PMC:7276828
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
3 | 10-14 | Gene | denotes | ACE2 | Gene:59272 |
4 | 62-70 | Species | denotes | Patients | Tax:9606 |
5 | 57-61 | Disease | denotes | COPD | MESH:D029424 |
14 | 294-325 | Gene | denotes | angiotensin converting enzyme 2 | Gene:59272 |
15 | 327-331 | Gene | denotes | ACE2 | Gene:59272 |
16 | 192-200 | Species | denotes | patients | Tax:9606 |
17 | 274-284 | Species | denotes | SARS‐CoV‐2 | Tax:2697049 |
18 | 120-129 | Disease | denotes | Mortality | MESH:D003643 |
19 | 135-159 | Disease | denotes | coronavirus disease 2019 | MESH:C000657245 |
20 | 161-169 | Disease | denotes | COVID‐19 | MESH:C000657245 |
21 | 187-191 | Disease | denotes | COPD | MESH:D029424 |
25 | 395-399 | Gene | denotes | ACE2 | Gene:59272 |
26 | 453-461 | Species | denotes | patients | Tax:9606 |
27 | 448-452 | Disease | denotes | COPD | MESH:D029424 |
31 | 561-565 | Gene | denotes | ACE2 | Gene:59272 |
32 | 585-593 | Species | denotes | patients | Tax:9606 |
33 | 580-584 | Disease | denotes | COPD | MESH:D029424 |
39 | 718-722 | Gene | denotes | ACE2 | Gene:59272 |
40 | 806-814 | Species | denotes | patients | Tax:9606 |
41 | 754-774 | Disease | denotes | SARS‐CoV‐2 infection | MESH:C000657245 |
42 | 801-805 | Disease | denotes | COPD | MESH:D029424 |
43 | 878-886 | Disease | denotes | COVID‐19 | MESH:C000657245 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T1 | 33-53 | Body_part | denotes | Bronchial Epithelium | http://purl.org/sig/ont/fma/fma67782 |
T2 | 43-53 | Body_part | denotes | Epithelium | http://purl.org/sig/ont/fma/fma9639 |
T3 | 222-226 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
T4 | 514-517 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
T5 | 782-799 | Body_part | denotes | respiratory tract | http://purl.org/sig/ont/fma/fma265130 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 33-53 | Body_part | denotes | Bronchial Epithelium | http://purl.obolibrary.org/obo/UBERON_0002031 |
T2 | 43-53 | Body_part | denotes | Epithelium | http://purl.obolibrary.org/obo/UBERON_0000483 |
T3 | 782-799 | Body_part | denotes | respiratory tract | http://purl.obolibrary.org/obo/UBERON_0000065 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 57-61 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
T2 | 135-159 | Disease | denotes | coronavirus disease 2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T3 | 161-169 | Disease | denotes | COVID‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T4 | 187-191 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
T5 | 274-278 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T6 | 448-452 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
T7 | 580-584 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
T8 | 754-758 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T9 | 765-799 | Disease | denotes | infection of the respiratory tract | http://purl.obolibrary.org/obo/MONDO_0024355 |
T10 | 765-774 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T11 | 801-805 | Disease | denotes | COPD | http://purl.obolibrary.org/obo/MONDO_0005002 |
T12 | 878-886 | Disease | denotes | COVID‐19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 43-53 | http://purl.obolibrary.org/obo/UBERON_0000483 | denotes | Epithelium |
T2 | 110-119 | http://purl.obolibrary.org/obo/BFO_0000030 | denotes | Objective |
T3 | 410-420 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T1 | 294-305 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 57-61 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
T2 | 79-89 | Phenotype | denotes | Overweight | http://purl.obolibrary.org/obo/HP_0025502 |
T3 | 187-191 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
T4 | 448-452 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
T5 | 470-480 | Phenotype | denotes | overweight | http://purl.obolibrary.org/obo/HP_0025502 |
T6 | 580-584 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
T7 | 602-612 | Phenotype | denotes | overweight | http://purl.obolibrary.org/obo/HP_0025502 |
T8 | 801-805 | Phenotype | denotes | COPD | http://purl.obolibrary.org/obo/HP_0006510 |
T9 | 823-833 | Phenotype | denotes | overweight | http://purl.obolibrary.org/obo/HP_0025502 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-89 | Sentence | denotes | Increased ACE2 Expression in the Bronchial Epithelium of COPD Patients who are Overweight |
T2 | 91-99 | Sentence | denotes | Abstract |
T3 | 100-108 | Sentence | denotes | Abstract |
T4 | 110-119 | Sentence | denotes | Objective |
T5 | 120-201 | Sentence | denotes | Mortality from coronavirus disease 2019 (COVID‐19) is increased in COPD patients. |
T6 | 202-273 | Sentence | denotes | Furthermore, higher body mass index (BMI) is related to severe disease. |
T7 | 274-356 | Sentence | denotes | SARS‐CoV‐2 utilises angiotensin converting enzyme 2 (ACE2) to gain cellular entry. |
T8 | 358-365 | Sentence | denotes | Methods |
T9 | 366-529 | Sentence | denotes | We have investigated whether ACE2 bronchial epithelial expression is increased in COPD patients who are overweight compared to those who are not by RNA sequencing. |
T10 | 531-538 | Sentence | denotes | Results |
T11 | 539-695 | Sentence | denotes | We observed increased ACE2 expression in COPD patients who are overweight (mean BMI 29 kg/m2) compared to those notoverweight (mean BMI 21 kg/m2) (p=0.004). |
T12 | 697-707 | Sentence | denotes | Conclusion |
T13 | 708-800 | Sentence | denotes | Increased ACE2 expression may cause increased SARS‐CoV‐2 infection of the respiratory tract. |
T14 | 801-887 | Sentence | denotes | COPD patients who are overweight may be at greater risk of developing severe COVID‐19. |