OMIM_backup@xiajingbo:106180-2-ACE JSONTXT

Factors involved in the pathogenesis of atherosclerosis, thrombosis, and vasoconstriction contribute to the development of coronary heart disease. In a study comparing patients after myocardial infarction (MI) with controls, Cambien et al. (1992) found association between coronary heart disease and the ACE/ID polymorphism. They determined that the frequency of the ACE/DD genotype in the 'general population' is approximately 0.27. The ACE polymorphism was unrelated to blood pressure and hypertension. Cambien et al. (1992) estimated that in the low-risk group, i.e., those without tobacco usage, high blood pressure, diabetes, obesity, or hypercholesterolemia, the ACE/DD genotype may account for 35% of cases of myocardial infarction. The results of these studies correlate with those of Pfeffer et al. (1992), which showed that administration of an ACE inhibitor not only decreased the risk of developing heart failure but also reduced the risk for recurrent myocardial infarction. Experimental studies had shown that ACE gene expression is increased in myocardial tissue after coronary artery occlusion.