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PMC:7204657 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 0-11 Chemical denotes Tocilizumab MESH:C502936
3 15-23 Disease denotes COVID-19 MESH:C000657245
22 150-154 Gene denotes IL-6 Gene:3569
23 313-321 Species denotes patients Tax:9606
24 748-756 Species denotes patients Tax:9606
25 915-923 Species denotes patients Tax:9606
26 119-130 Chemical denotes tocilizumab MESH:C502936
27 262-273 Chemical denotes tocilizumab MESH:C502936
28 430-441 Chemical denotes Tocilizumab MESH:C502936
29 597-608 Chemical denotes tocilizumab MESH:C502936
30 830-841 Chemical denotes tocilizumab MESH:C502936
31 934-945 Chemical denotes tocilizumab MESH:C502936
32 243-251 Disease denotes COVID-19 MESH:C000657245
33 304-312 Disease denotes COVID-19 MESH:C000657245
34 502-522 Disease denotes rheumatoid arthritis MESH:D001172
35 527-547 Disease denotes giant cell arteritis MESH:D013700
36 662-680 Disease denotes infectious disease MESH:D003141
37 724-738 Disease denotes critically ill MESH:D016638
38 739-747 Disease denotes COVID-19 MESH:C000657245
39 981-995 Disease denotes diverticulitis MESH:D004238
49 1074-1105 Gene denotes angiotensin-converting enzyme 2 Gene:59272
50 1107-1111 Gene denotes ACE2 Gene:59272
51 1218-1222 Gene denotes ACE2 Gene:59272
52 1037-1042 Species denotes human Tax:9606
53 1060-1070 Species denotes SARS-CoV-2 Tax:2697049
54 1277-1287 Species denotes SARS-CoV-2 Tax:2697049
55 1235-1260 Disease denotes gastrointestinal symptoms MESH:D012817
56 1321-1346 Disease denotes gastrointestinal symptoms MESH:D012817
57 1356-1370 Disease denotes abdominal pain MESH:D015746
67 1949-1967 Gene denotes C-reactive protein Gene:1401
68 1969-1972 Gene denotes CRP Gene:1401
69 1461-1469 Species denotes patients Tax:9606
70 2041-2049 Species denotes patients Tax:9606
71 1711-1722 Chemical denotes tocilizumab MESH:C502936
72 1839-1850 Chemical denotes tocilizumab MESH:C502936
73 1437-1451 Disease denotes critically ill MESH:D016638
74 1452-1460 Disease denotes COVID-19 MESH:C000657245
75 1735-1743 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 44-54 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T2 164-172 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T3 194-202 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T4 533-537 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T5 843-853 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T6 889-899 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T7 1147-1157 Body_part denotes intestines http://purl.org/sig/ont/fma/fma7199
T8 1163-1173 Body_part denotes Intestinal http://purl.org/sig/ont/fma/fma7199
T9 1288-1291 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T10 1524-1534 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T11 1569-1579 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T12 1683-1693 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T13 1888-1898 Body_part denotes intestinal http://purl.org/sig/ont/fma/fma7199
T14 1960-1967 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1147-1157 Body_part denotes intestines http://purl.obolibrary.org/obo/UBERON_0000160

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 15-23 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 44-66 Disease denotes intestinal perforation http://purl.obolibrary.org/obo/MONDO_0006807
T3 243-251 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 304-312 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 502-522 Disease denotes rheumatoid arthritis http://purl.obolibrary.org/obo/MONDO_0008383
T6 513-522 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T7 527-547 Disease denotes giant cell arteritis http://purl.obolibrary.org/obo/MONDO_0008538
T8 538-547 Disease denotes arteritis http://purl.obolibrary.org/obo/MONDO_0043494
T9 662-680 Disease denotes infectious disease http://purl.obolibrary.org/obo/MONDO_0005550
T10 739-747 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 843-865 Disease denotes intestinal perforation http://purl.obolibrary.org/obo/MONDO_0006807
T12 889-911 Disease denotes intestinal perforation http://purl.obolibrary.org/obo/MONDO_0006807
T13 981-995 Disease denotes diverticulitis http://purl.obolibrary.org/obo/MONDO_0004235
T14 1060-1068 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 1277-1285 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 1452-1460 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 1683-1705 Disease denotes intestinal perforation http://purl.obolibrary.org/obo/MONDO_0006807
T18 1735-1743 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T19 1888-1910 Disease denotes intestinal perforation http://purl.obolibrary.org/obo/MONDO_0006807

