PMC:7279721
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T1 | 152-160 | Body_part | denotes | troponin | http://purl.org/sig/ont/fma/fma62338 |
T2 | 583-593 | Body_part | denotes | troponin-I | http://purl.org/sig/ont/fma/fma62340 |
T3 | 876-891 | Body_part | denotes | coronary artery | http://purl.org/sig/ont/fma/fma49893 |
T4 | 926-931 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
T5 | 984-992 | Body_part | denotes | troponin | http://purl.org/sig/ont/fma/fma62338 |
T6 | 1145-1153 | Body_part | denotes | troponin | http://purl.org/sig/ont/fma/fma62338 |
T7 | 1284-1294 | Body_part | denotes | troponin I | http://purl.org/sig/ont/fma/fma62340 |
T8 | 1284-1292 | Body_part | denotes | troponin | http://purl.org/sig/ont/fma/fma62338 |
T9 | 1441-1451 | Body_part | denotes | troponin I | http://purl.org/sig/ont/fma/fma62340 |
T10 | 1441-1449 | Body_part | denotes | troponin | http://purl.org/sig/ont/fma/fma62338 |
T11 | 1665-1673 | Body_part | denotes | troponin | http://purl.org/sig/ont/fma/fma62338 |
T12 | 1814-1822 | Body_part | denotes | Troponin | http://purl.org/sig/ont/fma/fma62338 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 876-891 | Body_part | denotes | coronary artery | http://purl.obolibrary.org/obo/UBERON_0001621 |
T2 | 885-891 | Body_part | denotes | artery | http://purl.obolibrary.org/obo/UBERON_0001637 |
T3 | 926-931 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
4 | 46-54 | Species | denotes | Patients | Tax:9606 |
5 | 25-42 | Disease | denotes | Myocardial Injury | MESH:D009202 |
6 | 73-81 | Disease | denotes | COVID-19 | MESH:C000657245 |
7 | 82-91 | Disease | denotes | Infection | MESH:D007239 |
12 | 218-226 | Species | denotes | patients | Tax:9606 |
13 | 117-134 | Disease | denotes | myocardial injury | MESH:D009202 |
14 | 232-256 | Disease | denotes | Coronavirus Disease 2019 | MESH:C000657245 |
15 | 258-266 | Disease | denotes | COVID-19 | MESH:C000657245 |
18 | 318-335 | Disease | denotes | myocardial injury | MESH:D009202 |
19 | 417-425 | Disease | denotes | COVID-19 | MESH:C000657245 |
22 | 435-443 | Species | denotes | Patients | Tax:9606 |
23 | 449-457 | Disease | denotes | COVID-19 | MESH:C000657245 |
37 | 832-835 | Species | denotes | men | Tax:9606 |
38 | 963-971 | Species | denotes | patients | Tax:9606 |
39 | 1067-1075 | Species | denotes | patients | Tax:9606 |
40 | 1123-1131 | Species | denotes | patients | Tax:9606 |
41 | 837-859 | Disease | denotes | Cardiovascular disease | MESH:D002318 |
42 | 861-864 | Disease | denotes | CVD | MESH:D002318 |
43 | 876-899 | Disease | denotes | coronary artery disease | MESH:D003324 |
44 | 901-920 | Disease | denotes | atrial fibrillation | MESH:D001281 |
45 | 926-939 | Disease | denotes | heart failure | MESH:D006333 |
46 | 1017-1029 | Disease | denotes | hypertension | MESH:D006973 |
47 | 1034-1042 | Disease | denotes | diabetes | MESH:D003920 |
48 | 1260-1277 | Disease | denotes | myocardial injury | MESH:D009202 |
49 | 1360-1365 | Disease | denotes | death | MESH:D003643 |
61 | 1621-1629 | Species | denotes | patients | Tax:9606 |
62 | 1727-1735 | Species | denotes | Patients | Tax:9606 |
63 | 1792-1800 | Species | denotes | patients | Tax:9606 |
64 | 1839-1847 | Species | denotes | patients | Tax:9606 |
65 | 1584-1601 | Disease | denotes | Myocardial injury | MESH:D009202 |
66 | 1648-1656 | Disease | denotes | COVID-19 | MESH:C000657245 |
67 | 1741-1744 | Disease | denotes | CVD | MESH:D002318 |
68 | 1769-1786 | Disease | denotes | myocardial injury | MESH:D009202 |
69 | 1809-1812 | Disease | denotes | CVD | MESH:D002318 |
70 | 1866-1874 | Disease | denotes | COVID-19 | MESH:C000657245 |
71 | 1909-1918 | Disease | denotes | mortality | MESH:D003643 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 36-42 | Disease | denotes | Injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T2 | 73-81 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T3 | 82-91 | Disease | denotes | Infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T4 | 128-134 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T5 | 232-256 | Disease | denotes | Coronavirus Disease 2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T6 | 258-266 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T7 | 329-335 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T8 | 417-425 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T9 | 449-457 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T10 | 837-865 | Disease | denotes | Cardiovascular disease (CVD) | http://purl.obolibrary.org/obo/MONDO_0004995 |
T11 | 876-899 | Disease | denotes | coronary artery disease | http://purl.obolibrary.org/obo/MONDO_0005010 |
T12 | 885-899 | Disease | denotes | artery disease | http://purl.obolibrary.org/obo/MONDO_0000473 |
