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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 36-54 Chemical denotes hydroxychloroquine MESH:D006886
3 59-71 Chemical denotes azithromycin MESH:D017963
13 175-183 Species denotes patients Tax:9606
14 207-225 Chemical denotes hydroxychloroquine MESH:D006886
15 230-242 Chemical denotes azithromycin MESH:D017963
16 471-489 Chemical denotes hydroxychloroquine MESH:D006886
17 494-506 Chemical denotes azithromycin MESH:D017963
18 987-999 Chemical denotes azithromycin MESH:D017963
19 1160-1178 Chemical denotes hydroxychloroquine MESH:D006886
20 1183-1195 Chemical denotes azithromycin MESH:D017963
21 166-174 Disease denotes COVID-19 MESH:C000657245
26 1579-1587 Species denotes patients Tax:9606
27 1611-1629 Chemical denotes hydroxychloroquine MESH:D006886
28 1634-1646 Chemical denotes azithromycin MESH:D017963
29 1570-1578 Disease denotes COVID-19 MESH:C000657245
33 2677-2695 Chemical denotes hydroxychloroquine MESH:D006886
34 2700-2712 Chemical denotes azithromycin MESH:D017963
35 2758-2767 Chemical denotes nitrogens MESH:D009584
44 2071-2089 Chemical denotes hydroxychloroquine MESH:D006886
45 2094-2106 Chemical denotes azithromycin MESH:D017963
46 2279-2285 Chemical denotes amines MESH:D000588
47 2369-2381 Chemical denotes Azithromycin MESH:D017963
48 2390-2399 Chemical denotes nitrogens MESH:D009584
49 2436-2454 Chemical denotes Hydroxychloroquine MESH:D006886
50 2465-2474 Chemical denotes nitrogens MESH:D009584
51 2538-2547 Chemical denotes nitrogens MESH:D009584
53 5270-5277 Chemical denotes dibasic
56 2864-2873 Chemical denotes nitrogens MESH:D009584
57 4225-4227 Chemical denotes H2 MESH:D003903
61 6259-6262 Gene denotes Ka1 Gene:2900
62 6267-6270 Gene denotes Ka2 Gene:2901
63 5614-5623 Chemical denotes nitrogens MESH:D009584
65 6581-6599 Chemical denotes Hydroxychloroquine MESH:D006886
70 6649-6667 Chemical denotes hydroxychloroquine MESH:D006886
71 6912-6930 Chemical denotes hydroxychloroquine MESH:D006886
72 7078-7096 Chemical denotes hydroxychloroquine MESH:D006886
73 7457-7475 Chemical denotes hydroxychloroquine MESH:D006886
75 7578-7590 Chemical denotes Azithromycin MESH:D017963
83 7642-7654 Chemical denotes azithromycin MESH:D017963
84 7786-7804 Chemical denotes hydroxychloroquine MESH:D006886
85 7830-7842 Chemical denotes azithromycin MESH:D017963
86 7928-7941 Chemical denotes phospholipids MESH:D010743
87 7992-8004 Chemical denotes azithromycin MESH:D017963
88 8091-8103 Chemical denotes azithromycin MESH:D017963
89 8227-8239 Chemical denotes azithromycin MESH:D017963
100 9298-9302 Species denotes rats Tax:10116
101 8858-8876 Chemical denotes hydroxychloroquine MESH:D006886
102 8912-8924 Chemical denotes azithromycin MESH:D017963
103 9002-9014 Chemical denotes azithromycin MESH:D017963
104 9164-9176 Chemical denotes azithromycin MESH:D017963
105 9267-9279 Chemical denotes azithromycin MESH:D017963
106 9628-9640 Chemical denotes azithromycin MESH:D017963
107 9399-9408 Disease denotes infection MESH:D007239
108 9517-9525 Disease denotes infected MESH:D007239
109 9680-9689 Disease denotes infection MESH:D007239
115 9801-9819 Chemical denotes hydroxychloroquine MESH:D006886
116 9824-9836 Chemical denotes azithromycin MESH:D017963
117 9940-9951 Chemical denotes chloroquine MESH:D002738
118 10002-10013 Chemical denotes chloroquine MESH:D002738
119 10018-10036 Chemical denotes hydroxychloroquine MESH:D006886
128 10500-10511 Chemical denotes chloroquine MESH:D002738
129 10516-10528 Chemical denotes azithromycin MESH:D017963
130 10607-10625 Chemical denotes Hydroxychloroquine MESH:D006886
131 10630-10641 Chemical denotes chloroquine MESH:D002738
132 10690-10708 Chemical denotes hydroxychloroquine MESH:D006886
133 10791-10802 Chemical denotes chloroquine MESH:D002738
134 10572-10579 Disease denotes malaria MESH:D008288
135 10672-10679 Disease denotes malaria MESH:D008288
138 10895-10906 Chemical denotes chloroquine MESH:D002738
139 10911-10923 Chemical denotes azithromycin MESH:D017963
147 11187-11204 Species denotes Chikungunya virus Tax:37124
148 11292-11303 Species denotes coronavirus Tax:11118
149 11344-11352 Species denotes SARS-CoV Tax:694009
150 11511-11519 Species denotes SARS-CoV Tax:694009
151 11897-11907 Species denotes SARS-CoV-2 Tax:2697049
152 10925-10936 Chemical denotes Chloroquine MESH:D002738
153 11131-11142 Chemical denotes chloroquine MESH:D002738
173 12320-12330 Species denotes rhinovirus Tax:12059
174 12337-12364 Species denotes respiratory syncytial virus Tax:12814
175 12376-12391 Species denotes influenza virus Tax:11309
176 12332-12334 Species denotes RV Tax:12059
177 12366-12369 Species denotes RSV Tax:12814
178 12481-12484 Species denotes RSV Tax:12814
179 12517-12520 Species denotes RSV Tax:12814
180 12560-12563 Species denotes RSV Tax:12814
181 11914-11924 Chemical denotes Macrolides MESH:D018942
182 11933-11945 Chemical denotes azithromycin MESH:D017963
183 12266-12276 Chemical denotes macrolides MESH:D018942
184 12393-12403 Chemical denotes Macrolides MESH:D018942
185 12594-12604 Chemical denotes macrolides MESH:D018942
186 12663-12673 Chemical denotes macrolides MESH:D018942
187 12173-12201 Disease denotes respiratory viral infections
188 12280-12308 Disease denotes respiratory viral infections
189 12485-12494 Disease denotes infection MESH:D007239
190 12564-12573 Disease denotes infection MESH:D007239
191 12618-12633 Disease denotes virus infection MESH:D001102
219 13823-13859 Gene denotes QTcF were 5 (10) ms, 7 (12) ms and 9
220 13978-13982 Species denotes pigs Tax:9823
221 12961-12979 Chemical denotes Hydroxychloroquine MESH:D006886
222 13330-13342 Chemical denotes azithromycin MESH:D017963
223 13360-13371 Chemical denotes chloroquine MESH:D002738
224 13506-13517 Chemical denotes chloroquine MESH:D002738
225 13562-13574 Chemical denotes azithromycin MESH:D017963
226 13644-13656 Chemical denotes azithromycin MESH:D017963
227 13745-13756 Chemical denotes chloroquine MESH:D002738
228 13926-13938 Chemical denotes azithromycin MESH:D017963
229 13997-14009 Chemical denotes azithromycin MESH:D017963
230 14010-14021 Chemical denotes chloroquine MESH:D002738
231 14118-14130 Chemical denotes azithromycin MESH:D017963
232 14135-14146 Chemical denotes chloroquine MESH:D002738
233 14317-14329 Chemical denotes azithromycin MESH:D017963
234 14335-14346 Chemical denotes chloroquine MESH:D002738
235 14371-14382 Chemical denotes chloroquine MESH:D002738
236 14483-14494 Chemical denotes chloroquine MESH:D002738
237 14499-14511 Chemical denotes azithromycin MESH:D017963
238 14580-14598 Chemical denotes hydroxychloroquine MESH:D006886
239 12857-12884 Disease denotes Prolongation of QT interval MESH:D008133
240 12898-12917 Disease denotes torsades de pointes MESH:D016171
241 13130-13149 Disease denotes cardiac arrhythmias MESH:D001145
242 13199-13222 Disease denotes ventricular arrhythmias MESH:D001145
243 13373-13398 Disease denotes QTc interval prolongation MESH:D008133
244 14740-14750 Disease denotes infections MESH:D007239
245 14838-14847 Disease denotes infection MESH:D007239
249 15473-15484 Chemical denotes chloroquine MESH:D002738
250 15489-15501 Chemical denotes azithromycin MESH:D017963
251 15544-15562 Chemical denotes hydroxychloroquine MESH:D006886
255 15602-15620 Chemical denotes hydroxychloroquine MESH:D006886
256 15626-15638 Chemical denotes azithromycin MESH:D017963
257 15689-15694 Disease denotes COVID MESH:C000657245

2_test

Id Subject Object Predicate Lexical cue
32389720-20385873-48149092 2432-2433 20385873 denotes 5
32389720-28962308-48149093 2512-2513 28962308 denotes 6
32389720-23378628-48149094 3693-3694 23378628 denotes 7
32389720-3067757-48149095 3695-3696 3067757 denotes 8
32389720-3067757-48149096 4088-4089 3067757 denotes 8
32389720-3179169-48149097 7178-7179 3179169 denotes 9
32389720-7558665-48149098 7943-7945 7558665 denotes 10
32389720-12441132-48149099 7949-7951 12441132 denotes 11
32389720-11499789-48149100 7955-7957 11499789 denotes 12
32389720-8957238-48149101 7961-7963 8957238 denotes 13
32389720-25155592-48149102 8029-8031 25155592 denotes 14
32389720-25155592-48149103 8680-8682 25155592 denotes 14
32389720-431047-48149104 8686-8688 431047 denotes 15
32389720-12243724-48149105 8692-8694 12243724 denotes 16
