Anxiety and sleep interruptions have become the norm of current stressful living (Han et al. 2012). Also, the instances of depression, suicidal attempts are soaring (Cash and Bridge 2009). Reliance on the prescription drugs is not free of side effects. The frequent intake aggregates the metabolic system in long term, becomes ineffective and overdose proves fatal. Opioid analgesics (buprenorphine, fentanyl, codeine, ativan, dextropropoxyphene, methadone, oxycodone, carisoprodol, etc.) overdose-caused death cases are rising dramatically (Paulozzi et al. 2012). The deadly combination opioid, benzodiazepines, and/or alcohol use poses huge risk of morbidity (Gudin et al. 2013). On the other hand, CAM are naturally sourced, thus pose lower genotoxicity compared to chemicals. In this regard, Z. nummularia root extract merits further investigation. Isolation of the functional constituents and their structural elucidation warrants impetus. In a preliminary screening study, the phytochemicals alkaloids (ziziphines), carbohydrates, saponins, flavonoids, anthocyanins, and tannins were found in the ethanolic extract of Z. oenoplia (Suksamrarn et al. 2005; Rao et al. 2012). These components might be instrumental in inducing the tested biological responses. The hypnotic efficacy of Z. jujuba Mill. jujubosides has been correlated to the impact on circadian rhythm and the serotonergic system (Cao et al. 2010). Further studies on the therapeutic importance of this plant might provide affordable medication to large section population in the developing countries. However, possible health risks must be verified for broader remedial applications.