T13 | 901-920 | Disease | denotes | atrial fibrillation | http://purl.obolibrary.org/obo/MONDO_0004981 |
T14 | 926-939 | Disease | denotes | heart failure | http://purl.obolibrary.org/obo/MONDO_0005252 |
T15 | 1017-1029 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
T16 | 1034-1042 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
T17 | 1271-1277 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T18 | 1595-1601 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T19 | 1648-1656 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T20 | 1780-1786 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T21 | 1866-1874 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 281-291 | http://purl.obolibrary.org/obo/BFO_0000030 | denotes | Objectives |
T2 | 363-364 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T3 | 885-891 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | artery |
T4 | 885-891 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | artery |
T5 | 926-931 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
T6 | 926-931 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
T7 | 926-931 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
T8 | 926-931 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
T9 | 1044-1045 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T10 | 1055-1058 | http://purl.obolibrary.org/obo/CLO_0001404 | denotes | 506 |
T11 | 1118-1120 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 36 |
T12 | 1313-1316 | http://purl.obolibrary.org/obo/CLO_0001375 | denotes | 455 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-91 | Sentence | denotes | Prevalence and Impact of Myocardial Injury in Patients Hospitalized with COVID-19 Infection |
T2 | 92-102 | Sentence | denotes | Background |
T3 | 103-280 | Sentence | denotes | The degree of myocardial injury, as reflected by troponin elevation, and associated outcomes among US hospitalized patients with Coronavirus Disease 2019 (COVID-19) are unknown. |
T4 | 281-291 | Sentence | denotes | Objectives |
T5 | 292-426 | Sentence | denotes | To describe the degree of myocardial injury and associated outcomes in a large hospitalized cohort with laboratory-confirmed COVID-19. |
T6 | 427-434 | Sentence | denotes | Methods |
T7 | 435-682 | Sentence | denotes | Patients with COVID-19 admitted to one of five Mount Sinai Health System hospitals in New York City between February 27th and April 12th, 2020 with troponin-I (normal value <0.03ng/mL) measured within 24 hours of admission were included (n=2,736). |
T8 | 683-781 | Sentence | denotes | Demographics, medical history, admission labs, and outcomes were captured from the hospitals’ EHR. |
T9 | 782-789 | Sentence | denotes | Results |
T10 | 790-836 | Sentence | denotes | The median age was 66.4 years, with 59.6% men. |
T11 | 837-1043 | Sentence | denotes | Cardiovascular disease (CVD) including coronary artery disease, atrial fibrillation, and heart failure, was more prevalent in patients with higher troponin concentrations, as were hypertension and diabetes. |
T12 | 1044-1104 | Sentence | denotes | A total of 506 (18.5%) patients died during hospitalization. |
T13 | 1105-1169 | Sentence | denotes | In all, 985 (36%) patients had elevated troponin concentrations. |
T14 | 1170-1379 | Sentence | denotes | After adjusting for disease severity and relevant clinical factors, even small amounts of myocardial injury (e.g. troponin I 0.03-0.09ng/mL, n=455, 16.6%) were significantly associated with death (adjusted HR: |
T15 | 1380-1571 | Sentence | denotes | 1.75, 95% CI 1.37-2.24; P<0.001) while greater amounts (e.g. troponin I>0.09 ng/dL, n=530, 19.4%) were significantly associated with higher risk (adjusted HR 3.03, 95% CI 2.42-3.80; P<0.001). |
T16 | 1572-1583 | Sentence | denotes | Conclusions |
T17 | 1584-1726 | Sentence | denotes | Myocardial injury is prevalent among patients hospitalized with COVID-19 however troponin concentrations were generally present at low levels. |
T18 | 1727-1813 | Sentence | denotes | Patients with CVD are more likely to have myocardial injury than patients without CVD. |
T19 | 1814-1919 | Sentence | denotes | Troponin elevation among patients hospitalized with COVID-19 is associated with higher risk of mortality. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 837-859 | Phenotype | denotes | Cardiovascular disease | http://purl.obolibrary.org/obo/HP_0001626 |
T2 | 901-920 | Phenotype | denotes | atrial fibrillation | http://purl.obolibrary.org/obo/HP_0005110 |
T3 | 926-939 | Phenotype | denotes | heart failure | http://purl.obolibrary.org/obo/HP_0001635 |
T4 | 1017-1029 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |