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PMC:55322 JSONTXT

Divisions (33) JSON TSV

div. section text # proj. length # Ann.
0 TIAB A draft annotation and overview of the human genome Background The recent draft assembly of the huma 0 1362 0 show
1 Background The sequence of the human nuclear genome has been completed in draft form by an international public 0 2599 0 show
2 Results and discussion Combine and conquer Public attention surrounding completion of the draft human sequence has fostered 0 6284 0 show
3 Results and discussion Transcriptional units Our consolidated exonic index is of inherent biological interest, but it is de 0 4183 0 show
4 Results and discussion Comparison of gene counts Our count of 66,000-75,000 transcriptional units on the genome is consiste 0 4118 0 show
5 Results and discussion Gene map The placement of transcriptional units is not without error, as most genomic clones are unf 0 696 0 show
6 Results and discussion Functional annotation SWISS-PROT, TrEMBL, PIR (Protein Information Resource) and Pfam (Protein Famil 0 1816 0 show
7 Results and discussion Global tissue expression profiles During the assembly o UniGene [19], we retained the library source 0 2629 0 show
8 Results and discussion A global view of the human genome In keeping with the long-standing clinical importance of cytogenet 0 859 0 show
9 Results and discussion Density of genomic features The resulting corrected ideograms and six major genomic features are plo 0 2857 0 show
10 Results and discussion Comparison of cytogenetic bands We next examined the overall correspondence between cytobands and ex 0 1641 0 show
11 Results and discussion Gene density We analyzed the exonic sequence for each chromosome as given in Table 1. Figure 2a show 0 1389 0 show
12 Results and discussion Comparisons to genetic and radiation hybrid maps A total of 3,628 Genethon markers from the Marshfie 0 3138 0 show
13 Results and discussion Clusters and compartments The availability of the full assembly enables a comparison of the entire g 0 4995 0 show
14 Results and discussion Clustering of ontological groups We also examined the locations of all transcriptional units that ha 0 2148 0 show
15 Conclusions The human genome is a capacious resource that will support years of intensive investigation. The qua 0 3433 0 show
16 Materials and methods Exon identification The 26 June 2000 version of the repeat-masked draft sequences was downloaded fro 0 2132 0 show
17 Materials and methods Prediction of transcriptional units A set of Perl scripts was used to implement the algorithm descri 0 3537 0 show
18 Materials and methods Gene mapping A relational database was used to integrate multiple largely independent maps for the g 0 1787 0 show
19 Materials and methods Tissue-specific transcripts We noted the total number of ESTs contributed by each tissue to compute 0 440 0 show
20 Materials and methods Cytoband alignment G bands are known to be relatively AT-rich, but the precise relationship between 0 1166 0 show
21 Materials and methods Genomic feature correlations All 1 Mb intervals were combined to produce Table 4, but statistical te 0 573 0 show
22 Materials and methods Regional functional clustering Apparently significant clustering can arise from the fact that genes 0 1234 0 show
23 Additional data files Additional data files are available online as follows: transcriptional units; computational predicti 0 353 0 show
24 Caption-Figure 1 Overview map of features on the entire human genome, based on the working draft assembly (15 June 20 0 1972 0 show
25 Caption-Figure 2 Coding sequence density for human chromosomes. (a) The proportion of assembled sequence that is exon 0 284 0 show
26 Caption-Figure 3 Total number of embryo-specific genes (based on HINT clusters) for each chromosome. Chromosomes 13, 0 163 0 show
27 Caption-Figure 4 The correspondence between physical location and maps constructed using different mapping methods. ( 0 657 0 show
28 Caption-Figure 5 Repeat-masked chromosome sequences were divided into 1Mb segments and analyzed against the entire ch 0 371 0 show
29 Caption-Table 1 Identification of exons on the genome 0 37 0 show
30 Caption-Table 2 Genome-wide assessment of ab initio gene prediction methods 0 59 0 show
31 Caption-Table 3 Ontological classification of 22,339 human gene products 0 56 0 show
32 Caption-Table 4 (a) Density of features per megabase in Giemsa-staining cytogenetic bands 0 73 0 show