Just as for hydroxychloroquine, the pharmacokinetic parameters of azithromycin confirm these extreme distribution properties. The volume of distribution of azithromycin was reported to be 31 L/kg and the half-life was 68 h, despite a relatively rapid clearance of 630 mL/min [18]. Furthermore, the pharmacokinetics of azithromycin have been shown to be affected by the disease state [19]. In a preclinical investigation, azithromycin was injected into rats and interstitial concentrations were measured in both thighs using microdialysis. After 3 h, an infection was induced in only one leg. Shortly after, the unbound interstitial tissue concentrations increased in the infected leg, without any additional dosing. The results can be explained by macrophages loaded with lysosomal azithromycin migrating to and releasing drug at the infection site.