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Conclusions
We show for the first time that adiponectin increases the level of VEGF and MMPs in RA FLSs as much as IL-1β but causes much smaller increases in IL-6, IL-8, and COX-2 compared with IL-1β. Furthermore, the level of adiponectin in the joint fluid of RA patients, but not OA patients, positively correlated with the level of VEGF. Although these data suggest a role for adiponectin in the perpetuation of synovitis in RA, no conclusions can be drawn from these results with regard to the relationship between adiponectin and inflammatory arthritis. Additional mechanistic and longitudinal studies in humans in the future might help to correlate our findings with clinical features.

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