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    FA_Top107-forWeb

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Dixon, Lewis M. Brown, Carlos A. Valenzuela, Adam J. Wolpaw, Brent R. Stockwell\r\nNature Chemical Biology, DOI: 10.1038/nchembio.2079\r\n\r\n\u3008\u8981 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Committee of Cell 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medicine\uff09\u306e\u5b9f\u73fe\u304c\u6025\u901f\u306b\u9032\u3081\u3089\u308c\u3066\u3044\u308b\u304c\uff0c\u500b\u3005\u306e\u304c\u3093\u7d30\u80de\u306b\u52b9\u679c\u7684\u306a\u6297\u304c\u3093\u5264\u3092\u307f\u3064\u3051\u3060\u3059\u305f\u3081\u306b\u306f\uff0c\u304c\u3093\u306e\u539f\u56e0\u3068\u306a\u308b\u30c9\u30e9\u30a4\u30d0\u30fc\u5909\u7570\u306e\u89e3\u6790\u3060\u3051\u3067\u306f\u306a\u304f\uff0c\u7570\u306a\u308b\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u6297\u304c\u3093\u5264\u306e\u958b\u767a\u304c\u91cd\u8981\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u308b\uff0e\u304a\u306e\u304a\u306e\u306e\u7d30\u80de\u6b7b\u306e\u8868\u73fe\u578b\u306f\uff0c\u591a\u5c11\u306e\u91cd\u8907\u306f\u8a8d\u3081\u3089\u308c\u308b\u3068\u3057\u3066\u3082\uff0c\u7570\u306a\u308b\u6a5f\u69cb\u306b\u3088\u308a\u5236\u5fa1\u3055\u308c\u308b\u305f\u3081\u3067\u3042\u308b\uff0e\u30b2\u30ce\u30e0\u306e\u4e0d\u5b89\u5b9a\u306a\u304c\u3093\u306f1\u7a2e\u985e\u306e\u6297\u304c\u3093\u5264\u306b\u5bfe\u3057\u3066\u306f\u5bb9\u6613\u306b\u8010\u6027\u3092\u7372\u5f97\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u305d\u306e\u70b9\uff0c\u7570\u306a\u308b\u6a5f\u69cb\u306b\u3088\u308a\u5236\u5fa1\u3055\u308c\u308b\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u6297\u304c\u3093\u5264\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u308a\uff0c\u305d\u306e\u3059\u3079\u3066\u306b\u5bfe\u3057\u8010\u6027\u3092\u7372\u5f97\u3059\u308b\u307e\u3048\u306b\u304c\u3093\u7d30\u80de\u3092\u6b7b\u6ec5\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u98db\u8e8d\u7684\u306b\u3042\u304c\u308b\u3068\u8003\u3048\u3089\u308c\u308b\uff0e\r\n\r\n\u3008\u6587 \u732e\u3009\r\n 1) Vanden Berghe, T., Linkermann, A., Jouan-Lanhouet, S. et al.: Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat. Rev. Mol. Cell Biol., 15, 135-147 (2014)\r\n 2) Dixon, S. J., Lemberg, K. M., Lamprecht, M. R. et al.: Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell, 149, 1060-1072 (2012)\r\n 3) Yang, W. S., SriRamaratnam, R., Welsch, M. E. et al.: Regulation of ferroptotic cancer cell death by GPX4. Cell, 156, 317-331 (2014)\r\n 4) Dixon, S. J., Patel, D. N., Welsch, M. et al.: Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife, 3, e02523 (2014)\r\n 5) Linkermann, A., Skouta, R., Himmerkus, N. et al.: Synchronized renal tubular cell death involves ferroptosis. Proc. Natl. Acad. Sci. USA, 111, 16836-16841 (2014)\r\n 6) Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I. et al.: Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ., 22, 58-73 (2015)\r\n 7) Wolpaw, A. J., Shimada, K., Skouta, R. et al.: Modulatory profiling identifies