Table A1 EC50 and CE50 values for protamine and for ethylenediamine-based covalent PAMAM dendrimers (G0-G6) as heparin binders. Values were obtained by fitting the data in Figure 2a. The last column shows the relevant dosage, i.e., the mass of binder required to bind 100 international units (IU) of heparin (i.e., the clinical standard. Adapted from [33] with the permission of The Royal Society of Chemistry. Heparin Binder Charge EC50 (µM) CE50 Dose (mg Binder/100 Heparin IU) Protamine +24 2.34 ± 0.23 0.52 ± 0.05 0.32 ± 0.03 G0 +4 too weak too weak too weak G1 +8 10.10 ± 0.32 0.75 ± 0.02 0.44 ± 0.01 G2 +16 2.55 ± 0.32 0.38 ± 0.04 0.25 ± 0.03 G3 +32 1.33 ± 0.21 0.45 ± 0.02 0.32 ± 0.04 G4 +64 0.64 ± 0.04 0.38 ± 0.02 0.27 ± 0.02 G5 +256 0.22 ± 0.04 0.53 ± 0.09 0.39 ± 0.06