In the weaving industry, the weavers do the main job of weaving. Apart from weavers; majority of men, women, and children are involved in post- and pre-weaving operations. Weaving is one of the most tedious profession requiring long hours of static work.[4] In spite of national importance of weaving industry, and its impact on overall economy of the country, there have been few ergonomic studies of weavers work. Research has not focused on understanding the occupational risk factors in pre- and post-weaving operations. The present study was therefore conducted among workers involved in pre- and post-weaving operations. The main aim of the study was to elicit the role of physical and psychological work demands as risk factors for developing musculoskeletal symptoms in workers involved in weaving operations. The objectives of the study are to (i) determine the prevalence rate of musculoskeletal symptoms among workers involved in weaving operations, (ii) identify major factors associated with musculoskeletal symptoms in the study population, and (iii) examine the relationship between perceived physical and psychological work demands and musculoskeletal symptoms experienced in nine anatomical body regions viz., neck, shoulder, elbow, wrist/hand, upper back, lower back, hips/thighs, knees, and ankles/feet taking into consideration the impact of other potential confounding variables.