mechanisms of small molecule-induced cell death. Proc. Natl. Acad. Sci. USA, 108, E771-E780 (2011)\r\n 8) Hahn, W. C., Counter, C. M., Lundberg, A. S. et al.: Creation of human tumour cells with defined genetic elements. Nature, 400, 464-468 (1999)\r\n 9) Tansey, T. R. \u0026 Shechter, I.: Structure and regulation of mammalian squalene synthase. Biochim. Biophys. Acta, 1529, 49-62 (2000)\r\n10) Yagoda, N., von Rechenberg, M., Zaganjor, E. et al.: RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature, 447, 865-869 (2007)\r\n11) Hirsch, H. A., Iliopoulos, D., Joshi, A. et al.: A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell, 17, 348-361 (2010)\r\n\r\n\u3008\u8457\u8005\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u3009\r\n\u5d8b\u7530 \u5065\u4e00\uff08Kenichi Shimada\uff09\r\n\u7565\u6b74\uff1a2015\u5e74 \u7c73\u56fdColumbia\u5927\u5b66\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b \u4fee\u4e86\uff0c\u540c\u5e74\u3088\u308a\u7c73\u56fdHarvard Medical School\u30dd\u30b9\u30c8\u30c9\u30af\u30c8\u30e9\u30eb\u30d5\u30a7\u30ed\u30fc\uff0e\r\n\u7814\u7a76\u30c6\u30fc\u30de\uff1a\u85ac\u7269\u306b\u3088\u308b\u809d\u81d3\u306e\u969c\u5bb3\u306b\u304a\u3051\u308b\u7d30\u80de\u9593\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u306f\u305f\u3059\u5f79\u5272\uff0e\r\n\u62b1\u8ca0\uff1a\u30b7\u30b9\u30c6\u30e0\u751f\u7269\u5b66\u3092\u7528\u3044\u3066\u8907\u96d1\u306a\u751f\u547d\u73fe\u8c61\u3092\u89e3\u660e\u3057\u305f\u3044\uff0e\r\n\r\n\u3008\u56f3\u8aac\u660e\u3009\r\n\u56f31\u3000\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u6cd5\u306e\u539f\u7406\r\n\uff08a\uff09\u7d30\u80de\u6b7b\u3092\u3072\u304d\u8d77\u3053\u3059\u3088\u3046\u306a\u4f4e\u5206\u5b50\u5316\u5408\u7269\uff0c\u304a\u3088\u3073\uff0c\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u306e\u3082\u3068\uff0c\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306e\u7d30\u80de\u306b\u5bfe\u3059\u308b\u52b9\u529b\u304c\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3059\u308b\u304b\u8abf\u3079\u308b\uff0e\r\n\uff08b\uff09\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u6b7b\u3092\u3072\u304d\u8d77\u3053\u3059\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306f\uff0c\u304a\u306e\u304a\u306e\u306e\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u306e\u3082\u3068\u3067\u306e\u7d30\u80de\u306b\u5bfe\u3059\u308b\u52b9\u529b\u306e\u5206\u6563\u304c\u5927\u304d\u3044\uff0e\r\n\u56f32\u3000FIN56\u306e\u4f5c\u7528\u6a5f\u5e8f\u306e\u30e2\u30c7\u30eb\r\n"}

    FA_Top100Plus-GeneProtein

    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Dixon, Lewis M. Brown, Carlos A. Valenzuela, Adam J. Wolpaw, Brent R. Stockwell\r\nNature Chemical Biology, DOI: 10.1038/nchembio.2079\r\n\r\n\u3008\u8981 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Committee of Cell 