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PMC:2195754 JSONTXT

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div. section text # proj. length # Ann.
0 TIAB Clonal Deleterious Mutations in the Iκbα Gene in the Malignant Cells in Hodgkin's Lymphoma Members o 2 1269 263 show
1 Introduction Hodgkin's lymphoma (HL) is the most common type of malignant lymphoma in the Western world. It is di 2 5770 0 show
2 Materials and Methods Analysis of HL-derived Cell Lines. IκBα protein was detected by Western blot with an antibody direct 2 527 0 show
3 Materials and Methods Primary Cases. The primary cases were as follows: 1 mandibular lymph node biopsy from a 12-yr-old fe 2 605 0 show
4 Materials and Methods Analysis of Primary Cases. Total genomic DNA was isolated from sections of the lymph nodes using the 2 3367 0 show
5 Materials and Methods Analysis of Normal B Cell Populations. Tonsillar mononuclear cells were sequentially incubated with 2 1020 0 show
6 Materials and Methods Analysis of Non-HLs. The six IκBα exons were amplified as above from DNA of peripheral blood lymphoc 2 908 0 show
7 Results and Discussion A panel of eight HL-derived cell lines was screened for IκBα defects by Western blot, reverse transc 2 10989 0 show
8 Caption-Figure 1 IκBα defects in HL. The structure of the IκBα gene (top; the amplified regions spanning exons 1–6 ar 2 402 0 show
9 Caption-Table 1 Analysis of the IκBα Protein, Transcripts, and Gene in HL-derived Cell Lines 2 76 0 show
10 Caption-Table 2 Sequence Analysis of the IκBα Exons Amplified from Tissue Sections and Single H/RS Cells 2 88 0 show
11 Caption-Table 3 Analysis of IκBα Exons 1 and 4 Amplified from Aliquots of Genomic DNA from Single H/RS Cells of Case 2 102 0 show
12 Caption-Table 4 Analysis of IκBα Exons 1 and 2 in Normal B Cells 2 48 0 show