.org/obo/HP_0011227
T17 6069-6080 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T18 6179-6184 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T19 6463-6474 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T20 7122-7146 Phenotype denotes Myelodysplastic syndrome http://purl.obolibrary.org/obo/HP_0002863
T21 7164-7172 Phenotype denotes Melanoma http://purl.obolibrary.org/obo/HP_0002861
T22 7189-7199 Phenotype denotes vasculitis http://purl.obolibrary.org/obo/HP_0002633
T23 7515-7520 Phenotype denotes Fever http://purl.obolibrary.org/obo/HP_0001945
T24 7550-7555 Phenotype denotes Cough http://purl.obolibrary.org/obo/HP_0012735
T25 7585-7596 Phenotype denotes Sore throat http://purl.obolibrary.org/obo/HP_0033050
T26 7623-7630 Phenotype denotes Dyspnea http://purl.obolibrary.org/obo/HP_0002094
T27 8776-8792 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T28 8803-8839 Phenotype denotes cell acute lymphoblastic leukemia, T http://purl.obolibrary.org/obo/HP_0006727
T29 8844-8879 Phenotype denotes T cell acute lymphoblastic leukemia http://purl.obolibrary.org/obo/HP_0006727
T30 9314-9319 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T31 10571-10591 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T32 11103-11129 Phenotype denotes inflammatory bowel disease http://purl.obolibrary.org/obo/HP_0002037
T33 11338-11344 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T34 11408-11414 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T35 11484-11490 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T36 11587-11595 Phenotype denotes Oncology http://purl.obolibrary.org/obo/HP_0002664
T37 11695-11703 Phenotype denotes oncology http://purl.obolibrary.org/obo/HP_0002664
T38 12369-12378 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T39 12402-12409 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418
T40 12411-12422 Phenotype denotes Lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T41 12833-12838 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T42 13240-13251 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T43 13370-13386 Phenotype denotes elevated D-dimer http://purl.obolibrary.org/obo/HP_0033106
T44 14453-14458 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T45 14493-14513 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T46 14596-14607 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T47 14609-14625 Phenotype denotes elevated D-dimer http://purl.obolibrary.org/obo/HP_0033106

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-78 Sentence denotes Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain
T2 80-88 Sentence denotes Abstract
T3 89-191 Sentence denotes Limited information is available regarding SARS-CoV-2 infections in children with underlying diseases.
T4 192-350 Sentence denotes A retrospective study of children less than 15 years old with primary or secondary immunosuppression infected with SARS-CoV-2 during March 2020 was performed.
T5 351-518 Sentence denotes In this series, 8 immunocompromised patients with COVID-19 disease are reported, accounting for 15% of the positive cases detected in children in a reference hospital.
T6 519-736 Sentence denotes The severity of the symptoms was mild-moderate in the majority with a predominance of febrile syndrome, with mild radiological involvement and in some cases with mild respiratory distress that required oxygen therapy.
T7 737-892 Sentence denotes The rational and prudent management of these patients is discussed, evaluating possible treatments and options for hospitalization or outpatient follow-up.
T8 893-904 Sentence denotes Conclusion:
T9 905-1055 Sentence denotes In our experience, monitoring of children with immunosuppression and COVID-19 disease can be performed as outpatients if close monitoring is possible.
T10 1056-1174 Sentence denotes Hospitalization should be assessed when high fever, radiological involvement, and/or respiratory distress are present.
T11 1175-1189 Sentence denotes What is Known:
T12 1190-1241 Sentence denotes • SARS-CoV-2 infection is usually mild in children.
T13 1242-1254 Sentence denotes What is New:
T14 1255-1355 Sentence denotes • Outcome of immunosuppressed children with COVID-19 is generally good, with a mild-moderate course.
T15 1357-1369 Sentence denotes Introduction
T16 1370-1497 Sentence denotes SARS-CoV-2 infection in children younger than 10 years of age has been described in around 1% of identified cases in China [1].
T17 1498-1611 Sentence denotes Although data on children is still limited, most series agree that cases are mostly mild, even in infants [2, 3].
T18 1612-1767 Sentence denotes Very little information is available about pediatric patients with underlying diseases, and data in children with immunosuppression is almost non-existent.
T19 1768-1888 Sentence denotes COVID-19 serious disease has been described in a child with post-chemotherapy agranulocytosis due to acute leukemia [4].
T20 1889-2151 Sentence denotes Preliminary data from Bergamo [5] indicates that in Italy, practically no cases of infection have been detected in immunosuppressed patients (3 mild cases), which has led them to consider that this group of patients is not a high-risk group for COVID-19 disease.
T21 2152-2244 Sentence denotes Spain is currently one of the most affected countries with more than 100,000 reported cases.
T22 2245-2370 Sentence denotes The first case in Spain was declared on January 31st, 2020, and the first case in Madrid was declared on February 27th, 2020.
T23 2371-2517 Sentence denotes La Paz University Hospital in Madrid, Spain, is a national reference tertiary center for transplanted, oncological, and immunosuppressed children.
T24 2518-2727 Sentence denotes Over 1,300 pediatric solid organ (SOT) and 630 hematopoietic stem cell transplants (HSCT) have been performed in our hospital, and more than 3,200 cancer patients have been treated over more than five decades.
T25 2728-2820 Sentence denotes Per year, we diagnose 100–120 new pediatric cancer patients, and perform 35 HSCT and 65 SOT.
T26 2821-2979 Sentence denotes Our aim was to describe the children with primary or secondary immunosuppression, and SARS-CoV-2 infection attended in our hospital during the month of March.
T27 2981-3001 Sentence denotes Patients and methods
T28 3002-3233 Sentence denotes A retrospective study (1st to 31st of March, 2020) of children less than 15 years old with primary or secondary immunosuppression infected with SARS-CoV-2 and treated at the University Hospital La Paz, Madrid, Spain, was performed.
T29 3234-3328 Sentence denotes For inclusion in the study, the SARS-CoV-2 polymerase chain reaction (PCR) had to be positive.
T30 3329-3469 Sentence denotes PCR was performed via nasal swabs, and if the test was initially negative but clinical suspicion was high, it was repeated in the next 24 h.
T31 3470-3511 Sentence denotes Inpatients and outpatients were included.
T32 3512-3696 Sentence denotes Symptoms, blood analysis results and radiological data, previous underlying disease, immunosuppressive treatment, treatment received for COVID-19 disease, and evolution were collected.
T33 3698-3705 Sentence denotes Results
T34 3706-3827 Sentence denotes During the month of March, a total of 315 children were tested in our hospital for SARS-CoV-2 and 51 were positive (16%).
T35 3828-3883 Sentence denotes Twenty-eight of the positive cases (55%) were admitted.
T36 3884-3985 Sentence denotes A total of 8 positive cases (15%) were immunosuppressed patients, and 3 were followed as outpatients.
T37 3986-4285 Sentence denotes The underlying pathology was hemato-oncological in most cases (three patients had undergone a hematopoietic stem cell transplant), two patients had undergone a liver or a kidney transplant, and the last case was a girl on chronic hemodialysis with a vasculitis receiving immunosuppressive treatment.
T38 4286-4352 Sentence denotes The median age was 12.6 years (interquartile range: IQR 9.5–12.6).