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medicine\uff09\u306e\u5b9f\u73fe\u304c\u6025\u901f\u306b\u9032\u3081\u3089\u308c\u3066\u3044\u308b\u304c\uff0c\u500b\u3005\u306e\u304c\u3093\u7d30\u80de\u306b\u52b9\u679c\u7684\u306a\u6297\u304c\u3093\u5264\u3092\u307f\u3064\u3051\u3060\u3059\u305f\u3081\u306b\u306f\uff0c\u304c\u3093\u306e\u539f\u56e0\u3068\u306a\u308b\u30c9\u30e9\u30a4\u30d0\u30fc\u5909\u7570\u306e\u89e3\u6790\u3060\u3051\u3067\u306f\u306a\u304f\uff0c\u7570\u306a\u308b\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u6297\u304c\u3093\u5264\u306e\u958b\u767a\u304c\u91cd\u8981\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u308b\uff0e\u304a\u306e\u304a\u306e\u306e\u7d30\u80de\u6b7b\u306e\u8868\u73fe\u578b\u306f\uff0c\u591a\u5c11\u306e\u91cd\u8907\u306f\u8a8d\u3081\u3089\u308c\u308b\u3068\u3057\u3066\u3082\uff0c\u7570\u306a\u308b\u6a5f\u69cb\u306b\u3088\u308a\u5236\u5fa1\u3055\u308c\u308b\u305f\u3081\u3067\u3042\u308b\uff0e\u30b2\u30ce\u30e0\u306e\u4e0d\u5b89\u5b9a\u306a\u304c\u3093\u306f1\u7a2e\u985e\u306e\u6297\u304c\u3093\u5264\u306b\u5bfe\u3057\u3066\u306f\u5bb9\u6613\u306b\u8010\u6027\u3092\u7372\u5f97\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\uff0e\u305d\u306e\u70b9\uff0c\u7570\u306a\u308b\u6a5f\u69cb\u306b\u3088\u308a\u5236\u5fa1\u3055\u308c\u308b\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3059\u308b\u6297\u304c\u3093\u5264\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u308a\uff0c\u305d\u306e\u3059\u3079\u3066\u306b\u5bfe\u3057\u8010\u6027\u3092\u7372\u5f97\u3059\u308b\u307e\u3048\u306b\u304c\u3093\u7d30\u80de\u3092\u6b7b\u6ec5\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u98db\u8e8d\u7684\u306b\u3042\u304c\u308b\u3068\u8003\u3048\u3089\u308c\u308b\uff0e\r\n\r\n\u3008\u6587 \u732e\u3009\r\n 1) Vanden Berghe, T., Linkermann, A., Jouan-Lanhouet, S. et al.: Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat. Rev. Mol. Cell Biol., 15, 135-147 (2014)\r\n 2) Dixon, S. J., Lemberg, K. M., Lamprecht, M. R. et al.: Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell, 149, 1060-1072 (2012)\r\n 3) Yang, W. S., SriRamaratnam, R., Welsch, M. E. et al.: Regulation of ferroptotic cancer cell death by GPX4. Cell, 156, 317-331 (2014)\r\n 4) Dixon, S. J., Patel, D. N., Welsch, M. et al.: Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife, 3, e02523 (2014)\r\n 5) Linkermann, A., Skouta, R., Himmerkus, N. et al.: Synchronized renal tubular cell death involves ferroptosis. Proc. Natl. Acad. Sci. USA, 111, 16836-16841 (2014)\r\n 6) Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I. et al.: Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ., 22, 58-73 (2015)\r\n 7) Wolpaw, A. J., Shimada, K., Skouta, R. et al.: Modulatory profiling identifies mechanisms of small molecule-induced cell death. Proc. Natl. Acad. Sci. USA, 108, E771-E780 (2011)\r\n 8) Hahn, W. C., Counter, C. M., Lundberg, A. S. et al.: Creation of human tumour cells with defined genetic elements. Nature, 400, 464-468 (1999)\r\n 9) Tansey, T. R. \u0026 Shechter, I.: Structure and regulation of mammalian squalene synthase. Biochim. Biophys. Acta, 1529, 49-62 (2000)\r\n10) Yagoda, N., von Rechenberg, M., Zaganjor, E. et al.: RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature, 447, 865-869 (2007)\r\n11) Hirsch, H. A., Iliopoulos, D., Joshi, A. et al.: