Table 5  List of KEGG pathways for which at least two enzymes are differentially expressed at 25°
KEGG Pathways Upregulated at 25°   KEGG Pathways Downregulated at 25°
Pathway  # Enzymes  Pathway  # Enzymes
Purine metabolism  7  Purine metabolism  22
One carbon pool by folate  6  Phosphatidylinositol signaling system  11
Arginine and proline metabolism  5  Glycerophospholipid metabolism  10
Amino sugar and nucleotide sugar metabolism  5  Amino sugar and nucleotide sugar metabolism  9
Glycine, serine, and threonine metabolism  4  Inositol phosphate metabolism  9
Pyrimidine metabolism  4  Pyrimidine metabolism  8
Arachadonic acid metabolism  4  Pyruvate metabolism  8
Cysteine and methionine metabolism  4  Citrate cycle  7
Mucin type O-glycan biosynthesis  4  Pentose and glucuronate interconversions  7
Fructose and mannose metabolism  4  Fructose and mannose metabolism  7
Lysine degradation  3  Glycine, serine, and threonine metabolism  7
Aminoacyl-tRNA biosynthesis  3  Glutathione metabolism  7
Sphingolipid metabolism  3  Glycerolipid metabolism  7
Terpenoid backbone biosynthesis  3  Carbone fixation pathways in prokaryotes  7
Other types of O-glycan biosynthesis  3  Alanine, aspartate, and glutamate metabolism  6
Starch and sucrose metabolism  3  Tryptophan metabolism  6
Carbon fixation pathways in prokaryotes  3  Arachadonic acid metabolism  6
T-cell receptor signaling pathway  2  Porphyria and chlorophyll metabolism  6
Porphyrin and chlorophyll metabolism  2  Glycolysis/gluconeogenesis  5
Steroid biosynthesis  2  Pentose phosphate pathway  5
Glycosphingolipid biosynthesis—lacto and neglector series  2  Arginine and proline metabolism  5
Drug metabolism—other enzymes  2  Glycosylate and dicarboxylate metabolism  5
Alanine, aspartate and glutamate metabolism  2  Butanoate metabolism  5
Folate biosynthesis  2  Aminoacyl-tRNA biosynthesis  5
Linoleic acid metabolism  2  Galactose metabolism  4
Fatty acid degradation  4
Valine, leucine, and isoleucine degradation  4
Lysine degradation  4
Starch and sucrose metabolism  4
Glycosaminoglycan degradation  4
Ether lipid metabolism  4
Sphingolipid metabolism  4
Methane metabolism  4
Drug metabolism  4
Ascorbate and alderate metabolism  3
Synthesis and degradation of ketone bodies  3
Steroid hormone biosynthesis  3
Cysteine and methionine metabolism  3
Beta-alanine metabolism  3
Various types of N-glycan biosynthesis  3
Alpha-linolenic acid metabolism  3
Glycosphingolipid biosynthesis-globoseries  3
Propanoate metabolism  3
One carbon pool by foliate  3
Retinol metabolism in animals  3
Metabolism by xenobiotics by cytochrome P450  3
Drug metabolism—cytochrome P450  3
Geraniol degradation  2
Histidine metabolism  2
Tyrosine metabolism  2
Phenylalanine metabolism  2
Cyanoamino acid metabolism  2
N-glycan biosynthesis  2
Peptidoglycan biosynthesis  2
Linoleic acid metabolism  2
Chloroalkane and chloroalkene degradation  2
Aminobenzoate degradation  2
Carbone fixation in photosynthetic organisms  2
Nicotinate and nicotinamide metabolism  2
Nitrogen metabolism  2
Phenylpropanoid biosynthesis  2
mTOR signaling pathway  2
T-cell receptor signaling pathway  2
Several KEGG pathways are represented in both the upregulated and downregulated groups. For these common pathways, different enzymes are upregulated or downregulated.