C. neoformans is able to proliferate within the macrophage phagosome (Tucker and Casadevall, 2002; Voelz et al., 2009). This suggests that C. neoformans is able to inhabit the macrophage as a protective niche within the host. C. neoformans is also able to travel from one macrophage to another, whereby the receiving macrophage accepts the cryptococcal cell in an actin dependant manner (Alvarez and Casadevall, 2007; Ma et al., 2007). This is a rare event in vitro that has yet to be observed in vivo. The cause of this phenomenon, and if it benefits the host or the pathogen is unknown. The receiving cell may be assisting a potentially moribund macrophage or lateral transfer between macrophages allows evasion of extracellular host immune responses by cryptococci.