A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell, 17, 348-361 (2010)\r\n\r\n\u3008\u8457\u8005\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u3009\r\n\u5d8b\u7530 \u5065\u4e00\uff08Kenichi Shimada\uff09\r\n\u7565\u6b74\uff1a2015\u5e74 \u7c73\u56fdColumbia\u5927\u5b66\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b \u4fee\u4e86\uff0c\u540c\u5e74\u3088\u308a\u7c73\u56fdHarvard Medical School\u30dd\u30b9\u30c8\u30c9\u30af\u30c8\u30e9\u30eb\u30d5\u30a7\u30ed\u30fc\uff0e\r\n\u7814\u7a76\u30c6\u30fc\u30de\uff1a\u85ac\u7269\u306b\u3088\u308b\u809d\u81d3\u306e\u969c\u5bb3\u306b\u304a\u3051\u308b\u7d30\u80de\u9593\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u306f\u305f\u3059\u5f79\u5272\uff0e\r\n\u62b1\u8ca0\uff1a\u30b7\u30b9\u30c6\u30e0\u751f\u7269\u5b66\u3092\u7528\u3044\u3066\u8907\u96d1\u306a\u751f\u547d\u73fe\u8c61\u3092\u89e3\u660e\u3057\u305f\u3044\uff0e\r\n\r\n\u3008\u56f3\u8aac\u660e\u3009\r\n\u56f31\u3000\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u6cd5\u306e\u539f\u7406\r\n\uff08a\uff09\u7d30\u80de\u6b7b\u3092\u3072\u304d\u8d77\u3053\u3059\u3088\u3046\u306a\u4f4e\u5206\u5b50\u5316\u5408\u7269\uff0c\u304a\u3088\u3073\uff0c\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u306e\u3082\u3068\uff0c\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306e\u7d30\u80de\u306b\u5bfe\u3059\u308b\u52b9\u529b\u304c\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3059\u308b\u304b\u8abf\u3079\u308b\uff0e\r\n\uff08b\uff09\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u6b7b\u3092\u3072\u304d\u8d77\u3053\u3059\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306f\uff0c\u304a\u306e\u304a\u306e\u306e\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u306e\u3082\u3068\u3067\u306e\u7d30\u80de\u306b\u5bfe\u3059\u308b\u52b9\u529b\u306e\u5206\u6563\u304c\u5927\u304d\u3044\uff0e\r\n\u56f32\u3000FIN56\u306e\u4f5c\u7528\u6a5f\u5e8f\u306e\u30e2\u30c7\u30eb\r\n"}

    FA_Top100-Disease

    {"project":"FA_Top100-Disease","denotations":[{"id":"FirstAuthorDictionay_T2","span":{"begin":1025,"end":1027},"obj":"something"},{"id":"FirstAuthorDictionay_T4","span":{"begin":1086,"end":1088},"obj":"something"},{"id":"FirstAuthorDictionay_T8","span":{"begin":1354,"end":1356},"obj":"something"},{"id":"T1","span":{"begin":1515,"end":1524},"obj":"http://purl.obolibrary.org/obo/MONDO_0015742"},{"id":"FirstAuthorDictionay_T10","span":{"begin":1525,"end":1532},"obj":"http://purl.obolibrary.org/obo/MONDO_0007739"},{"id":"T2","span":{"begin":1533,"end":1540},"obj":"http://purl.obolibrary.org/obo/MONDO_0006637"},{"id":"FirstAuthorDictionay_T15","span":{"begin":5651,"end":5653},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T17","span":{"begin":5775,"end":5777},"obj":"http://purl.obolibrary.org/obo/HP_0002664"},{"id":"FirstAuthorDictionay_T19","span":{"begin":5803,"end":5805},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T21","span":{"begin":6022,"end":6024},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T23","span":{"begin":6046,"end":6048},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T25","span":{"begin":6164,"end":6166},