Dysmorphic phenotypes  Ratio in analyzed mice (affected/total)  Penetrance (%)
Head malformations  9/198  4.5
 cleft  4/198  2.0
 others  5/198  2.5
Edema (E12.5-E15.5)  15/155  9.7
Pale appearance (= E14.5)  72/72  100
Ocular lesions  28/198  14.1
 unilaterally absent eyes  21/198  10.6
  right  16/198  8.1
  left  5/198  2.5
 bilaterally absent eyes  7/198  3.5