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div. section text # proj. length # Ann.
0 TIAB PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal We 6 1645 1580 show
1 Introduction Mitochondrial functional capacity is dynamically regulated to meet the diverse energy demands impose 6 4316 4633 show
2 Results Disruption of the PGC-1α Gene in Mice A neomycin-based gene targeting vector was generated to delete 6 2209 2704 show
3 Results General Characteristics of the PGC-1α−/− Mice: Age- and Sex-Dependent Obesity Heterozygous (PGC-1α+/ 6 2460 2995 show
4 Results Abnormal Muscle Mitochondrial Phenotype in PGC-1α−/− Mice General histologic analyses were performed 6 2381 2823 show
5 Results Altered Skeletal Muscle Function in PGC-1α−/− Mice The abnormality in mitochondrial number and respi 6 3744 4392 show
6 Results Functional Abnormalities in Hearts of PGC-1α−/− Mice PGC-1α expression is enriched in heart, a tissu 6 3247 3645 show
7 Results PGC-1α−/− Mice Exhibit an Abnormal Thermogenic Response PGC-1α has been implicated as an inducible r 6 2636 3028 show
8 Results Fasting-Induced Hepatic Steatosis in PGC-1α−/− Mice Previous studies have implicated PGC-1α in sever 6 3980 4424 show
9 Results Despite a Mild Obese Phenotype, Female PGC-1α−/− Mice Do Not Exhibit Insulin Resistance Recent studi 6 1842 2658 show
10 Results Structural Abnormalities of the Central Nervous System in PGC-1α−/− Mice In surveying the tissues of 6 2046 2141 show
11 Discussion Previous studies using gain-of-function strategies have shown that the coactivator PGC-1α is capable 6 14208 13483 show
12 Materials and Methods Targeting the PGC-1α gene in mice A BAC genomic clone containing the murine PGC-1α gene, isolated fr 6 1642 1765 show
13 Materials and Methods General animal studies All animal experiments and euthanasia protocols were conducted in strict acco 6 1824 2013 show
14 Materials and Methods RNA, DNA, and protein analyses Total RNA was isolated by the RNAzol method (Tel-Test, Friendswood, T 6 1661 1916 show
15 Materials and Methods Mitochondrial respiration studies Mitochondrial respiration was assessed in saponin-skinned soleus f 6 1439 1958 show
16 Materials and Methods Insulin and glucose tolerance tests Glucose and Insulin tolerance tests were performed as described 6 541 769 show
17 Materials and Methods Indirect calorimetry Oxygen consumption rates (VO2) of 5-wk-old female mice were measured using a Co 6 473 508 show
18 Materials and Methods Histology and electron microscopy Soleus muscle and liver were dissected and fixed overnight in 2% g 6 1140 1189 show
19 Materials and Methods Primary mouse hepatocyte studies Primary cultures of mouse hepatocytes were prepared from male PGC-1 6 811 966 show
20 Materials and Methods Evaluation of locomotor activity, sensorimotor capabilities, and muscle function To evaluate general 6 3267 3904 show
21 Materials and Methods VO2max studies VO2max was determined while the mice were running on a treadmill using an open flow s 6 805 921 show
22 Materials and Methods Isolated muscle stimulation studies Animals were anesthetized with ketamine/xylazine and the soleus 6 1165 1238 show
23 Materials and Methods Exercise echocardiography Adult female mice (6–8 mo old) were exercised on the motorized treadmill u 6 383 377 show
24 Materials and Methods In vivo cardiac hemodynamic studies Hemodynamic studies were performed as previously described with 6 937 941 show
25 Materials and Methods Isolated working mouse heart perfusion Isolated working mouse heart perfusion was based on a previou 6 1336 1557 show
26 Materials and Methods Statistics Data were analyzed using T-tests or ANOVAs (measures of general activity and sensorimotor 6 834 920 show