T39 4353-4458 Sentence denotes All the patients had been on immunosuppressive treatment with a median duration of 24 months (IQR 12–93).
T40 4459-4596 Sentence denotes All had respiratory symptoms, 5 of them had fever, and the majority had slight radiological alterations (only two had focal infiltrates).
T41 4597-4662 Sentence denotes In only one case the chest X-ray worsened during hospitalization.
T42 4663-4723 Sentence denotes One patient needed oxygen therapy and one case had diarrhea.
T43 4724-4760 Sentence denotes None of them had anosmia or ageusia.
T44 4761-5024 Sentence denotes One patient developed a hemophagocytic lymphohistiocytosis-like syndrome (sHLH), with persistent fever, cytopenias, low fibrinogen and elevated triglycerides, and elevated ferritin, and required specific treatment with dexamethasone, as per the HLH-2004 protocol.
T45 5025-5413 Sentence denotes Antiviral treatment was initiated according to our National guidelines, developed by the National Infectious Disease Society (SEIP), in coordination with the National Pediatric Intensive Care Society (SECIP) and the National Pediatric Association (AEP) available at https://www.aeped.es/noticias/documento-manejo-clinico-paciente-pediatrico-y-pacientes-riesgo-con-infeccion-por-sars-cov2.
T46 5414-5680 Sentence denotes Hydroxychloroquine was initiated upon diagnosis (positive PCR for SARS-CoV-2) when there were signs/ symptoms of moderate-severe disease (respiratory signs, pneumonia on chest X ray, blood parameters of severity such as lymphopenia or elevated CRP, D-dimer or Il-6).
T47 5681-5757 Sentence denotes Remdesivir was requested, under compassionate use, in the most severe cases.
T48 5758-5890 Sentence denotes Following theses guidelines, in 5/8 cases, some antiviral treatment was prescribed, with hydroxychloroquine being the most frequent.
T49 5891-6203 Sentence denotes Two patients received remdesivir (the two oncological patients who required admission: patient 1 who had oxygen requirement and patient 4 who had persistent symptoms with severe lymphopenia and elevated inflammatory parameters) and only one patient received tocilizumab due to persistent fever and elevated IL-6.
T50 6204-6275 Sentence denotes There were no significant toxicities following the treatments received.
T51 6276-6423 Sentence denotes Immunosuppressive therapy was decreased or withdrawn in 6 patients (the other two had been off immunosuppression for 1 and 2 months, respectively).
T52 6424-6475 Sentence denotes All but one case developed progressive lymphopenia.
T53 6476-6508 Sentence denotes D-dimer was moderately elevated.
T54 6509-6657 Sentence denotes With a median follow up of 106 days (IQR 103–113) from COVID-19 diagnosis, no child required admission to the pediatric intensive care unit or died.
T55 6658-6782 Sentence denotes At present, all the patients are being followed up as outpatients and have had no further complications related to COVID-19.
T56 6783-6899 Sentence denotes The clinical characteristics of the patients, as well as details on the treatment received, are outlined in Table 1.
T57 6900-6984 Sentence denotes Table 1 Clinical characteristics of immunocompromised children with COVID-19 disease
T58 6985-7007 Sentence denotes Case # 1 2 3 4 5 6 7 8
T59 7008-7049 Sentence denotes Age (years) 15 13 12.6 9 6.7 11 12.6 14.8
T60 7050-7072 Sentence denotes Gender F M M M M M F M
T61 7073-7093 Sentence denotes Primary disease HSCT
T62 7094-7121 Sentence denotes PID (CTLA4 deficiency) HSCT
T63 7122-7151 Sentence denotes Myelodysplastic syndrome HSCT
T64 7152-7200 Sentence denotes B-ALL T-ALL Melanoma Liver Tx C-ANCA vasculitis.
T65 7201-7223 Sentence denotes Hemodialysis Kidney Tx
T66 7224-7296 Sentence denotes Immunosuppressive treatment/targeted therapy None (stopped for 1 month).
T67 7297-7307 Sentence denotes CD4 cells:
T68 7308-7356 Sentence denotes 216/ μL Ruxolitinib None (stopped for 2 months).
T69 7357-7367 Sentence denotes CD4 cells:
T70 7368-7514 Sentence denotes 30/ μL Oral mercaptopurine and methotrexate Trametinib Prednisone, tacrolimus Prednisone, azathioprine Prednisone, tacrolimus, mycophenolate (MMF)
T71 7515-7549 Sentence denotes Fever Yes No Yes Yes No Yes Yes No
T72 7550-7584 Sentence denotes Cough No No No Yes Yes Yes Yes Yes
T73 7585-7622 Sentence denotes Sore throat No Yes No No No No Yes No
T74 7623-7655 Sentence denotes Dyspnea Yes No No No No No No No
T75 7656-7671 Sentence denotes Lymphocytes/mm3
T76 7672-7722 Sentence denotes (minimum value) 730 1210 520 340 2730 970 380 1620
T77 7723-7736 Sentence denotes D-dimer ng/mL
T78 7737-7780 Sentence denotes (maximum value) 301 - 418 1143 370 - 1168 -
T79 7781-7831 Sentence denotes IL-6 pg/mL (maximum value) 9.60 2.30 - 192 - - - -
T80 7832-7891 Sentence denotes C- Reactive Protein (mg/L) 26.2 1.9 18.9 24.6 0.6 0.9 9 106
T81 7892-7962 Sentence denotes Ferritin (mg/dl) Not done Not done 622 1534 Not done Not done 1270 553
T82 7963-7981 Sentence denotes Chest X-ray Normal
T83 7982-7991 Sentence denotes (Previous
T84 7992-8186 Sentence denotes lobectomy) Interstitial infiltrate Interstitial infiltrate Interstitial infiltrate Focal infiltrate Mild parahilar infiltrates Normal initially but focal infiltrate on evolution Focal infiltrate
T85 8187-8240 Sentence denotes Required hospitalization Yes No No Yes No Yes Yes Yes
T86 8241-8255 Sentence denotes Treatment HCQ*
T87 8256-8301 Sentence denotes Remdesivir** IS withdrawal HCQ* IS withdrawal
T88 8302-8306 Sentence denotes HCQ*
T89 8307-8319 Sentence denotes Remdesivir**
T90 8320-8331 Sentence denotes Tocilizumab
T91 8332-8455 Sentence denotes Dexamethasone*** Trametinib withdrawal Reduction in IS (50% tacrolimus reduction) Reduction in IS (azathioprine withdrawal)
T92 8456-8463 Sentence denotes LPV/Rtv
T93 8464-8546 Sentence denotes HCQ* Reduction in IS (MMF withdrawal, tacrolimus decrease and prednisone increase)
T94 8547-8551 Sentence denotes HCQ*
T95 8552-8593 Sentence denotes Duration of stay (days) 11 - - 28 - 3 4 2
T96 8594-8703 Sentence denotes Complications O2 requirement on nasal cannula (maximun 2 lpm) None None HLH-like syndrome None None None None
T97 8704-8800 Sentence denotes F female, M male, HSCT: hematopoietic stem cell transplant, PID primary immunodeficiency, B-ALL:
T98 8801-9021 Sentence denotes B cell acute lymphoblastic leukemia, T-ALL T cell acute lymphoblastic leukemia, Tx transplant, HCQ hydroxychloroquine, IS immunosuppressors, LPV/Rtv lopinavir/ritonavir, O2 oxygen; HLH hemophagocytic lymphohistiocytosis.
