10.1371/journal.pone.0041912.g001 Figure 1  Structure of the Sema-PSI domains of human RON receptor tyrosine kinase.
(A) Ribbon representation of RON Sema-PSI, viewed down the β-propeller, with the color ramped from blue at the N-terminus to red at the C-terminus. The blades are numbered and the antiparallel β-strands of each blade are labeled A–D from the inner to the outermost strands. Disulfide bonds are shown in red and the N-linked oligosaccharide is shown as stick models with the atomic color scheme: Green – carbon, red – oxygen, blue – nitrogen. (B) Surface rendering of the top and bottom surfaces of RON Sema-PSI, represented by electrostatistic potential from red (−10 kbT/ec) to blue (10 kbT/ec), as generated by PyMol. The left panel represents the top surface using the same orientation as in (A). The right panel corresponds to the opposite or bottom β-propeller surface.