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Cis-eQTLs Are Candidate Genes for the Gonadal Fat Mass Trait
Given the marked effects of sex on liver gene expression and the genetic regulation of gonadal fat mass, we reasoned that cis-eQTLs with significant “sex-additive” and “sex-dominant” interactions would be potential candidate genes for our trait. Of the 2,118 significant cis-eQTLs, 304 (14%) were improved by the sex-interaction terms. Cis-eQTLs overlapping the confidence interval for the fat mass cQTL are candidate genes for the trait. Those genes with significant sex interactions receive increased consideration as potential candidates (Tables 4 and 5).

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