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"},{"id":"FirstAuthorDictionay_T28","span":{"begin":6258,"end":6260},"obj":"http://purl.obolibrary.org/obo/MONDO_0004992"}],"text":"\u3008\u30bf\u30a4\u30c8\u30eb\u3009\u5236\u5fa1\u3055\u308c\u305f\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u3092\u3072\u304d\u8d77\u3053\u3059\u65b0\u898f\u306e\u4f4e\u5206\u5b50\u5316\u5408\u7269FIN56\u306f\u8102\u8cea\u306e\u5408\u6210\u3092\u6a19\u7684\u306b\u3059\u308b\r\n\r\n\u3008\u8457 \u8005\u3009\u5d8b\u7530 \u5065\u4e00\r\n\u3008\u8457\u8005\u6240\u5c5e\u3009\u7c73\u56fdColumbia\u5927\u5b66Department of Biological Sciences\r\n\u3008\u8457\u8005email\u3009kenichi.shimada@gmail.com\uff08\u5d8b\u7530\u5065\u4e00\uff09\r\n\r\n\u3008\u5bfe\u8c61\u8ad6\u6587\u3009\r\nGlobal survey of cell death mechanisms reveals metabolic regulation of ferroptosis.\r\nKenichi Shimada, Rachid Skouta, Anna Kaplan, Wan Seok Yang, Miki Hayano, Scott J. Dixon, Lewis M. Brown, Carlos A. Valenzuela, Adam J. Wolpaw, Brent R. Stockwell\r\nNature Chemical Biology, DOI: 10.1038/nchembio.2079\r\n\r\n\u3008\u8981 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Committee of Cell 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Cancer Cell, 17, 348-361 (2010)\r\n\r\n\u3008\u8457\u8005\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u3009\r\n\u5d8b\u7530 \u5065\u4e00\uff08Kenichi Shimada\uff09\r\n\u7565\u6b74\uff1a2015\u5e74 \u7c73\u56fdColumbia\u5927\u5b66\u5927\u5b66\u9662\u535a\u58eb\u8ab2\u7a0b \u4fee\u4e86\uff0c\u540c\u5e74\u3088\u308a\u7c73\u56fdHarvard Medical School\u30dd\u30b9\u30c8\u30c9\u30af\u30c8\u30e9\u30eb\u30d5\u30a7\u30ed\u30fc\uff0e\r\n\u7814\u7a76\u30c6\u30fc\u30de\uff1a\u85ac\u7269\u306b\u3088\u308b\u809d\u81d3\u306e\u969c\u5bb3\u306b\u304a\u3051\u308b\u7d30\u80de\u9593\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306e\u306f\u305f\u3059\u5f79\u5272\uff0e\r\n\u62b1\u8ca0\uff1a\u30b7\u30b9\u30c6\u30e0\u751f\u7269\u5b66\u3092\u7528\u3044\u3066\u8907\u96d1\u306a\u751f\u547d\u73fe\u8c61\u3092\u89e3\u660e\u3057\u305f\u3044\uff0e\r\n\r\n\u3008\u56f3\u8aac\u660e\u3009\r\n\u56f31\u3000\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u6cd5\u306e\u539f\u7406\r\n\uff08a\uff09\u7d30\u80de\u6b7b\u3092\u3072\u304d\u8d77\u3053\u3059\u3088\u3046\u306a\u4f4e\u5206\u5b50\u5316\u5408\u7269\uff0c\u304a\u3088\u3073\uff0c\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u306e\u3082\u3068\uff0c\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306e\u7d30\u80de\u306b\u5bfe\u3059\u308b\u52b9\u529b\u304c\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3059\u308b\u304b\u8abf\u3079\u308b\uff0e\r\n\uff08b\uff09\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u6b7b\u3092\u3072\u304d\u8d77\u3053\u3059\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306f\uff0c\u304a\u306e\u304a\u306e\u306e\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u306e\u3082\u3068\u3067\u306e\u7d30\u80de\u306b\u5bfe\u3059\u308b\u52b9\u529b\u306e\u5206\u6563\u304c\u5927\u304d\u3044\uff0e\r\n\u56f32\u3000FIN56\u306e\u4f5c\u7528\u6a5f\u5e8f\u306e\u30e2\u30c7\u30eb\r\n"}