32389720-1030706-48149106 8698-8700 1030706 denotes 17
32389720-20219329-48149107 9230-9232 20219329 denotes 19
32389720-3373422-48149108 9970-9972 3373422 denotes 20
32389720-4607946-48149109 9973-9975 4607946 denotes 21
32389720-3179169-48149110 10072-10073 3179169 denotes 9
32389720-6169733-48149111 10278-10280 6169733 denotes 22
32389720-16525098-48149112 10599-10601 16525098 denotes 23
32389720-12121927-48149113 10602-10604 12121927 denotes 24
32389720-17629679-48149114 10816-10818 17629679 denotes 27
32389720-15140961-48149115 11356-11358 15140961 denotes 29
32389720-21435673-48149116 11909-11911 21435673 denotes 30
32389720-24632748-48149117 12203-12205 24632748 denotes 31
32389720-17984356-48149118 14073-14075 17984356 denotes 34
32389720-16525098-48149119 14210-14212 16525098 denotes 23
T55575 2432-2433 20385873 denotes 5
T26778 2512-2513 28962308 denotes 6
T71350 3693-3694 23378628 denotes 7
T29944 3695-3696 3067757 denotes 8
T50414 4088-4089 3067757 denotes 8
T38067 7178-7179 3179169 denotes 9
T35193 7943-7945 7558665 denotes 10
T71814 7949-7951 12441132 denotes 11
T86676 7955-7957 11499789 denotes 12
T46347 7961-7963 8957238 denotes 13
T79422 8029-8031 25155592 denotes 14
T99834 8680-8682 25155592 denotes 14
T30874 8686-8688 431047 denotes 15
T42597 8692-8694 12243724 denotes 16
T58158 8698-8700 1030706 denotes 17
T92937 9230-9232 20219329 denotes 19
T86116 9970-9972 3373422 denotes 20
T74291 9973-9975 4607946 denotes 21
T92048 10072-10073 3179169 denotes 9
T72881 10278-10280 6169733 denotes 22
T9782 10599-10601 16525098 denotes 23
T33122 10602-10604 12121927 denotes 24
T54375 10816-10818 17629679 denotes 27
T17850 11356-11358 15140961 denotes 29
T68010 11909-11911 21435673 denotes 30
T88710 12203-12205 24632748 denotes 31
T56518 14073-14075 17984356 denotes 34
T30823 14210-14212 16525098 denotes 23

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 10-19 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T2 576-585 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T3 722-731 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T4 749-758 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T5 791-800 Body_part denotes cytosolic http://purl.org/sig/ont/fma/fma66836
T6 1239-1248 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T7 1390-1399 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T8 2773-2782 Body_part denotes Lysosomal http://purl.org/sig/ont/fma/fma63836
T9 3063-3070 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T10 3103-3112 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T11 3417-3425 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T12 3470-3478 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T13 3528-3532 Body_part denotes back http://purl.org/sig/ont/fma/fma25056
T14 3542-3549 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T15 3618-3627 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T16 3888-3895 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T17 3909-3917 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T18 4527-4536 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T19 4600-4609 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T20 4857-4865 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T21 4910-4918 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T22 4968-4972 Body_part denotes back http://purl.org/sig/ont/fma/fma25056
T23 4982-4989 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T24 5062-5071 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T25 5093-5102 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T26 5381-5390 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T27 5401-5408 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T28 5674-5682 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T29 5683-5687 Body_part denotes back http://purl.org/sig/ont/fma/fma25056
T30 5697-5704 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T31 5811-5819 Body_part denotes lysosome http://purl.org/sig/ont/fma/fma63836
T32 5949-5953 Body_part denotes back http://purl.org/sig/ont/fma/fma25056
T33 5961-5968 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T34 6522-6531 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T35 6704-6713 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T36 6728-6735 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T37 6839-6848 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T38 6944-6950 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T39 7222-7226 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T40 7242-7249 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T41 7311-7320 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T42 7503-7508 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T43 7691-7700 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T44 7715-7722 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T45 7888-7897 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T46 7928-7941 Body_part denotes phospholipids http://purl.org/sig/ont/fma/fma82779
T47 8005-8014 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T48 8140-8157 Body_part denotes white blood cells http://purl.org/sig/ont/fma/fma62852
T49 8152-8157 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T50 8274-8281 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T51 8356-8362 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T52 8439-8456 Body_part denotes white blood cells http://purl.org/sig/ont/fma/fma62852
T53 8451-8456 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T54 8540-8558 Body_part denotes interstitial space http://purl.org/sig/ont/fma/fma17555
T55 8576-8585 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T56 8669-8673 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T57 8770-8779 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T58 9433-9436 Body_part denotes leg http://purl.org/sig/ont/fma/fma24979
T59 9478-9484 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T60 9526-9529 Body_part denotes leg http://purl.org/sig/ont/fma/fma24979
T61 9594-9605 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T62 9618-9627 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T63 9882-9891 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T64 10121-10130 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T65 10240-10249 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T66 10264-10273 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T67 10415-10424 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T68 11028-11036 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T69 11120-11129 Body_part denotes endosomes http://purl.org/sig/ont/fma/fma67180
T70 11224-11229 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T71 11316-11321 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T72 11396-11405 Body_part denotes endosomes http://purl.org/sig/ont/fma/fma67180
T73 11454-11463 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T74 11522-11528 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T75 11538-11545 Body_part denotes cytosol http://purl.org/sig/ont/fma/fma66836
T76 11610-11619 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T77 11620-11631 Body_part denotes compartment http://purl.org/sig/ont/fma/fma76577
T78 11830-11839 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T79 12448-12457 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T80 12510-12513 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T81 12654-12659 Body_part denotes IL-12 http://purl.org/sig/ont/fma/fma86579
T82 14966-14972 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T83 14997-15001 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T84 15002-15007 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T85 15275-15284 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 7503-7508 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 8146-8151 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T3 8445-8450 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T4 9433-9436 Body_part denotes leg http://purl.obolibrary.org/obo/UBERON_0000978
T5 9465-9484 Body_part denotes interstitial tissue http://purl.obolibrary.org/obo/UBERON_0005169
T6 9478-9484 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T7 9526-9529 Body_part denotes leg http://purl.obolibrary.org/obo/UBERON_0000978
