2.2.6. Anticholinergics
Anticholinergics could represent another choice in therapeutic settings, although they represent less effective anti-parkinsonian agents than DAs. However, they seem to be effective in controlling tremors and in reducing rigidity [60]. Triphexyphenidil is one of the most commonly used. The stating dose should be 2 mg three times per day, which can be gradually increased up to 15 mg or more per day. Regarding the safety profile, because of their well-known neuropsychiatric side effects due to central receptor antagonism (such as confusion, decrease short term memory, hallucinations, and psychosis) their use is generally limited to young and cognitively intact patients.