T99 9022-9039 Sentence denotes MMF mycophenolate
T100 9040-9201 Sentence denotes *HCQ was initiated in patients 1, 3, 4, and 8 once confirmation of positive SARS-CoV-2 with a nasal swab was obtained (< 24 h from consultation at our hospital).
T101 9202-9299 Sentence denotes Patients 1, 3, and 8 attended the Emergency Department in the first 24 h after onset of symptoms.
T102 9300-9466 Sentence denotes Patient 4 had fever of 4 days when the nasal swab was obtained, and patient 7 received 5 days of LPV/Rtv initially and due to persistent symptoms was switched to HCQ.
T103 9467-9671 Sentence denotes According to our guidelines, the oral dose was as follows: HCQ 6.5 mg/kg/day (dosing q12 h) in 6 year-olds, and HCQ 10 mg/kg/day (dosing q12 h) in children > 6 years (maximum daily dose 400 mg) for 5 days
T104 9672-9956 Sentence denotes **Remdesivir was given for a total of 7 days on patient 1 and 10 days on patient 4, at an intravenous dose of 5 mg/kg on day 1, followed by a maintenance dose of 2.5 mg/kg from days 2 to 9 (patients <40 kg) or 200 mg/iv on day 1 followed by 100 mg/iv on days 2-9 (for patients >40 kg)
T105 9957-10044 Sentence denotes ***Dexamethasone was given as per the HLH 2004 trial, although with a shorter duration:
T106 10045-10217 Sentence denotes 10 mg/m2/day for 7 days, followed by 5 mg/m2/day for another 7 days, followed by 2.5 mg/m2 for 7 days and 1.25 mg/m2 for 2 days and then a tapering dose with hydrocortisone
T107 10219-10229 Sentence denotes Discussion
T108 10230-10403 Sentence denotes In this small series, 8 immunocompromised patients with COVID-19 disease are reported, accounting for 15% of the positive cases detected in children in a reference hospital.
T109 10404-10621 Sentence denotes The severity of the symptoms was mild-moderate in the majority with a predominance of febrile syndrome, with mild radiological involvement and in some cases with mild respiratory distress that required oxygen therapy.
T110 10622-10776 Sentence denotes Most patients received antiviral treatment, and immunosuppressive treatment was decreased or even discontinued for a short period of time in most of them.
T111 10777-10946 Sentence denotes It has been described by most of the authors that children have a milder disease than adults [2, 3] and immunocompromised patients do not seem to evolve differently [5].
T112 10947-10992 Sentence denotes Data in children is practically non-existent.
T113 10993-11195 Sentence denotes Recently, a study carried out by the European Society for Gastroenterology (ESPGHAN), described children with inflammatory bowel disease who presented COVID-19 disease with a mild outpatient course [6].
T114 11196-11327 Sentence denotes In addition, they warned of the risk of developing acute exacerbations of the disease if immunosuppressant treatments were delayed.
T115 11328-11374 Sentence denotes Data from cancer pediatric patients is scarce.
T116 11375-11538 Sentence denotes A recent report from a childhood cancer center in Lombardy, Italy, reported five positive cases in childhood cancer patients and all of them had a mild course [7].
T117 11539-11775 Sentence denotes In fact, the International Society of Pediatric Oncology (SIOP) highlighted that there is no reason to discontinue daily activities in pediatric hematology/oncology units; however, general principles for prevention were recommended [8].
T118 11776-11919 Sentence denotes SARS-CoV-2 infection is proposed to evolve in three phases, causing mortality in the third phase, after 2 or more weeks from symptom onset [9].
T119 11920-12050 Sentence denotes During the early phase, SARS-CoV-2 multiplies and establishes residence in the host, primarily focusing on the respiratory system.
T120 12051-12247 Sentence denotes SARS-CoV-2 binds to its target using the angiotensin-converting enzyme 2 (ACE2), receptor on human cells [10] mainly in human lung, small intestine epithelium, as well as the vascular endothelium.
T121 12248-12299 Sentence denotes This phase presents with mild respiratory symptoms.
T122 12300-12410 Sentence denotes During the second phase, lung involvement is established, with viral pneumonia and the development of hypoxia.
T123 12411-12508 Sentence denotes Lymphopenia appears or increases and a moderate increase in inflammatory markers can be observed.
T124 12509-12589 Sentence denotes A minority of patients will reach the third phase of systemic hyperinflammation.
T125 12590-12905 Sentence denotes There is a decrease in helper, suppressor, and regulatory T cell counts, with increase of inflammatory cytokines and biomarkers such as interleukins IL-2, IL-6, IL-7, granulocyte-colony-stimulating factor, macrophage inflammatory protein 1-α, tumor necrosis factor-α, C-reactive protein, ferritin, and D-dimer [11].
T126 12906-13020 Sentence denotes A hemophagocytic lymphohistiocytosis-like syndrome (sHLH) may occur in patients in this advanced stage of disease.
T127 13021-13207 Sentence denotes The possibility that immunosuppressed patients may not be able to progress to advanced stages of the disease could explain why most behave with mild symptoms, as previously reported [5].
T128 13208-13341 Sentence denotes Although our patients presented lymphopenia, most of them did not have significantly increased D-dimer or Il-6 when it was performed.
T129 13342-13528 Sentence denotes Despite two patients having elevated D-dimer, anticoagulation treatment was not given, as it is not recommended by our Spanish Infectious Disease Society based on the available evidence.
T130 13529-13648 Sentence denotes One of our patients developed sHLH that was treated with dexamethasone as per the HLH-2004 trial and entered remission.
T131 13649-13725 Sentence denotes The patient finished the course of steroids, and had no signs of recurrence.
T132 13726-13876 Sentence denotes Therefore, although most children have a mild-moderate course, it is important to be aware of possible complications that require prompt intervention.
T133 13877-14002 Sentence denotes A problem that must be assessed is the balance between risk and benefit of the suspension of the immunosuppressive treatment.
T134 14003-14121 Sentence denotes We believe that risk has to be individually assessed, as well as the necessity to start specific antiviral treatments.
T135 14122-14407 Sentence denotes Based on our experience, monitoring of children with immunosuppression and COVID-19 disease can be performed as outpatients, if close monitoring is possible with radiological and blood test controls if necessary, and carefully selecting the patients depending on their individual risk.
T136 14408-14525 Sentence denotes Hospitalization should be assessed when high fever, radiological involvement, and/or respiratory distress is present.
T137 14526-14664 Sentence denotes Also, it should be considered if there are signs of disease severity (lymphopenia, elevated D-dimer, C-reactive protein or Interleukin-6).
T138 14665-14719 Sentence denotes Depending on the evolution, an sHLH must be ruled out.
T139 14720-14842 Sentence denotes A judicious and conservative treatment seems safe and recommended since to date no antiviral treatment has shown efficacy.
