Eosinophils are granulocytes that primarily function by releasing cytotoxic granule proteins (Blanchard and Rothenberg, 2009; Feldmesser et al., 1997). However, although not professional phagocytes, eosinophils are capable of phagocytosis. In a rat cryptococcal model, eosinophils where shown to phagocytose cryptococci, become activated and produce a Th1 profile, indicating a role of activating the adaptive immune system, shown with an increase in MHC molecules (Garro et al., 2010). Furthermore, the interaction with cryptococci down regulated eosinophil NO and H2O2 production that may help to prolong eosinophil life, and therefore their efficacy during infection to act as an APC. Eosinophils activated by cryptococci were observed to migrate to the spleen and mesenteric lymph nodes and stimulate specific T cell and B cell proliferation (Garro et al., 2011). This suggests a positive role of eosinophils in the host response to cryptococcal infection in the rat.