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PMC:1208873 JSONTXT

Divisions (15) JSON TSV

div. section text # proj. length # Ann.
0 TIAB Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patt 5 2109 1165 show
1 Background Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder that is caused by CAG 5 4050 2329 show
2 Results Huntingtin-deficient embryos exhibit abnormal streak progression and paraxial mesoderm production Si 5 5410 4060 show
3 Results Impaired regional restriction of growth factor expression in the absence of huntingtin To elucidate 5 3191 2522 show
4 Results Huntingtin is not required for expression of extraembryonic signaling molecules Previous studies of 5 4421 3527 show
5 Discussion We have investigated the embryonic processes that require huntingtin in order to more precisely deli 5 6716 3908 show
6 Conclusion Our findings indicate that huntingtin is required for proper patterning of the epiblast during early 5 820 429 show
7 Methods Mice and genotyping The Hdhex4/5 mice carrying a pGKneo insertion/replacement inactivating mutation 5 771 491 show
8 Methods Whole mount and section in situ hybridization and β-gal staining After dissection in PBS, embryos we 5 741 456 show
9 Methods Alkaline phosphatase staining of Primordial Germ Cells (PCGs) After dissections, embryos were fixed 5 504 386 show
10 Methods Whole embryo culture Embryos were dissected at E7.5 and washed in DMEM. Embryos were then cultured i 5 314 209 show
11 Caption-Figure 1 AVE displacement and anterior neurectoderm induction occur normally in the absence of huntingtin. Wh 5 948 626 show
12 Caption-Figure 2 Huntingtin is required for formation of anterior primitive streak and paraxial mesoderm. Whole mount 5 1289 975 show
13 Caption-Figure 3 Impaired regional restriction of gene expression in huntingtin deficient embryos. X-gal staining of 5 1186 841 show
14 Caption-Figure 4 Normal expression of extraembryonic markers in huntingtin deficient embryos. Whole mount in situ hyb 5 1934 1348 show