T140 14843-15105 Sentence denotes It is particularly relevant to be very careful when recommending any specific antiviral treatment in this group of patients given the numerous drug interactions that may appear with their immunosuppressive treatment, such as calcineurin inhibitors, among others.
T141 15106-15186 Sentence denotes The available tables of pharmacological interactions should always be consulted.
T142 15187-15301 Sentence denotes Other groups should communicate their experience with these patients to offer appropriate treatment and follow-up.
T143 15303-15319 Sentence denotes Publisher’s note
T144 15320-15438 Sentence denotes Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
T145 15440-15459 Sentence denotes Author Contribution
T146 15460-15463 Sentence denotes Dr.
T147 15464-15475 Sentence denotes P-M and Dr.
T148 15476-15589 Sentence denotes M conceptualized and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript.
T149 15590-15593 Sentence denotes Dr.
T150 15594-15600 Sentence denotes F, Dr.
T151 15601-15609 Sentence denotes F-C, Dr.
T152 15610-15616 Sentence denotes R, Dr.
T153 15617-15722 Sentence denotes G collected data, collaborated in drafted the initial manuscript and reviewed and revised the manuscript.
T154 15723-15726 Sentence denotes Dr.
T155 15727-15879 Sentence denotes C designed the study, coordinated and supervised data collection, collaborated in drafted the initial manuscript and critically reviewed the manuscript.
T156 15880-15991 Sentence denotes All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
T157 15993-16026 Sentence denotes Compliance with ethical standards
T158 16028-16048 Sentence denotes Conflict of interest
T159 16049-16109 Sentence denotes The authors declare that they have no conflicts of interest.

MyTest

Id Subject Object Predicate Lexical cue
32860101-32600305-29215215 1608-1609 32600305 denotes 3
32860101-32600305-29215216 10874-10875 32600305 denotes 3

2_test

Id Subject Object Predicate Lexical cue
32860101-32600305-29215215 1608-1609 32600305 denotes 3
32860101-32600305-29215216 10874-10875 32600305 denotes 3

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T1 20-30 SP_7 denotes SARS-CoV-2
T2 44-60 CHEBI:35705;CHEBI:35705 denotes immunosuppressed
T3 132-142 SP_7 denotes SARS-CoV-2
T4 275-292 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T5 307-317 SP_7 denotes SARS-CoV-2
T6 401-409 SP_7 denotes COVID-19
T7 686-697 UBERON:0001004 denotes respiratory
T8 952-969 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T9 974-982 SP_7 denotes COVID-19
T10 1141-1152 UBERON:0001004 denotes respiratory
T11 1192-1202 SP_7 denotes SARS-CoV-2
T12 1268-1284 CHEBI:35705;CHEBI:35705 denotes immunosuppressed
T13 1299-1307 SP_7 denotes COVID-19
T16 1370-1380 SP_7 denotes SARS-CoV-2
T17 1726-1743 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T18 1768-1776 SP_7 denotes COVID-19
T19 2134-2142 SP_7 denotes COVID-19
T20 2545-2550 UBERON:0000062 denotes organ
T21 2565-2578 GO:0030097;CL:0000037 denotes hematopoietic
T22 2579-2588 CL:0000037 denotes stem cell
T23 2884-2901 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T24 2907-2917 SP_7 denotes SARS-CoV-2
T25 3114-3131 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T26 3146-3156 SP_7 denotes SARS-CoV-2
T27 3266-3276 SP_7 denotes SARS-CoV-2
T28 3351-3356 UBERON:0000004 denotes nasal
T29 3522-3527 UBERON:0000178 denotes blood
T30 3597-3614 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T31 3649-3657 SP_7 denotes COVID-19
T32 3789-3799 SP_7 denotes SARS-CoV-2
T33 4015-4021 GO:0030097 denotes hemato
T34 4080-4093 GO:0030097;CL:0000037 denotes hematopoietic
T35 4094-4103 CL:0000037 denotes stem cell
T36 4146-4151 UBERON:0002107 denotes liver
T37 4157-4163 UBERON:0002113 denotes kidney
T38 4257-4274 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T39 4382-4399 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T40 4467-4478 UBERON:0001004 denotes respiratory
T41 4618-4623 UBERON:0001443 denotes chest
T42 4785-4799 GO:0030097 denotes hemophagocytic
T43 4881-4891 GO:0005577 denotes fibrinogen
T44 4905-4918 CHEBI:17855;CHEBI:17855 denotes triglycerides
T45 4980-4993 CHEBI:41879;CHEBI:41879 denotes dexamethasone
T46 5403-5412 SP_7 denotes sars-cov2
T47 5414-5432 CHEBI:5801;DG_20;CHEBI:5801 denotes Hydroxychloroquine
T48 5480-5490 SP_7 denotes SARS-CoV-2
T49 5552-5563 UBERON:0001004 denotes respiratory
T50 5584-5589 UBERON:0001443 denotes chest
T51 5597-5602 UBERON:0000178 denotes blood
T52 5674-5678 PR:000001393 denotes Il-6
T53 5681-5691 DG_28 denotes Remdesivir
T54 5847-5865 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T55 5913-5923 DG_28 denotes remdesivir
T56 6149-6160 DG_35 denotes tocilizumab
T57 6198-6202 PR:000001393 denotes IL-6
T58 6371-6388 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T59 6564-6572 SP_7 denotes COVID-19
T60 6652-6656 GO:0016265 denotes died
T61 6773-6781 SP_7 denotes COVID-19
T91 6968-6976 SP_7 denotes COVID-19
T92 7099-7104 PR:000001852 denotes CTLA4
T93 7122-7137 CL:0000763 denotes Myelodysplastic
T94 509-520 CL:0000542 denotes hospital. T
T95 1109-1119 DG_28 denotes adiologica
T96 6-16 DG_28 denotes al outcome
T97 8320-8331 DG_35 denotes Tocilizumab
T98 8332-8345 CHEBI:41879;CHEBI:41879 denotes Dexamethasone
T99 8431-8443 CHEBI:2948;CHEBI:2948 denotes azathioprine
T100 8502-8512 CHEBI:15891;CHEBI:15891 denotes tacrolimus
T101 8526-8536 CHEBI:8382;CHEBI:8382 denotes prednisone
T102 8728-8741 GO:0030097;CL:0000037 denotes hematopoietic
T103 8742-8751 CL:0000037 denotes stem cell
T104 8801-8807 CL:0000236 denotes B cell
T105 8844-8850 CL:0000084 denotes T cell
T106 8900-8918 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T107 8923-8940 CHEBI:35705;CHEBI:35705 denotes immunosuppressors
