Prolonged l-dopa treatment presents a risk up to 45% for developing LID after 4–5 years. Dyskinesias appear as low-amplitude choreic movements, typically related to peak plasma concentrations of l-dopa. Their phenomenology can vary from dystonia to ballism and myoclonus, often becoming very disabling. According to their timing of onset related to l-dopa dosing, dyskinesias can be classified into peak-dose dyskinesias, off-dyskinesias, and biphasic dyskinesias. Peak-dose dyskinesias, which are the most common LID, occur generally during the highest plasma l-dopa concentration (20 min to 2 h after a dose). Off-dyskinesias, often noticed as painful foot dystonia, appear during off-states and they may be seen at first as “early-morning dystonia” [186]. Biphasic dyskinesias are less common, presenting both at the beginning and at the end of l-dopa dosing. In biphasic dyskinesias legs are mainly affected with stereotyped movements and with an evident alteration of gait. This type of LID develops mainly in male patients with early motor complications [187]. The management of LID remains challenging, requiring a delicate therapeutic balance optimizing l-dopa doses but with the risk of increased “off” time. Treatment can be based on strategies to prevent their onset, to modify dopaminergic therapy, and to provide more continuous dopaminergic stimulation using non-dopaminergic drugs [188].