Table 2   Relationship between clinicopathological parameters and HIPK2 expression in human CRC
Variable   N   Nat different HIPK2 expression levels  χ 2   P
Low expression  High expression
−  +  ++  +++
Sex
Male  47  23  13  7  4  0.31  >0.05
Female  53  26  12  12  3
Age (years)
≤60  29  11  9  7  2  0.88  >0.05
>60  71  38  16  12  5
Maximum diameter of tumor
≤5  58  30  16  8  4  2.02  >0.05
>5  42  19  9  11  3
Degree of differentiation
Well differentiated  12  7  2  2  1  6.44  <0.05
Moderately differentiated  67  33  16  12  6
Poorly differentiated  5  1  4  0  0
Depth of invasion
Not invading serosa  42  28  7  5  2  4.71  >0.05
In serosa  25  6  9  9  1
Outside serosa  33  15  9  5  4
Duke stage
Stages A and B  72  35  19  15  3  0.13  >0.05
Stages C and D  28  14  6  4  4
Lymph node status
Metastasis  65  32  18  12  3  0.82  >0.05
No metastasis  35  17  7  7  4
TNM stage
Stages I and II  57  31  14  11  1  1.69  >0.05
Stages III and IV  43  18  11  8  6