T108 8950-8959 DG_23 denotes lopinavir
T109 8960-8969 DG_30 denotes ritonavir
T110 8971-8973 CHEBI:15379;CHEBI:15379 denotes O2
T111 8986-9000 GO:0030097 denotes hemophagocytic
T112 9026-9039 CHEBI:62932;CHEBI:62932 denotes mycophenolate
T113 9116-9126 SP_7 denotes SARS-CoV-2
T114 9134-9139 UBERON:0000004 denotes nasal
T115 9339-9344 UBERON:0001707 denotes nasal
T116 9345-9349 UBERON:0001823 denotes swab
T117 9500-9504 UBERON:0000165 denotes oral
T118 9674-9684 DG_28 denotes Remdesivir
T119 9960-9973 CHEBI:41879;CHEBI:41879 denotes Dexamethasone
T120 10203-10217 CHEBI:24751;CHEBI:24751 denotes hydrocortisone
T121 10286-10294 SP_7 denotes COVID-19
T122 10571-10582 UBERON:0001004 denotes respiratory
T123 10670-10687 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T124 10863-10869 UBERON:0007023 denotes adults
T125 11103-11121 UBERON:0000160 denotes inflammatory bowel
T126 11144-11152 SP_7 denotes COVID-19
T127 11285-11302 CHEBI:35705;CHEBI:35705 denotes immunosuppressant
T128 11776-11786 SP_7 denotes SARS-CoV-2
T129 11944-11954 SP_7 denotes SARS-CoV-2
T130 12031-12049 UBERON:0001004 denotes respiratory system
T131 12051-12061 SP_7 denotes SARS-CoV-2
T132 12092-12123 PG_10;PR:000003622 denotes angiotensin-converting enzyme 2
T133 12125-12129 G_3;PG_10;PR:000003622 denotes ACE2
T134 12144-12149 SP_6;NCBITaxon:9606 denotes human
T135 12171-12176 SP_6;NCBITaxon:9606 denotes human
T136 12177-12181 UBERON:0002048 denotes lung
T137 12183-12209 UBERON:0001902 denotes small intestine epithelium
T138 12235-12246 UBERON:0001986 denotes endothelium
T139 12278-12289 UBERON:0001004 denotes respiratory
T140 12325-12329 UBERON:0002048 denotes lung
T141 12363-12368 NCBITaxon:10239 denotes viral
T142 12637-12647 GO:0065007;CL:0000815 denotes regulatory
T143 12648-12654 CL:0000815 denotes T cell
T144 12739-12743 PR:000001379 denotes IL-2
T145 12747-12749 PR:000001393 denotes -6
T146 12751-12755 PR:000001317 denotes IL-7
T147 12757-12768 CL:0000094;PR:000005932 denotes granulocyte
T148 12768-12794 PR:000005932 denotes -colony-stimulating factor
T149 12796-12806 CL:0000235;PR:000002123 denotes macrophage
T150 12807-12831 PR:000002123 denotes inflammatory protein 1-α
T151 12833-12856 PR:000000134 denotes tumor necrosis factor-α
T152 12908-12922 GO:0030097 denotes hemophagocytic
T153 13314-13318 PR:000001393 denotes Il-6
T154 13388-13403 GO:0050817 denotes anticoagulation
T155 13586-13599 CHEBI:41879;CHEBI:41879 denotes dexamethasone
T156 13684-13692 CHEBI:35341;CHEBI:35341 denotes steroids
T157 13974-13991 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T158 14175-14192 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T159 14197-14205 SP_7 denotes COVID-19
T160 14301-14306 UBERON:0000178 denotes blood
T161 14493-14504 UBERON:0001004 denotes respiratory
T162 14627-14645 PR:000005897 denotes C-reactive protein
T163 14649-14662 PR:000001393 denotes Interleukin-6
T164 14986-14990 CHEBI:23888;CHEBI:23888 denotes drug
T165 15031-15048 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T166 15080-15090 CHEBI:35222;CHEBI:35222 denotes inhibitors
T167 15130-15145 CHEBI:52217;CHEBI:52217 denotes pharmacological
T73663 20-30 SP_7 denotes SARS-CoV-2
T94649 44-60 CHEBI:35705;CHEBI:35705 denotes immunosuppressed
T72535 132-142 SP_7 denotes SARS-CoV-2
T88064 275-292 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T14587 307-317 SP_7 denotes SARS-CoV-2
T36054 401-409 SP_7 denotes COVID-19
T52381 686-697 UBERON:0001004 denotes respiratory
T48927 952-969 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T25688 974-982 SP_7 denotes COVID-19
T36656 1141-1152 UBERON:0001004 denotes respiratory
T55804 1192-1202 SP_7 denotes SARS-CoV-2
T65556 1268-1284 CHEBI:35705;CHEBI:35705 denotes immunosuppressed
T9892 1299-1307 SP_7 denotes COVID-19
T14 11776-11786 SP_7 denotes SARS-CoV-2
T22728 14175-14192 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T46509 15031-15048 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T36004 1831-1839 SP_7 denotes t-chemot
T99054 1968-1978 SP_7 denotes of infect
T73137 2194-2200 GO:0030097 denotes d coun
T11476 2259-2272 GO:0030097;CL:0000037 denotes in Spain was
T67219 2273-2282 CL:0000037 denotes declared
T60255 2326-2331 UBERON:0002107 denotes Madr
T12929 2337-2343 UBERON:0002113 denotes decla
T76174 2438-2454 CHEBI:35705;CHEBI:35705 denotes e tertiary cente
T28832 2565-2581 CHEBI:35705;CHEBI:35705 denotes hematopoietic st
T91845 2650-2660 UBERON:0001004 denotes ore than 3
T12408 2800-2805 UBERON:0001443 denotes 35 H
T68453 2970-2985 GO:0030097 denotes of March. Pati
T35915 3069-3079 GO:0005577 denotes than 15 y
T70309 3093-3106 CHEBI:17855;CHEBI:17855 denotes primary or se
T77126 3169-3182 CHEBI:41879;CHEBI:41879 denotes at the Univer
T55342 3594-3604 SP_7 denotes e, immunos
T56862 3606-3624 CHEBI:5801;DG_20;CHEBI:5801 denotes pressive treatment
T46340 3672-3682 SP_7 denotes volution w
T92145 3745-3757 UBERON:0001004 denotes 15 children
T58391 3778-3784 UBERON:0001443 denotes spital
T36914 3792-3797 UBERON:0000178 denotes S-CoV
T41321 3869-3873 PR:000001393 denotes were
T12110 3876-3886 DG_28 denotes mitted. A
T46885 4043-4061 CHEBI:5801;DG_20;CHEBI:5801 denotes ases (three patien
T36685 4109-4119 DG_28 denotes plant), tw
T45851 4346-4357 DG_35 denotes 12.6). All
T82400 4396-4400 PR:000001393 denotes ive
T78751 4568-4584 CHEBI:35705;CHEBI:35705 denotes two had focal i
T22801 4761-4769 SP_7 denotes One pati
T64764 4847-4851 GO:0016265 denotes pers
T84702 4968-4976 SP_7 denotes atment w
T62 5156-5164 SP_7 denotes , in coo
T63 5257-5262 PR:000001852 denotes ic As
T64 5858-5862 PR:000001393 denotes roqu
T65 6047-6059 UBERON:0005169 denotes symptoms wi
T66 6283-6293 DG_28 denotes uppressive
T67 6329-6339 DG_28 denotes in 6 patie