T8 14966-14972 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T9 14997-15001 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T10 15002-15007 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 166-174 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 1570-1578 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 3317-3319 Disease denotes BH http://purl.obolibrary.org/obo/MONDO_0010873
T4 3502-3504 Disease denotes BH http://purl.obolibrary.org/obo/MONDO_0010873
T5 4759-4761 Disease denotes BH http://purl.obolibrary.org/obo/MONDO_0010873
T6 4942-4944 Disease denotes BH http://purl.obolibrary.org/obo/MONDO_0010873
T7 8379-8387 Disease denotes subcutis http://purl.obolibrary.org/obo/MONDO_0006591
T8 9399-9408 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T9 9680-9689 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T10 10572-10579 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T11 10672-10679 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T12 11187-11198 Disease denotes Chikungunya http://purl.obolibrary.org/obo/MONDO_0017941
T13 11344-11352 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 11511-11519 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 11733-11743 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T16 11897-11905 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 12185-12201 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T18 12292-12308 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T19 12376-12385 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T20 12485-12501 Disease denotes infection, viral http://purl.obolibrary.org/obo/MONDO_0005108
T21 12485-12494 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T22 12564-12573 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T23 12608-12617 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T24 12618-12633 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T25 12624-12633 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T26 12898-12917 Disease denotes torsades de pointes http://purl.obolibrary.org/obo/MONDO_0005478
T27 13138-13149 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T28 13211-13222 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263
T29 14740-14750 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T30 14838-14847 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 10-19 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T2 82-83 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T3 190-191 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 360-361 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 576-585 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T6 599-602 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T7 622-623 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 650-658 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T9 722-731 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T10 749-758 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T11 1239-1248 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T12 1390-1399 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T13 1594-1595 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 1928-1929 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T15 1997-2005 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T16 2187-2188 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 2382-2385 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T18 2455-2458 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T19 2773-2782 http://purl.obolibrary.org/obo/GO_0005764 denotes Lysosomal
T20 2951-2960 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T21 3103-3112 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T22 3223-3224 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T23 3252-3253 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T24 3277-3286 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T25 3292-3293 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 3347-3356 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T27 3417-3425 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T28 3470-3478 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T29 3554-3555 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T30 3618-3627 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T31 3660-3663 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T32 3909-3917 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T33 4120-4123 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T34 4371-4372 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T35 4426-4427 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T36 4527-4536 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T37 4600-4609 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T38 4665-4666 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T39 4694-4695 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T40 4719-4728 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T41 4734-4735 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T42 4789-4798 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T43 4855-4856 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T44 4857-4865 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T45 4910-4918 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T46 4994-4995 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T47 5062-5071 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T48 5093-5102 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T49 5170-5171 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T50 5192-5193 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T51 5268-5269 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T52 5288-5289 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T53 5359-5360 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T54 5381-5390 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T55 5674-5682 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T56 5811-5819 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosome
T57 6373-6374 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T58 6522-6531 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T59 6704-6713 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T60 6795-6796 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T61 6839-6848 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T62 6944-6950 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T63 7311-7320 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T64 7503-7508 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T65 7503-7508 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T66 7534-7535 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T67 7691-7700 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T68 7740-7742 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T69 7844-7845 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T70 7888-7897 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T71 7949-7951 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T72 7966-7967 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T73 8005-8014 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T74 8146-8157 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood cells
T75 8356-8362 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T76 8356-8362 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T77 8356-8362 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T78 8356-8362 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T79 8379-8387 http://purl.obolibrary.org/obo/UBERON_0002072 denotes subcutis
T80 8445-8456 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood cells
T81 8576-8585 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T82 8669-8678 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T83 8770-8779 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T84 8939-8946 http://www.ebi.ac.uk/efo/EFO_0000876 denotes extreme
T85 9078-9079 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T86 9122-9124 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T87 9238-9239 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T88 9357-9363 http://www.ebi.ac.uk/efo/EFO_0001943 denotes thighs
