In the past, several chip-based DNA and RNA amplification devices are reported. It goes beyond the scope of this paper to discuss the state-of-the-art of DNA amplification chips in-depth. There are several good review papers written on this topic [12,13,14,15,16,17,18,19,20]. Readers are referred to these for a comprehensive overview of the field. In this paper, the state-of-the-art is divided into several discussion points, i.e., the heating method, the temperature control method, and the substrate material and fabrication technique. These points will be discussed separately.