T68 6411-6420 CHEBI:15891;CHEBI:15891 denotes spectivel
T69 6448-6460 CHEBI:2948;CHEBI:2948 denotes ed progressi
T70 6516-6525 CHEBI:15891;CHEBI:15891 denotes median fo
T71 6539-6549 CHEBI:8382;CHEBI:8382 denotes days (IQR
T72 6629-6634 UBERON:0000004 denotes inten
T73 6720-6733 GO:0030097;CL:0000037 denotes nts and have
T74 6734-6743 CL:0000037 denotes ad no fur
T75 6792-6798 CL:0000236 denotes cal ch
T76 6835-6841 CL:0000084 denotes l as d
T77 6893-6911 DG_20;CHEBI:5801;CHEBI:5801 denotes ble 1. Table 1 Cli
T78 6943-6951 DG_23 denotes ompromis
T79 6952-6963 DG_30 denotes d children
T80 6965-6967 CHEBI:15379;CHEBI:15379 denotes th
T81 6980-6994 GO:0030097 denotes ease Case # 1
T82 7020-7033 CHEBI:62932;CHEBI:62932 denotes 15 13 12.6 9
T83 7109-7119 SP_7 denotes ciency) HS
T84 7127-7132 UBERON:0000004 denotes dyspl
T85 7332-7337 UBERON:0001707 denotes (sto
T86 7338-7342 UBERON:0001823 denotes ped
T87 7495-7499 UBERON:0000165 denotes myco
T88 7664-7674 DG_28 denotes tes/mm3 (m
T89 7954-7967 CHEBI:41879;CHEBI:41879 denotes 1270 553 Ches
T90 8197-8212 CHEBI:35350;CHEBI:35350 denotes ospitalization
T95220 8278-8286 SP_7 denotes awal HCQ
T76668 8305-8310 PR:000001852 denotes * Rem
T83378 8328-8343 CL:0000763 denotes mab Dexamethaso
T95008 8396-8408 CL:0000542 denotes olimus reduc
T45414 8489-8499 DG_28 denotes withdrawa
T54245 8522-8532 DG_28 denotes and predni
T94900 8535-8546 DG_35 denotes e increase)
T76258 8547-8560 CHEBI:41879;CHEBI:41879 denotes HCQ* Duration
T95049 8581-8593 CHEBI:2948;CHEBI:2948 denotes - 28 - 3 4 2
T71044 8655-8664 CHEBI:15891;CHEBI:15891 denotes None Non
T41068 8678-8688 CHEBI:8382;CHEBI:8382 denotes drome None
T55685 8728-8741 GO:0030097;CL:0000037 denotes hematopoietic
T53406 8742-8751 CL:0000037 denotes stem cell
T50125 8801-8807 CL:0000236 denotes B cell
T74346 8844-8850 CL:0000084 denotes T cell
T78965 8900-8918 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T93758 8923-8940 CHEBI:35705;CHEBI:35705 denotes immunosuppressors
T25906 8950-8959 DG_23 denotes lopinavir
T85834 8960-8969 DG_30 denotes ritonavir
T87655 8971-8973 CHEBI:15379;CHEBI:15379 denotes O2
T74525 8986-9000 GO:0030097 denotes hemophagocytic
T46160 9026-9039 CHEBI:62932;CHEBI:62932 denotes mycophenolate
T4239 9116-9126 SP_7 denotes SARS-CoV-2
T71468 9134-9139 UBERON:0000004 denotes nasal
T51839 9339-9344 UBERON:0001707 denotes nasal
T14851 9345-9349 UBERON:0001823 denotes swab
T13016 9500-9504 UBERON:0000165 denotes oral
T62411 9674-9684 DG_28 denotes Remdesivir
T85530 9960-9973 CHEBI:41879;CHEBI:41879 denotes Dexamethasone
T80219 10203-10217 CHEBI:24751;CHEBI:24751 denotes hydrocortisone
T18376 10286-10294 SP_7 denotes COVID-19
T16128 10571-10582 UBERON:0001004 denotes respiratory
T46329 10670-10687 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T17443 10863-10869 UBERON:0007023 denotes adults
T37301 11103-11121 UBERON:0000160 denotes inflammatory bowel
T92613 11144-11152 SP_7 denotes COVID-19
T68218 11285-11302 CHEBI:35705;CHEBI:35705 denotes immunosuppressant
T99144 11776-11786 SP_7 denotes SARS-CoV-2
T9138 11944-11954 SP_7 denotes SARS-CoV-2
T32640 12031-12049 UBERON:0001004 denotes respiratory system
T43999 12051-12061 SP_7 denotes SARS-CoV-2
T92465 12092-12123 PG_10;PR:000003622 denotes angiotensin-converting enzyme 2
T71916 12125-12129 G_3;PG_10;PR:000003622 denotes ACE2
T76315 12144-12149 SP_6;NCBITaxon:9606 denotes human
T31203 12171-12176 SP_6;NCBITaxon:9606 denotes human
T74681 12177-12181 UBERON:0002048 denotes lung
T50061 12183-12209 UBERON:0001902 denotes small intestine epithelium
T30049 12235-12246 UBERON:0001986 denotes endothelium
T27899 12278-12289 UBERON:0001004 denotes respiratory
T94732 12325-12329 UBERON:0002048 denotes lung
T19924 12363-12368 NCBITaxon:10239 denotes viral
T51374 12637-12647 GO:0065007;CL:0000815 denotes regulatory
T18928 12648-12654 CL:0000815 denotes T cell
T17487 12739-12743 PR:000001379 denotes IL-2
T3917 12747-12749 PR:000001393 denotes -6
T29269 12751-12755 PR:000001317 denotes IL-7
T89744 12757-12768 CL:0000094;PR:000005932 denotes granulocyte
T69790 12768-12794 PR:000005932 denotes -colony-stimulating factor
T42852 12796-12806 CL:0000235;PR:000002123 denotes macrophage
T75791 12807-12831 PR:000002123 denotes inflammatory protein 1-α
T95062 12833-12856 PR:000000134 denotes tumor necrosis factor-α
T17748 12908-12922 GO:0030097 denotes hemophagocytic
T76398 13314-13318 PR:000001393 denotes Il-6
T42967 13388-13403 GO:0050817 denotes anticoagulation
T30209 13586-13599 CHEBI:41879;CHEBI:41879 denotes dexamethasone
T24327 13684-13692 CHEBI:35341;CHEBI:35341 denotes steroids
T20603 13974-13991 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T80687 14175-14192 CHEBI:35705;CHEBI:35705 denotes immunosuppression
T7555 14197-14205 SP_7 denotes COVID-19
T24066 14301-14306 UBERON:0000178 denotes blood
T98129 14493-14504 UBERON:0001004 denotes respiratory
T34959 14627-14645 PR:000005897 denotes C-reactive protein
T28648 14649-14662 PR:000001393 denotes Interleukin-6
T99212 14986-14990 CHEBI:23888;CHEBI:23888 denotes drug
T3749 15031-15048 CHEBI:35705;CHEBI:35705 denotes immunosuppressive
T58609 15080-15090 CHEBI:35222;CHEBI:35222 denotes inhibitors
T96758 15130-15145 CHEBI:52217;CHEBI:52217 denotes pharmacological

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 61-69 Species denotes children Tax:9606
3 20-40 Disease denotes SARS-CoV-2 infection MESH:C000657245
17 157-165 Species denotes children Tax:9606
18 217-225 Species denotes children Tax:9606
19 307-317 Species denotes SARS-CoV-2 Tax:2697049
20 387-395 Species denotes patients Tax:9606
21 485-493 Species denotes children Tax:9606
22 782-790 Species denotes patients Tax:9606
23 871-881 Species denotes outpatient Tax:9606
