CD4+, CD8+ and NK cells can bind directly to cryptococci and act in a fungistatic fashion (Levitz et al., 1994). Cytotoxic CD4+ cells are able to release granulysin, like CD8+ T cells, to kill C. neoformans and are more effective at killing cryptococcal cells than CD8+ and NK cells in the blood (Zheng et al., 2007). CD4+ cells also play a role in CD8+ granulysin mediated cryptococcal degradation, whereby granulysin is up regulated and released dependent on CD4+ (Ma et al., 2002).