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div. section text # proj. length # Ann.
0 TIAB Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis Bone mor 5 1514 911 show
1 Introduction Bone morphogenetic proteins (BMPs) are secreted signaling molecules belonging to the transforming gr 5 8477 2317 show
2 Results To investigate the roles of BMP signaling at various stages of limb patterning and skeletogenesis, w 5 1919 1278 show
3 Results An Allelic/Nonallelic Series of BMP-Deficient Limbs Mice were generated with limbs deficient in BMP2 5 4077 2647 show
4 Results Soft Tissue Syndactyly Observed in Limbs of Mice Devoid of BMP2 and BMP4 Activity As noted above, Bm 5 2556 1749 show
5 Results Patterning Defects in Limb Developing with Reduced Levels of BMP Signaling BMP signaling has been pr 5 6155 3807 show
6 Results Skeletal Differentiation in Limbs Developing with Reduced Levels of BMP Signaling BMPs were first di 5 1401 792 show
7 Results BMP2 and BMP4 Are Not Critical for Chondrogenic Differentiation As noted above, at E12.5, chondrogen 5 1892 1193 show
8 Results Osteogenesis Is Initiated Normally in BMP2, BMP4–Deficient Limb Buds Bone formation first occurs at 5 4837 3167 show
9 Discussion Using a genetic approach to remove activity of differentBmpgenes during limb development, we have fo 5 585 357 show
10 Discussion BMP Signaling and Pattern Formation It has been proposed that BMP signaling may be involved in digit 5 6177 3645 show
11 Discussion BMP Signaling and Skeletal Development As discussed above, our data indicate that threshold levels o 5 4663 2982 show
12 Materials and Methods Reagents. Xylene, formamide, and acetic anhydride were purchased from Fisher Scientific (http://www. 5 456 232 show
13 Materials and Methods Generation of Bmp2 and Bmp4 conditional null allele. Mice carrying floxed Bmp2 allele were available 5 420 274 show
14 Materials and Methods Generation of Bmp2, Bmp4 double conditional mice and Bmp2 conditional, Bmp7 mutant mice. Bmp2C/C ani 5 2767 2106 show
15 Materials and Methods Skeletal analysis. Our protocol is an adaptation of the procedure described [56] previously. Newborn 5 878 576 show
16 Materials and Methods Acridine orange staining for apoptotic cells. A working stock of 5 mg/ml acridine orange was diluted 5 339 216 show
17 Materials and Methods Whole mount in situ hybridization. In situ hybridization staining on whole embryos was performed as 5 169 106 show
18 Materials and Methods Histology, section in situ hybridizations, and immunohistochemistry. For histology and section in si 5 2721 1733 show