24 721-727 Chemical denotes oxygen MESH:D010100
25 132-153 Disease denotes SARS-CoV-2 infections MESH:C000657245
26 293-301 Disease denotes infected MESH:D007239
27 401-409 Disease denotes COVID-19 MESH:C000657245
28 605-621 Disease denotes febrile syndrome MESH:D000071072
29 686-706 Disease denotes respiratory distress MESH:D012128
32 1232-1240 Species denotes children Tax:9606
33 1197-1212 Disease denotes CoV-2 infection MESH:C000657245
36 1285-1293 Species denotes children Tax:9606
37 1299-1307 Disease denotes COVID-19 MESH:C000657245
42 938-946 Species denotes children Tax:9606
43 974-982 Disease denotes COVID-19 MESH:C000657245
44 1101-1106 Disease denotes fever MESH:D005334
45 1141-1161 Disease denotes respiratory distress MESH:D012128
60 1394-1402 Species denotes children Tax:9606
61 1515-1523 Species denotes children Tax:9606
62 1596-1603 Species denotes infants Tax:9606
63 1665-1673 Species denotes patients Tax:9606
64 1712-1720 Species denotes children Tax:9606
65 1817-1822 Species denotes child Tax:9606
66 2021-2029 Species denotes patients Tax:9606
67 2096-2104 Species denotes patients Tax:9606
68 1370-1390 Disease denotes SARS-CoV-2 infection MESH:C000657245
69 1768-1776 Disease denotes COVID-19 MESH:C000657245
70 1846-1861 Disease denotes agranulocytosis MESH:D000380
71 1869-1883 Disease denotes acute leukemia MESH:D015470
72 1972-1981 Disease denotes infection MESH:D007239
73 2134-2142 Disease denotes COVID-19 MESH:C000657245
81 2508-2516 Species denotes children Tax:9606
82 2672-2680 Species denotes patients Tax:9606
83 2779-2787 Species denotes patients Tax:9606
84 2849-2857 Species denotes children Tax:9606
85 2665-2671 Disease denotes cancer MESH:D009369
86 2772-2778 Disease denotes cancer MESH:D009369
87 2907-2927 Disease denotes SARS-CoV-2 infection MESH:C000657245
89 2981-2989 Species denotes Patients Tax:9606
94 3056-3064 Species denotes children Tax:9606
95 3146-3156 Species denotes SARS-CoV-2 Tax:2697049
96 3266-3276 Species denotes SARS-CoV-2 Tax:2697049
97 3132-3140 Disease denotes infected MESH:D007239
99 3649-3657 Disease denotes COVID-19 MESH:C000657245
132 7099-7104 Gene denotes CTLA4 Gene:1493
133 7297-7300 Gene denotes CD4 Gene:920
134 7357-7360 Gene denotes CD4 Gene:920
135 7781-7785 Gene denotes IL-6 Gene:3569
136 7832-7851 Gene denotes C- Reactive Protein Gene:1401
137 7316-7327 Chemical denotes Ruxolitinib MESH:C540383
138 7380-7394 Chemical denotes mercaptopurine MESH:D015122
139 7399-7411 Chemical denotes methotrexate MESH:D008727
140 7412-7422 Chemical denotes Trametinib MESH:C560077
141 7423-7433 Chemical denotes Prednisone MESH:D011241
142 7435-7445 Chemical denotes tacrolimus MESH:D016559
143 7446-7456 Chemical denotes Prednisone MESH:D011241
144 7458-7470 Chemical denotes azathioprine MESH:D001379
145 7471-7481 Chemical denotes Prednisone MESH:D011241
146 7483-7493 Chemical denotes tacrolimus MESH:D016559
147 7495-7508 Chemical denotes mycophenolate MESH:D009173
148 7510-7513 Chemical denotes MMF MESH:D009173
149 8251-8254 Chemical denotes HCQ MESH:D006886
150 8256-8266 Chemical denotes Remdesivir MESH:C000606551
151 8283-8286 Chemical denotes HCQ MESH:D006886
152 8291-8305 Chemical denotes withdrawal HCQ
153 8307-8317 Chemical denotes Remdesivir MESH:C000606551
154 8320-8345 Chemical denotes Tocilizumab Dexamethasone
155 8349-8359 Chemical denotes Trametinib MESH:C560077
156 8392-8402 Chemical denotes tacrolimus MESH:D016559
157 8431-8443 Chemical denotes azathioprine MESH:D001379
158 8502-8512 Chemical denotes tacrolimus MESH:D016559
159 8526-8536 Chemical denotes prednisone MESH:D011241
160 8608-8610 Chemical denotes O2 MESH:D010100
161 7515-7520 Disease denotes Fever MESH:D005334
162 7550-7555 Disease denotes Cough MESH:D003371
163 7623-7630 Disease denotes Dyspnea MESH:D004417
166 6954-6962 Species denotes children Tax:9606
167 6968-6976 Disease denotes COVID-19 MESH:C000657245
178 8896-8918 Chemical denotes HCQ hydroxychloroquine
179 8942-8949 Chemical denotes LPV/Rtv
180 8950-8969 Chemical denotes lopinavir/ritonavir MESH:C558899
181 8971-8980 Chemical denotes O2 oxygen MESH:D010100
182 9022-9025 Chemical denotes MMF MESH:D009173
183 9026-9039 Chemical denotes mycophenolate MESH:D009173
184 8764-8792 Disease denotes PID primary immunodeficiency MESH:D000081207
185 8814-8836 Disease denotes lymphoblastic leukemia MESH:D054198
186 8838-8879 Disease denotes T-ALL T cell acute lymphoblastic leukemia MESH:D054218
187 8982-9020 Disease denotes HLH hemophagocytic lymphohistiocytosis MESH:D051359
200 9062-9070 Species denotes patients Tax:9606
201 9116-9126 Species denotes SARS-CoV-2 Tax:2697049
202 9202-9210 Species denotes Patients Tax:9606
203 9300-9307 Species denotes Patient Tax:9606
204 9368-9375 Species denotes patient Tax:9606
205 9614-9622 Species denotes children Tax:9606
206 9041-9044 Chemical denotes HCQ MESH:D006886
207 9397-9404 Chemical denotes LPV/Rtv
208 9462-9465 Chemical denotes HCQ MESH:D006886
209 9526-9529 Chemical denotes HCQ MESH:D006886
210 9579-9582 Chemical denotes HCQ MESH:D006886
211 9314-9319 Disease denotes fever MESH:D005334
217 9720-9727 Species denotes patient Tax:9606
218 9745-9752 Species denotes patient Tax:9606
219 9862-9870 Species denotes patients Tax:9606
220 9940-9948 Species denotes patients Tax:9606
221 9674-9684 Chemical denotes Remdesivir MESH:C000606551
223 9960-9973 Chemical denotes Dexamethasone MESH:D003907
276 5658-5661 Gene denotes CRP Gene:1401
277 5674-5678 Gene denotes Il-6 Gene:3569
278 6198-6202 Gene denotes IL-6 Gene:3569
279 4881-4891 Gene denotes fibrinogen Gene:2244
280 3748-3756 Species denotes children Tax:9606
281 3789-3799 Species denotes SARS-CoV-2 Tax:2697049
282 3940-3948 Species denotes patients Tax:9606
283 4055-4063 Species denotes patients Tax:9606