T89 9433-9436 http://www.ebi.ac.uk/efo/EFO_0001411 denotes leg
T90 9465-9484 http://purl.obolibrary.org/obo/UBERON_0005169 denotes interstitial tissue
T91 9526-9529 http://www.ebi.ac.uk/efo/EFO_0001411 denotes leg
T92 9618-9627 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T93 9753-9763 http://purl.obolibrary.org/obo/CLO_0009985 denotes is focused
T94 9838-9839 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T95 9882-9891 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T96 9918-9921 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T97 10121-10130 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T98 10240-10249 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T99 10264-10273 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T100 10278-10280 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T101 10415-10424 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T102 10580-10583 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T103 10709-10712 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T104 10713-10714 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T105 10816-10818 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T106 10973-10978 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T107 11079-11086 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T108 11199-11204 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T109 11219-11223 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T110 11219-11223 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T111 11224-11229 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T112 11239-11244 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T113 11255-11256 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T114 11316-11321 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T115 11365-11375 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T116 11464-11473 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T117 11585-11590 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T118 11610-11619 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T119 11830-11839 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T120 11846-11849 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T121 11867-11868 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T122 12154-12155 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T123 12359-12364 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T124 12386-12391 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T125 12618-12623 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T126 12706-12711 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T127 12810-12813 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T128 13414-13415 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T129 13465-13468 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T130 13618-13620 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T131 13687-13688 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T132 13840-13842 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T133 13851-13853 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T134 13865-13867 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T135 14073-14075 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T136 14081-14082 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 14666-14667 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T138 14997-15001 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T139 14997-15001 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T140 15002-15007 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T141 15002-15007 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T142 15029-15035 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T143 15125-15127 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T144 15275-15284 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T145 15386-15387 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T146 15579-15581 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T147 15735-15736 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T148 15947-15948 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 20-23 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T2 36-54 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T3 59-71 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T4 207-225 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T5 230-242 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T6 332-337 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T7 413-422 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T8 471-489 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T9 494-506 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T10 640-649 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T11 683-688 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T12 759-763 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T13 987-999 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T14 1075-1080 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T15 1117-1122 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T16 1160-1178 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T17 1183-1195 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T18 1352-1356 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T19 1374-1377 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T20 1469-1473 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T21 1611-1629 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T22 1634-1646 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T23 1790-1794 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T24 1900-1905 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T25 2071-2089 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T26 2094-2106 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T27 2279-2285 Chemical denotes amines http://purl.obolibrary.org/obo/CHEBI_32952
T28 2677-2695 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T29 2700-2712 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T30 2783-2786 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T31 3036-3041 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T32 3375-3379 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T33 3646-3649 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T34 4139-4144 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T35 4225-4227 Chemical denotes H2 http://purl.obolibrary.org/obo/CHEBI_18276
T36 4247-4253 Chemical denotes proton http://purl.obolibrary.org/obo/CHEBI_24636
T37 4610-4613 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T38 4817-4821 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T39 5103-5106 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T40 5470-5478 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T41 5871-5879 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T42 6002-6005 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T43 6140-6142 Chemical denotes H2 http://purl.obolibrary.org/obo/CHEBI_18276
T44 6163-6165 Chemical denotes H2 http://purl.obolibrary.org/obo/CHEBI_18276
T45 6185-6191 Chemical denotes proton http://purl.obolibrary.org/obo/CHEBI_24636
T46 6649-6667 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T47 6783-6787 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T48 6912-6930 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T49 7078-7096 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T50 7210-7214 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T51 7457-7475 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T52 7605-7608 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T53 7642-7654 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T54 7786-7804 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T55 7830-7842 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T56 7928-7941 Chemical denotes phospholipids http://purl.obolibrary.org/obo/CHEBI_16247
