The targets' information of main active components of QSYQ was obtained from two parts: pharmacophore virtual screening and the component-protein interaction database including ChEMBL (https://www.ebi.ac.uk/chembl/#) [11] and STITCH 3.1 (http://stitch.embl.de/) [12]. The 27 pharmacophore models which were applied to virtual screen were constructed by our laboratory team [13, 14]. ChEMBL is a manually curated chemical database which contains compound bioactivity data against drug targets. STITCH is a database in which every interaction has a confidence score, and the interactions with a confidence score > 0.7 were selected.