Supplemental Information Document S1. Figures S1–S7 Document S2. Tables S1–S16 Document S2. Article plus Supplemental Information Acknowledgments The authors would like to thank Protein Metrics for providing licenses for their software used here and the developers of pGlyco for productive discussions regarding their software. We would also like to thank Galit Alter of the Ragon Institute for facilitating this collaborative effort. This effort was facilitated by the ThermoFisher Scientific appointed Center of Excellence in Glycoproteomics at the Complex Carbohydrate Research Center at the University of Georgia (co-directed by M.T. and L.W.). This research is supported in part by the National Institutes of Health R35GM119850 (N.E.L.), NNF10CC1016517 (N.E.L.), R01AI139238 (M.A.B.), R01AI147884-01A1S1 (B.C.); Massachusetts Consortium on Pathogen Readiness (B.C.); and National Institutes of Health U01CA207824 (R.J.W.), P41GM103390 (R.J.W.), P41GM103490 (M.T. and L.W.), U01GM125267 (M.T.), and R01GM130915 (L.W.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Author Contributions Conceptualization, M.T., B.C., R.J.W., and L.W.; Methodology, Software, Validation, Formal Analysis, Investigation, Resources, and Data Curation, P.Z., J.L.P., O.C.G., Y.C., T.X., K.E.R., K.A., B.P.K., R.B., D.H.B., M.A.B., N.E.L., M.T., B.C., R.J.W., and L.W.; Writing—Original Draft, P.Z., J.L.P., and L.W.; Writing—Review & Editing, all authors; Visualization, P.Z., J.L.P., O.C.G., Y.C., M.T., B.C., R.J.W., and L.W.; Supervision, Project Administration, and Funding Acquisition, D.H.B., M.A.B., N.E.L., M.T., B.C., R.J.W., and L.W. Declaration of Interests The authors declare no competing interests. Supplemental Information can be found online at https://doi.org/10.1016/j.chom.2020.08.004.