An alternative therapeutic option for an overactive bladder is represented by Mirabegron (50 mg daily) [156,157]. This drug acts as an agonist on β3 adrenoceptors and it has no antimuscarinic action, therefore not impairing cognition. Large phase 3 Randomized Controlled Trials have assessed the efficacy of Mirabegron monotherapy [158]. No particular recommendations for patients’ age and sex have been reported, as the molecule appears very well tolerated even for long-term therapy, also due to the lack of antimuscarinic side effects [157].