Considering that the presence of micro lesions or breaks in the cervical epithelium, possibly caused by sexual activity, is the requirement for HPV to access the HSPG receptor on basement membrane (Bousarghin et al., 2003) , combinational use of some biocompatible materials for mucosa wound healing, such as human collagen proteins (Hua et al., 2019) , may have synergistic or complementary effects against HPV infection.