Epinephrine
Epinephrine is a direct acting sympathomimetic amine. Epinephrine stimulates both a and β-adrenoreceptors within the eye. It reduces IOP by increasing the aqueous humor outflow through the trabecular meshwork and uveoscleral pathway. However, recent studies have shown that topical epinephrine did not significantly affect the uveoscleral outflow or the episcleral venous pressure.[13–15] Reduction in IOP ranges from 15-25% for epinephrine, but is accompanied by adverse effects including blurred vision, headache, palpitations, high blood pressure, and anxiety.