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div. section text # proj. length # Ann.
0 TIAB Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors Summary Consti 4 964 0 show
1 Significance NF-κB has been implicated in many inflammatory and malignant diseases, such as MM. Yet therapeutical 4 829 0 show
2 Introduction In addition to orchestrating immune and inflammatory responses, NF-κB transcription factors play a c 4 4547 0 show
3 Results GADD45B Expression Denotes More Aggressive Disease in MM Given their key role in oncogenesis, we sou 4 1888 0 show
4 Results Constitutive NF-κB Activity Promotes the Survival of MM Cells by Inhibiting JNK Signaling GADD45β in 4 1881 0 show
5 Results GADD45β as a Pivotal Survival Factor Downstream of NF-κB and a Potential Therapeutic Target in MM To 4 2200 0 show
6 Results Development of D-Tetrapeptide Inhibitors of the GADD45β/MKK7 Complex Given the essential antiapoptot 4 4261 0 show
7 Results The Development of DTP3: A GADD45β/MKK7 Inhibitor with Improved Bioavailability To improve the bioav 4 2349 0 show
8 Results The High Target Specificity of DTP3 for the GADD45β/MKK7 Complex In a panel of tumor cell lines of d 4 2955 0 show
9 Results The Potent and Cancer-Selective Activity of DTP3 in MM Cells from Patients To verify the suitability 4 2711 0 show
10 Results The Potent Therapeutic Efficacy and Excellent Tolerability of DTP3 against MM In Vivo DTP3 showed hi 4 2655 0 show
11 Discussion We identified the GADD45β/MKK7 complex as a functionally critical survival module downstream of NF-κ 4 5321 0 show
12 Experimental Procedures Cell Purification and Culture Cells were cultured according to standard protocols (Mauro et al., 201 4 873 0 show
13 Experimental Procedures Biochemical Assays Quantitative RT-PCR (qRT-PCR) assays were carried out using the TaqMan Gene Expre 4 424 0 show
14 Experimental Procedures Cellular Assays Lentiviral infections were performed using pLentiLox.3.7, as described by Mauro et a 4 669 0 show
15 Experimental Procedures Peptide Synthesis and ELISA Proteins were purified as described by Tornatore et al. (2008). The comb 4 685 0 show
16 Experimental Procedures DTP3 Binding Assays The stoichiometry and KD value of the DTP3/MKK7 interaction were determined by t 4 466 0 show
17 Experimental Procedures Pharmacophore Analyses and Modeling See Supplemental Experimental Procedures. 4 77 0 show
18 Experimental Procedures Pharmacokinetic Analyses The pharmacokinetic analyses of DTP3 and z-DTP2 were outsourced. Additional 4 162 0 show
19 Experimental Procedures Animal Studies Mice were housed in the animal facilities at Hammersmith. All experiments were conduc 4 1052 0 show
20 Experimental Procedures Statistical Analyses See Supplemental Experimental Procedures. 4 62 0 show