NR3C2@yaoxinzhi:600983 JSONTXT

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Structural and biochemical studies indicated that S810L results in the gain of a van der Waals interaction between helix 5 and helix 3 that substitutes for interaction of the steroid 21-hydroxyl group with helix 3 in the wildtype receptor. This helix 5-helix 3 interaction is highly conserved among diverse nuclear hormone receptors, suggesting its general role in receptor activation. The effect of the S810L mutation was to invert the mineralocorticoid receptor from aldosterone-responsive to progesterone-responsive, with development of hypertension during pregnancy. This was the first mendelian form of preeclampsia to be identified. 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