(B) Western blot showing effective knock-down of IGF2 in CGNPs infected with either GFP or YAP, then transduced with lentiviruses targeting IGF2 for short hairpin RNA-mediated knock-down or encoding for a scrambled shRNA sequence. IGF2 knockdown reduces Akt phosphorylation and rescues ATM and Chk2 phosphorylation in YAP-transduced cells 3 hours after irradiation.