|Cis-eQTLs Are Candidate Genes for the Gonadal Fat Mass Trait|
Given the marked effects of sex on liver gene expression and the genetic regulation of gonadal fat mass, we reasoned that cis-eQTLs with significant “sex-additive” and “sex-dominant” interactions would be potential candidate genes for our trait. Of the 2,118 significant cis-eQTLs, 304 (14%) were improved by the sex-interaction terms. Cis-eQTLs overlapping the confidence interval for the fat mass cQTL are candidate genes for the trait. Those genes with significant sex interactions receive increased consideration as potential candidates (Tables 4 and 5).