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 44-54 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T2 44-54 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T3 132-133 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 327-328 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 533-537 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6 796-797 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 843-853 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T8 843-853 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T9 889-899 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T10 889-899 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T11 996-999 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T12 1014-1015 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 1037-1042 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T14 1147-1157 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestines
T15 1147-1157 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestines
T16 1163-1173 http://purl.obolibrary.org/obo/UBERON_0000160 denotes Intestinal
T17 1163-1173 http://www.ebi.ac.uk/efo/EFO_0000834 denotes Intestinal
T18 1524-1534 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T19 1524-1534 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T20 1569-1579 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T21 1569-1579 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T22 1683-1693 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T23 1683-1693 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal
T24 1888-1898 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestinal
T25 1888-1898 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestinal

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 119-130 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T2 150-152 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T4 262-273 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T5 597-608 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T6 830-841 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T7 934-945 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T8 1074-1085 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T9 1711-1722 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T10 1839-1850 Chemical denotes tocilizumab http://purl.obolibrary.org/obo/CHEBI_64360
T11 1960-1967 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T12 2123-2125 Chemical denotes NA http://purl.obolibrary.org/obo/CHEBI_33696

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 1174-1191 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T2 1174-1191 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T3 1866-1886 http://purl.obolibrary.org/obo/GO_0006953 denotes acute phase response

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-24 Sentence denotes Tocilizumab in COVID-19:
T2 25-66 Sentence denotes Beware the risk of intestinal perforation
T3 68-80 Sentence denotes Dear Editor,
T4 81-252 Sentence denotes Zhang et al. [1] discussed the use of tocilizumab, a monoclonal anti-IL-6 receptor antibody, in the treatment of cytokine release syndrome associated with severe COVID-19.
T5 253-429 Sentence denotes Although tocilizumab may be beneficial in selected COVID-19 patients with a counterproductive hyperinflammatory phenotype, the efficacy and safety of such treatment is unknown.
T6 430-548 Sentence denotes Tocilizumab is primarily used for rheumatological conditions, including rheumatoid arthritis and giant cell arteritis.
T7 549-757 Sentence denotes Rheumatologists have extensive experience using tocilizumab; however, this may not be the case for intensivists, infectious disease specialists, and other physicians treating critically ill COVID-19 patients.
T8 758-870 Sentence denotes Therefore, we would like to highlight a rare but feared complication of tocilizumab: intestinal perforation [2].
T9 871-1032 Sentence denotes The mechanism for intestinal perforation in patients receiving tocilizumab is not fully understood, but prior diverticulitis has been noted as a risk factor [2].
T10 1033-1162 Sentence denotes The human host receptor of SARS-CoV-2 is angiotensin-converting enzyme 2 (ACE2), which is highly expressed in the intestines [3].
T11 1163-1315 Sentence denotes Intestinal viral replication is likely considering the ACE2 expression, gastrointestinal symptoms and presence of SARS-CoV-2 RNA in fecal samples [4,5].
T12 1316-1423 Sentence denotes Some gastrointestinal symptoms, such as abdominal pain, are associated with increased disease severity [5].
T13 1424-1598 Sentence denotes Furthermore, critically ill COVID-19 patients may have altered hemodynamics, potentially leading to intestinal hypoperfusion that can compromise intestinal mucosal integrity.
T14 1599-1827 Sentence denotes More studies are required to evaluate whether these variables influence the risk of intestinal perforation with tocilizumab in critical COVID-19 cases; however, clinicians should be aware of the potential for this adverse event.
T15 1828-2050 Sentence denotes Lastly, as tocilizumab attenuates the acute phase response, intestinal perforation may not necessarily cause significant C-reactive protein (CRP) elevation and may initially go unnoticed in sedated and ventilated patients.
T16 2052-2064 Sentence denotes Declarations
T17 2065-2073 Sentence denotes Funding:
T18 2074-2078 Sentence denotes None
T19 2079-2099 Sentence denotes Competing Interests:
T20 2100-2104 Sentence denotes None
T21 2105-2125 Sentence denotes Ethical Approval: NA

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 44-66 Phenotype denotes intestinal perforation http://purl.obolibrary.org/obo/HP_0031368
T2 194-219 Phenotype denotes cytokine release syndrome http://purl.obolibrary.org/obo/HP_0033041
T3 502-522 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T4 538-547 Phenotype denotes arteritis http://purl.obolibrary.org/obo/HP_0012089
T5 843-865 Phenotype denotes intestinal perforation http://purl.obolibrary.org/obo/HP_0031368
T6 889-911 Phenotype denotes intestinal perforation http://purl.obolibrary.org/obo/HP_0031368
T7 1356-1370 Phenotype denotes abdominal pain http://purl.obolibrary.org/obo/HP_0002027
T8 1683-1705 Phenotype denotes intestinal perforation http://purl.obolibrary.org/obo/HP_0031368
T9 1866-1886 Phenotype denotes acute phase response http://purl.obolibrary.org/obo/HP_0033331
T10 1888-1910 Phenotype denotes intestinal perforation http://purl.obolibrary.org/obo/HP_0031368