284 4121-4129 Species denotes patients Tax:9606
285 4200-4204 Species denotes girl Tax:9606
286 4361-4369 Species denotes patients Tax:9606
287 4667-4674 Species denotes patient Tax:9606
288 4765-4772 Species denotes patient Tax:9606
289 5403-5412 Species denotes sars-cov2 Tax:2697049
290 5480-5490 Species denotes SARS-CoV-2 Tax:2697049
291 5895-5903 Species denotes patients Tax:9606
292 5945-5953 Species denotes patients Tax:9606
293 5978-5985 Species denotes patient Tax:9606
294 6019-6026 Species denotes patient Tax:9606
295 6132-6139 Species denotes patient Tax:9606
296 6334-6342 Species denotes patients Tax:9606
297 6587-6592 Species denotes child Tax:9606
298 6678-6686 Species denotes patients Tax:9606
299 6819-6827 Species denotes patients Tax:9606
300 4682-4688 Chemical denotes oxygen MESH:D010100
301 4905-4918 Chemical denotes triglycerides MESH:D014280
302 4980-4993 Chemical denotes dexamethasone MESH:D003907
303 5414-5432 Chemical denotes Hydroxychloroquine MESH:D006886
304 5681-5691 Chemical denotes Remdesivir MESH:C000606551
305 5847-5865 Chemical denotes hydroxychloroquine MESH:D006886
306 5913-5923 Chemical denotes remdesivir MESH:C000606551
307 5996-6002 Chemical denotes oxygen MESH:D010100
308 6149-6160 Chemical denotes tocilizumab MESH:C502936
309 4236-4246 Disease denotes vasculitis MESH:D014657
310 4467-4487 Disease denotes respiratory symptoms MESH:D012818
311 4503-4508 Disease denotes fever MESH:D005334
312 4714-4722 Disease denotes diarrhea MESH:D003967
313 4741-4748 Disease denotes anosmia MESH:D000857
314 4752-4759 Disease denotes ageusia MESH:D000370
315 4785-4833 Disease denotes hemophagocytic lymphohistiocytosis-like syndrome MESH:D051359
316 4858-4863 Disease denotes fever MESH:D005334
317 4865-4875 Disease denotes cytopenias MESH:D006402
318 5123-5141 Disease denotes Infectious Disease MESH:D003141
319 5571-5580 Disease denotes pneumonia MESH:D011014
320 5634-5645 Disease denotes lymphopenia MESH:D008231
321 6069-6080 Disease denotes lymphopenia MESH:D008231
322 6179-6184 Disease denotes fever MESH:D005334
323 6230-6240 Disease denotes toxicities MESH:D064420
324 6463-6474 Disease denotes lymphopenia MESH:D008231
325 6564-6572 Disease denotes COVID-19 MESH:C000657245
326 6652-6656 Disease denotes died MESH:D003643
327 6773-6781 Disease denotes COVID-19 MESH:C000657245
335 10272-10280 Species denotes patients Tax:9606
336 10370-10378 Species denotes children Tax:9606
337 10627-10635 Species denotes patients Tax:9606
338 10606-10612 Chemical denotes oxygen MESH:D010100
339 10286-10294 Disease denotes COVID-19 MESH:C000657245
340 10490-10506 Disease denotes febrile syndrome MESH:D000071072
341 10571-10591 Disease denotes respiratory distress MESH:D012128
354 10827-10835 Species denotes children Tax:9606
355 10899-10907 Species denotes patients Tax:9606
356 10955-10963 Species denotes children Tax:9606
357 11089-11097 Species denotes children Tax:9606
358 11173-11183 Species denotes outpatient Tax:9606
359 11355-11363 Species denotes patients Tax:9606
360 11491-11499 Species denotes patients Tax:9606
361 11103-11129 Disease denotes inflammatory bowel disease MESH:D015212
362 11144-11152 Disease denotes COVID-19 MESH:C000657245
363 11338-11344 Disease denotes cancer MESH:D009369
364 11408-11414 Disease denotes cancer MESH:D009369
365 11484-11490 Disease denotes cancer MESH:D009369
388 12092-12123 Gene denotes angiotensin-converting enzyme 2 Gene:59272
389 12125-12129 Gene denotes ACE2 Gene:59272
390 12739-12743 Gene denotes IL-2 Gene:3558
391 12745-12749 Gene denotes IL-6 Gene:3569
392 12751-12755 Gene denotes IL-7 Gene:3574
393 12757-12794 Gene denotes granulocyte-colony-stimulating factor Gene:1440
394 12796-12831 Gene denotes macrophage inflammatory protein 1-α Gene:1230
395 12833-12856 Gene denotes tumor necrosis factor-α Gene:7124
396 12858-12876 Gene denotes C-reactive protein Gene:1401
397 11944-11954 Species denotes SARS-CoV-2 Tax:2697049
398 12051-12061 Species denotes SARS-CoV-2 Tax:2697049
399 12144-12149 Species denotes human Tax:9606
400 12171-12176 Species denotes human Tax:9606
401 12523-12531 Species denotes patients Tax:9606
402 12977-12985 Species denotes patients Tax:9606
403 11776-11796 Disease denotes SARS-CoV-2 infection MESH:C000657245
404 11844-11853 Disease denotes mortality MESH:D003643
405 12278-12298 Disease denotes respiratory symptoms MESH:D012818
406 12363-12378 Disease denotes viral pneumonia
407 12402-12409 Disease denotes hypoxia MESH:D000860
408 12411-12422 Disease denotes Lymphopenia MESH:D008231
409 12908-12956 Disease denotes hemophagocytic lymphohistiocytosis-like syndrome MESH:D051359
421 13314-13318 Gene denotes Il-6 Gene:3569
422 13059-13067 Species denotes patients Tax:9606
423 13221-13229 Species denotes patients Tax:9606
424 13354-13362 Species denotes patients Tax:9606
425 13540-13548 Species denotes patients Tax:9606
426 13653-13660 Species denotes patient Tax:9606
427 13751-13759 Species denotes children Tax:9606
428 13586-13599 Chemical denotes dexamethasone MESH:D003907
429 13684-13692 Chemical denotes steroids MESH:D013256
430 13240-13251 Disease denotes lymphopenia MESH:D008231
431 13469-13487 Disease denotes Infectious Disease MESH:D003141
441 14627-14645 Gene denotes C-reactive protein Gene:1401
442 14649-14662 Gene denotes Interleukin-6 Gene:3569
443 14161-14169 Species denotes children Tax:9606
444 14363-14371 Species denotes patients Tax:9606
445 14958-14966 Species denotes patients Tax:9606
446 14197-14205 Disease denotes COVID-19 MESH:C000657245
447 14453-14458 Disease denotes fever MESH:D005334
448 14493-14513 Disease denotes respiratory distress MESH:D012128
449 14596-14607 Disease denotes lymphopenia MESH:D008231
451 15247-15255 Species denotes patients Tax:9606