T57 7992-8004 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T58 8091-8103 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T59 8227-8239 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T60 8858-8876 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T61 8912-8924 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T62 9002-9014 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T63 9164-9176 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T64 9267-9279 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T65 9628-9640 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T66 9668-9672 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T67 9801-9819 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T68 9824-9836 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T69 9940-9951 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T70 10002-10013 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T71 10018-10036 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T72 10112-10117 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T73 10229-10234 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T74 10434-10440 Chemical denotes proton http://purl.obolibrary.org/obo/CHEBI_24636
T75 10500-10511 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T76 10516-10528 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T77 10630-10641 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T78 10690-10708 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T79 10791-10802 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T80 10875-10884 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T81 10895-10906 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T82 10911-10923 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T83 10925-10936 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T84 11131-11142 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T85 11565-11579 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T86 11565-11574 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T87 11575-11579 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T88 11744-11756 Chemical denotes nucleic acid http://purl.obolibrary.org/obo/CHEBI_33696
T89 11752-11756 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T90 11933-11945 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T91 11969-11989 Chemical denotes antibacterial agents http://purl.obolibrary.org/obo/CHEBI_33282
T92 12266-12276 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T93 12332-12334 Chemical denotes RV http://purl.obolibrary.org/obo/CHEBI_73823
T94 12594-12604 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T95 12654-12656 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T97 12663-12673 Chemical denotes macrolides http://purl.obolibrary.org/obo/CHEBI_25106
T98 12762-12766 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T99 12770-12774 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T100 12946-12951 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T101 13090-13095 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T102 13230-13234 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T103 13283-13288 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T104 13330-13342 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T105 13360-13371 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T106 13506-13517 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T107 13562-13574 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T108 13623-13625 Chemical denotes Co http://purl.obolibrary.org/obo/CHEBI_27638
T109 13644-13656 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T110 13745-13756 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T111 13926-13938 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T112 13997-14009 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T113 14010-14021 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T114 14118-14130 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T115 14135-14146 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T116 14317-14329 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T117 14335-14346 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T118 14347-14352 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T119 14371-14382 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T120 14389-14394 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T121 14483-14494 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T122 14499-14511 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T123 14580-14598 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T124 15182-15187 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T125 15227-15230 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T126 15285-15289 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T127 15336-15341 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T128 15466-15471 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T129 15473-15484 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T130 15489-15501 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T131 15544-15562 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T132 15602-15620 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T133 15626-15638 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T134 15851-15856 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 10207-10213 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T2 10207-10213 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T3 10394-10407 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T4 12185-12201 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T5 12292-12308 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-71 Sentence denotes Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin
T2 73-81 Sentence denotes Abstract
T3 82-243 Sentence denotes A recent report identified significant reductions or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin.
T4 244-431 Sentence denotes The present communication discusses some common pharmacokinetic properties of these two drugs that may be linked to a potential underlying mechanism of action for these antiviral effects.
T5 432-659 Sentence denotes The physicochemical properties of both hydroxychloroquine and azithromycin are consistent with particularly high affinity for the intracellular lysosomal space, which has been implicated as a target site for antiviral activity.
T6 660-859 Sentence denotes The properties of both drugs predict dramatic accumulation in lysosomes, with calculated lysosomal drug concentrations that exceed cytosolic and extracellular concentrations by more than 50 000-fold.
T7 860-1000 Sentence denotes These predictions are consistent with previously reported experimentally measured cellular and extracellular concentrations of azithromycin.
T8 1001-1140 Sentence denotes This is also reflected in the very large volumes of distribution of these drugs, which are among the highest of all drugs currently in use.
T9 1141-1249 Sentence denotes The combination of hydroxychloroquine and azithromycin produces very high local concentrations in lysosomes.
T10 1250-1486 Sentence denotes The clinical significance of this observation is unclear; however, the magnitude of this mechanism of drug accumulation via ion-trapping in lysosomes could be an important factor for the pharmacodynamic effects of this drug combination.
T11 1488-1653 Sentence denotes Recent reports identified significant reduction or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin [1,2].
T12 1654-1811 Sentence denotes However, other clinical studies could not confirm these early findings [3] and there are considerable concerns about the safety of this drug combination [4].
T13 1812-2006 Sentence denotes The present communication discusses some common pharmacokinetic properties of these two drugs that may be linked to a potential underlying mechanism of action for their pharmacological activity.
T14 2008-2030 Sentence denotes 1 Chemical structures
T15 2031-2107 Sentence denotes Fig. 1 shows the chemical structures of hydroxychloroquine and azithromycin.
T16 2108-2248 Sentence denotes Although the two compounds are from two chemically distinct classes, they have a structural similarity that is pharmacokinetically relevant.
T17 2249-2368 Sentence denotes Both compounds are multibasic amines with pKa values that are susceptible to protonation in the physiological pH range.
T18 2369-2435 Sentence denotes Azithromycin has two nitrogens with pKa values of 8.1 and 8.8 [5].
