Acknowledgments We thank Dr. Jonathan Hodgkin and the Caenorhabditis Genome Center (funded by NIH Office of Research Infrastructure Programs; P40 OD010440) for strains. We thank Dr. Leon Avery for critically reading the manuscript and providing insightful suggestions. This work was supported by Inha University (J.K.) and the Virginia Commonwealth University School of Medicine (Y.Y.). Communicating editor: D. G. Moerman