Copper (Cu) is an essential dietary supplement in animal feeds, which plays an important role in maintaining the balance of all living organisms (1). An accumulation or deficiency of this element may result in significant side effects (2-5) since it participates in regulation of gene expression of oxidation enzymes and cell injury by taking part in oxidation of membrane thiol groups to disulphides (6). As reported, content of Cu in drinking water supply should be less than 2 mg/l (7). Ingested Cu is mainly stored in the liver and mobilized into the circulation and then is distributed to every tissue in the body (1). Cu deficiency is a risk factor of slowed growth, anaemia, impaired bone tissue formation, and cardiac fibrosis (6) as well as chronic lung inflammation (3). By contrast, excessive storage of Cu also induces inflammation-mediated immune response in multiple systemic organs including brain (4), liver and kidney (1, 2, 5).