T19 2436-2515 Sentence denotes Hydroxychloroquine has three nitrogens with pKa values of 4.0, 8.3 and 9.7 [6].
T20 2516-2646 Sentence denotes However, only the two nitrogens with the higher values (shown in circles in Fig. 1) are protonated under physiological conditions.
T21 2647-2713 Sentence denotes Fig. 1 Chemical structures of hydroxychloroquine and azithromycin.
T22 2714-2768 Sentence denotes The circles indicate the pH-sensitive basic nitrogens.
T23 2770-2795 Sentence denotes 2 Lysosomal ion-trapping
T24 2796-2961 Sentence denotes If the pH of the molecular environment is lower (more acidic), more nitrogens are protonated, which in turn hinders the now-charged moieties from crossing membranes.
T25 2962-3082 Sentence denotes This is particularly relevant for the intracellular distribution of basic drugs crossing between the cytosol (pH approx.
T26 3083-3130 Sentence denotes 7.4) and the acidic lysosomal space (pH approx.
T27 3131-3136 Sentence denotes 5.0).
T28 3137-3181 Sentence denotes Fig. 2 shows this distribution conceptually.
T29 3182-3357 Sentence denotes Basic compounds are in an equilibrium of a less polar unionized form (B) that can easily cross membranes, and a polar protonated form (BH+) that cannot easily cross membranes.
T30 3358-3550 Sentence denotes As the unionized drug enters the acidic environment of the lysosome, it will be protonated and ‘trapped’ in the lysosome as the protonated form BH+ cannot easily diffuse back into the cytosol.
T31 3551-3628 Sentence denotes As a result, high concentrations of the compound can accumulate in lysosomes.
T32 3629-3698 Sentence denotes This concept of “ion-trapping” has been described and reviewed [7,8].
T33 3699-3928 Sentence denotes The magnitude of this accumulation depends on the mathematical relationship of the pKa of the compound of interest, its permeability, and the pH gradient between the two environments (e.g. cytosol [pH 7.4] and lysosome [pH 5.0]).
T34 3929-4091 Sentence denotes If there is no permeability limitation, the expected ratio or concentration gradient can be calculated based on the well-known Henderson-Hasselbalch equation [8].
T35 4092-4363 Sentence denotes If the compound of interest has only one basic group, the ratio between the concentrations will be:(1) R=C1C2=H1+KaH2+Kawhere H1 and H2 are the respective proton concentrations (=10−pH) of the two environments (pH 5 and 7.4) and Ka is the dissociation constant (=10−pKa).
T36 4364-4470 Sentence denotes Fig. 3 A shows the magnitude of the resulting accumulation as a function of the pKa value of the compound.
T37 4471-4581 Sentence denotes Accumulation of up to 250-fold higher concentrations in lysosomes can be explained by the described mechanism.
T38 4582-4623 Sentence denotes Fig. 2 Concept of lysosomal ion-trapping.
T39 4624-4799 Sentence denotes Basic compounds are in an equilibrium of a less polar unionized form (B) that can easily cross membranes, and a polar protonated form (BH+) that cannot easily cross membranes.
T40 4800-4990 Sentence denotes As the unionized drug enters the acidic environment of a lysosome, it will be protonated and ‘trapped’ in the lysosome as the protonated form BH+ cannot easily diffuse back into the cytosol.
T41 4991-5072 Sentence denotes As a result, high concentrations of the compound can accumulate in the lysosomes.
T42 5073-5165 Sentence denotes Fig. 3 Magnitude of lysosomal ion-trapping depending on the pKa of the compound of interest.
T43 5166-5263 Sentence denotes For a monobasic compound (A), up to 250-fold higher concentrations are possible depending on pKa.
T44 5264-5333 Sentence denotes For a dibasic compound (B), the accumulation can be over 60 000-fold.
T45 5334-5410 Sentence denotes These simulations assume a pH gradient of 5.0 (lysosomes) and 7.4 (cytosol).
T46 5411-5520 Sentence denotes However, in cases where there are two basic centers in the molecule, this effect is considerably potentiated.
T47 5521-5705 Sentence denotes There are two different monobasic species that are produced by protonation of the respective nitrogens, and neither of these can easily diffuse from the lysosome back into the cytosol.
T48 5706-5820 Sentence denotes Furthermore, both species are in equilibrium with the biprotonated species, which is also trapped in the lysosome.
T49 5821-5969 Sentence denotes Therefore, there are three different forms of the molecule (two monoprotonated and one biprotonated) that cannot easily diffuse back to the cytosol.
T50 5970-6022 Sentence denotes This tremendously magnifies the ion-trapping effect.
T51 6023-6311 Sentence denotes The expected accumulation ratio under these conditions is calculated as follows:(2) R=C1C2=H12+Ka1*H1+Ka1*Ka2H22+Ka1*H2+Ka1*Ka2where H1 and H2 are the respective proton concentrations (=10−pH) of the two environments (pH 5 and 7.4) and Ka1 and Ka2 are the dissociation constant (=10−pKa).
T52 6312-6458 Sentence denotes Fig. 3B shows the magnitude of the resulting accumulation as a function of the pKa value of the compound, assuming equal values for pKa1 and pKa2.
T53 6459-6576 Sentence denotes Accumulation of up to 60 000-fold higher concentrations in the lysosomes can be explained by the described mechanism.
T54 6578-6599 Sentence denotes 3 Hydroxychloroquine
T55 6600-6849 Sentence denotes When the above described concepts are applied to hydroxychloroquine, the expected accumulation ratio in lysosomes compared with cytosol is calculated as 56 000-fold; therefore, after drug intake a large fraction of the dose will reside in lysosomes.
T56 6850-6966 Sentence denotes This is confirmed by the known pharmacokinetic parameters for hydroxychloroquine derived from plasma concentrations.
