Women were significantly more affected than men in shoulders, wrists/hands, upper back, lower back, and ankle/feet. Perceived physical and psychological demands were significantly associated with MSDs of different body regions. Pulling, pushing, moving, lifting and lowering heavy objects, working while bent or twisted at the waist, and repetitive motions with hands/wrists were the main physical factors retained in the regression models with odds ratios greater than 2. Conflicting demands, work is not remunerative, and no sufficient time to get the job done were the main psychological factors retained in the regression models with odds ratios greater than 1.68. Gender was found to be a significant factor for shoulders, wrists/hands, lower back, and ankles/feet with odds ratios ranging from 1.71 to 2.14. MSDs occurrence was more probable in the mentioned regions among women as compared to men. Both physical and psychological work demands in the work environment were contributing factors for developing MSDs among workers involved in weaving operations.