T57 6967-7181 Sentence denotes After intravenous administration to healthy volunteers (average weight 63.5 kg), the volume of distribution of hydroxychloroquine was reported to be over 44 000 L, which is equivalent to approximately 700 L/kg [9].
T58 7182-7340 Sentence denotes This means that most of the drug in the body resides in the tissues, which is consistent with the predicted extraordinarily high lysosomal accumulation ratio.
T59 7341-7441 Sentence denotes Furthermore, it explains the very long half-life (approximately 40 days) reported in the same study.
T60 7442-7573 Sentence denotes In this study, hydroxychloroquine could still be detected in blood more than 6 months after a single dose administration of 310 mg.
T61 7575-7590 Sentence denotes 4 Azithromycin
T62 7591-7805 Sentence denotes When the same ion-trapping concepts are applied to azithromycin, the expected accumulation ratio in lysosomes compared with cytosol is calculated as 52 000-fold, which is very similar to that of hydroxychloroquine.
T63 7806-7965 Sentence denotes After administration of azithromycin, a large fraction of the dose will reside in lysosomes where it also binds to acidic phospholipids [10], [11], [12], [13].
T64 7966-8033 Sentence denotes A clinical study supports azithromycin lysosomal accumulation [14].
T65 8034-8187 Sentence denotes In this study, the experimentally measured average total azithromycin concentrations in polymorphonuclear white blood cells (PMLs) was over 14 000 ng/mL.
T66 8188-8400 Sentence denotes However, the model-predicted unionized azithromycin concentration of 6.0 ng/mL in the cytosol of PMLs was comparable to the measured interstitial concentrations in the muscle (8.7 ng/mL) and subcutis (4.1 ng/mL).
T67 8401-8559 Sentence denotes Hence, the measured concentrations in white blood cells was approximately 2000-fold higher than the measured unbound concentrations in the interstitial space.
T68 8560-8845 Sentence denotes Considering the lysosomal volume is estimated to range between 0.5 to 5% of the cellular volume depending on cell type [14], [15], [16], [17], these concentrations are consistent with the expected magnitude of lysosomal accumulation and explain these very high cellular concentrations.
T69 8846-8971 Sentence denotes Just as for hydroxychloroquine, the pharmacokinetic parameters of azithromycin confirm these extreme distribution properties.
T70 8972-9126 Sentence denotes The volume of distribution of azithromycin was reported to be 31 L/kg and the half-life was 68 h, despite a relatively rapid clearance of 630 mL/min [18].
T71 9127-9234 Sentence denotes Furthermore, the pharmacokinetics of azithromycin have been shown to be affected by the disease state [19].
T72 9235-9384 Sentence denotes In a preclinical investigation, azithromycin was injected into rats and interstitial concentrations were measured in both thighs using microdialysis.
T73 9385-9437 Sentence denotes After 3 h, an infection was induced in only one leg.
T74 9438-9561 Sentence denotes Shortly after, the unbound interstitial tissue concentrations increased in the infected leg, without any additional dosing.
T75 9562-9695 Sentence denotes The results can be explained by macrophages loaded with lysosomal azithromycin migrating to and releasing drug at the infection site.
T76 9697-9725 Sentence denotes 5 Discussion and conclusion
T77 9726-9977 Sentence denotes Although the present paper is focused on the pharmacokinetic properties of hydroxychloroquine and azithromycin, a similar intracellular accumulation in the lysosomal space can be expected and has been reported for chloroquine as early as 1974 [20,21].
T78 9978-10075 Sentence denotes The pharmacokinetics of chloroquine and hydroxychloroquine have been described to be similar [9].
T79 10076-10189 Sentence denotes The very high accumulation of these drugs in lysosomes produces very high local concentrations of both compounds.
T80 10190-10282 Sentence denotes Furthermore, the uptake of these basic drugs into lysosomes increases the lysosomal pH [22].
T81 10283-10480 Sentence denotes However, it is difficult to estimate the magnitude and time course of this alkalization as there is continuous acidification of the lysosomal space by proton pumps that function to maintain low pH.
T82 10481-10606 Sentence denotes The combination of chloroquine and azithromycin is not new, and synergistic effect against malaria has been reported [23,24].
T83 10607-10680 Sentence denotes Hydroxychloroquine and chloroquine have similar efficacy against malaria.
T84 10681-10820 Sentence denotes Although hydroxychloroquine has a preferred safety profile, more pharmacodynamic information is available for chloroquine [25], [26], [27].
T85 10821-10924 Sentence denotes Several studies point to mechanisms for the potential antiviral action of chloroquine and azithromycin.
T86 10925-11092 Sentence denotes Chloroquine was shown to impair early stages of virus replication by interfering with the pH-dependent endosome-mediated viral entry of several different viruses [28].
T87 11093-11254 Sentence denotes Due to the alkalization of endosomes, chloroquine was an effective in vitro treatment against Chikungunya virus when added to Vero cells prior to virus exposure.
T88 11255-11360 Sentence denotes A pH-dependent mechanism of entry of coronavirus into target cells was also reported for SARS-CoV-1 [29].
T89 11361-11546 Sentence denotes The activation step that occurs in endosomes at acidic pH results in fusion of the viral and endosomal membranes, leading to the release of the viral SARS-CoV-1 genome into the cytosol.
T90 11547-11818 Sentence denotes In the absence of antiviral drug, the virus is targeted to the lysosomal compartment where the low pH, along with the action of enzymes, disrupts the viral particle, thus liberating the infectious nucleic acid and, in several cases, enzymes necessary for its replication.
T91 11819-11913 Sentence denotes Hence, the lysosomal space has been proposed as a major target site to tackle SARS-CoV-2 [30].
T92 11914-12104 Sentence denotes Macrolides such as azithromycin are very commonly used antibacterial agents; however, they have also received considerable attention for their anti-inflammatory and immunomodulatory actions.
T93 12105-12210 Sentence denotes These two properties may ensure some efficacy in a wide spectrum of respiratory viral infections [31,32].
T94 12211-12392 Sentence denotes Both in vitro and in vivo studies indicate efficacy of macrolides in respiratory viral infections, including rhinovirus (RV), respiratory syncytial virus (RSV), and influenza virus.
T95 12393-12574 Sentence denotes Macrolides also reduced the release of proinflammatory cytokines, which were induced by RSV infection, viral titers, RNA of RSV replication, and the susceptibility to RSV infection.
T96 12575-12738 Sentence denotes Similar effects of macrolides on influenza virus infection and augmentation of IL-12 by macrolides, which is essential in reducing virus yield, were reported [32].
T97 12739-12856 Sentence denotes As with the use of any drug or drug combination, the potential benefit has to be weighed against any safety concerns.
T98 12857-12960 Sentence denotes Prolongation of QT interval and cases of torsades de pointes have been reported for both drugs [18,33].
T99 12961-13155 Sentence denotes Hydroxychloroquine prolongs the QT interval and, according to its prescribing information, should not be administered with other drugs that have the potential to induce cardiac arrhythmias [33].
T100 13156-13293 Sentence denotes There may be an increased risk of inducing ventricular arrhythmias if the drug is used concomitantly with other arrhythmogenic drugs [4].
T101 13294-13372 Sentence denotes Most relevant interaction data with azithromycin is available for chloroquine.
T102 13373-13622 Sentence denotes QTc interval prolongation was studied in a randomized, placebo-controlled parallel trial in 116 healthy subjects who received either chloroquine (1000 mg) alone or in combination with oral azithromycin (500 mg, 1000 mg, and 1500 mg once daily) [18].
T103 13623-13730 Sentence denotes Co-administration of azithromycin increased the QTc interval in a dose- and concentration-dependent manner.
T104 13731-13953 Sentence denotes Compared with chloroquine alone, the maximum mean (95% upper confidence bound) increases in QTcF were 5 (10) ms, 7 (12) ms and 9 (14) ms with the co-administration of 500 mg, 1000 mg and 1500 mg azithromycin, respectively.
T105 13954-14077 Sentence denotes Furthermore, studies in pigs revealed that azithromycin/chloroquine combinations did not increase cardiac instability [34].
T106 14078-14214 Sentence denotes In a clinical interaction study between azithromycin and chloroquine, no clinically relevant pharmacokinetic changes were observed [23].
T107 14215-14259 Sentence denotes However, increases in QTc values were noted.
T108 14260-14449 Sentence denotes Although mean increases were numerically greater for the azithromycin plus chloroquine group compared with the chloroquine alone group, these differences were not statistically significant.
T109 14450-14554 Sentence denotes Administered alone and together, chloroquine and azithromycin were well tolerated overall in this study.
T110 14555-14751 Sentence denotes More investigations with hydroxychloroquine are needed as well as finetuning the optimum dosing regimen to get a clearer picture of the expected risk-benefit assessment in these severe infections.
T111 14752-14957 Sentence denotes These dose optimization attempts will have to utilize ways to estimate the respective infection site concentration; this is very challenging due to the tremendous differences in subcellular concentrations.
T112 14958-15129 Sentence denotes Average tissue concentrations based on lung/blood ratios obtained from animal studies have been proposed and applied but may not be appropriate for dose optimization [35].
T113 15130-15325 Sentence denotes The unusual pharmacokinetic properties of these two drugs may make them suitable partners for an ion-trapping-mediated mechanism of action where lysosomal drug accumulation delivers local action.
T114 15326-15382 Sentence denotes These two drugs have very large volumes of distribution.
T115 15383-15583 Sentence denotes In a widely used long list of pharmacokinetic properties of the most commonly used drugs, chloroquine and azithromycin have the largest volumes of distribution (hydroxychloroquine is not listed) [36].
T116 15584-15701 Sentence denotes Short-term use of hydroxychloroquine with azithromycin may have clinical impact early in the progress of COVID [1,2].
T117 15702-15827 Sentence denotes An early diagnosis combined with a safe and effective treatment before more serious symptoms occur would be highly desirable.
T118 15828-16021 Sentence denotes Both of these low-cost drugs have been widely used for decades with acceptable safety that could expedite rapid use if a clinical benefit is established in rigorous safety and efficacy studies.
T119 16022-16090 Sentence denotes These studies are currently ongoing and will provide solid guidance.
T120 16092-16107 Sentence denotes Acknowledgement
T121 16108-16239 Sentence denotes The fundamental contributions by and fruitful discussions with Prof. Paul Tulkens (UCLouvain, Belgium) are gratefully acknowledged.
T122 16241-16253 Sentence denotes Declarations
T123 16255-16263 Sentence denotes Funding:
T124 16264-16274 Sentence denotes No funding
T125 16276-16296 Sentence denotes Competing Interests:
T126 16297-16301 Sentence denotes None
T127 16303-16320 Sentence denotes Ethical Approval:
T128 16321-16333 Sentence denotes Not required

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 12857-12884 Phenotype denotes Prolongation of QT interval http://purl.obolibrary.org/obo/HP_0001657
T2 12898-12917 Phenotype denotes torsades de pointes http://purl.obolibrary.org/obo/HP_0001664
T3 12980-13004 Phenotype denotes prolongs the QT interval http://purl.obolibrary.org/obo/HP_0001657
T4 13130-13149 Phenotype denotes cardiac arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T5 13199-13222 Phenotype denotes ventricular arrhythmias http://purl.obolibrary.org/obo/HP_0004308
T6 14733-14750 Phenotype denotes severe infections http://purl.obolibrary.org/obo/HP_0032169