CORD-19:02a009e42054081b441d0f4b203679c4b0cae38d JSONTXT

Annnotations TAB JSON ListView MergeView

CORD-19-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 58-63 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T2 236-241 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T3 831-838 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T4 1065-1072 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T5 1241-1252 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T6 1307-1314 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T7 1564-1571 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T8 1885-1890 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T9 3795-3800 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T10 4248-4259 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T11 4637-4645 Phenotype denotes lethargy http://purl.obolibrary.org/obo/HP_0001254
T12 4647-4663 Phenotype denotes mild proteinuria http://purl.obolibrary.org/obo/HP_0012595
T13 4668-4677 Phenotype denotes hematuria http://purl.obolibrary.org/obo/HP_0000790
T14 5283-5292 Phenotype denotes Hepatitis http://purl.obolibrary.org/obo/HP_0012115
T15 5337-5342 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T16 5395-5407 Phenotype denotes Valley Fever http://purl.obolibrary.org/obo/HP_0032249
T17 5402-5407 Phenotype denotes Fever http://purl.obolibrary.org/obo/HP_0001945
T18 5436-5448 Phenotype denotes Encephalitis http://purl.obolibrary.org/obo/HP_0002383
T19 8650-8654 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T20 10659-10666 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T21 10721-10732 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T22 10911-10915 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T23 13164-13168 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531
T24 20286-20291 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T25 20296-20307 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T26 21183-21193 Phenotype denotes stomatitis http://purl.obolibrary.org/obo/HP_0010280
T27 27516-27523 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T28 27681-27688 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T29 27792-27799 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T30 29649-29661 Phenotype denotes leukocytosis http://purl.obolibrary.org/obo/HP_0001974
T31 29666-29682 Phenotype denotes thrombocytopenia http://purl.obolibrary.org/obo/HP_0001873
T32 30236-30264 Phenotype denotes extramedullary hematopoiesis http://purl.obolibrary.org/obo/HP_0001978
T33 31189-31194 Phenotype denotes edema http://purl.obolibrary.org/obo/HP_0000969
T34 31239-31244 Phenotype denotes edema http://purl.obolibrary.org/obo/HP_0000969
T35 31253-31274 Phenotype denotes pulmonary infiltrates http://purl.obolibrary.org/obo/HP_0002113
T36 32804-32815 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T37 34452-34463 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T38 34672-34683 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T39 34685-34690 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T40 34696-34704 Phenotype denotes lethargy http://purl.obolibrary.org/obo/HP_0001254
T41 34932-34937 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T42 35266-35277 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T43 36315-36326 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T44 36371-36382 Phenotype denotes Proteinuria http://purl.obolibrary.org/obo/HP_0000093
T45 36387-36396 Phenotype denotes hematuria http://purl.obolibrary.org/obo/HP_0000790
T46 36459-36470 Phenotype denotes proteinuria http://purl.obolibrary.org/obo/HP_0000093
T47 36484-36493 Phenotype denotes hematuria http://purl.obolibrary.org/obo/HP_0000790
T48 36539-36550 Phenotype denotes proteinuria http://purl.obolibrary.org/obo/HP_0000093
T49 36554-36563 Phenotype denotes hematuria http://purl.obolibrary.org/obo/HP_0000790
T50 37856-37865 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T51 38258-38265 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T52 38676-38683 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T53 38849-38856 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T54 44780-44787 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T55 46378-46385 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T56 46519-46524 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T57 48741-48760 Phenotype denotes Acute kidney injury http://purl.obolibrary.org/obo/HP_0001919
T58 48795-48809 Phenotype denotes blurred vision http://purl.obolibrary.org/obo/HP_0000622
T59 48884-48900 Phenotype denotes pleural effusion http://purl.obolibrary.org/obo/HP_0002202
T60 48930-48943 Phenotype denotes renal failure http://purl.obolibrary.org/obo/HP_0000083
T61 49535-49546 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T62 49669-49680 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T63 49750-49761 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T64 50085-50096 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T65 50281-50292 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T66 50297-50305 Phenotype denotes lethargy http://purl.obolibrary.org/obo/HP_0001254
T67 51011-51022 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T68 51097-51108 Phenotype denotes proteinuria http://purl.obolibrary.org/obo/HP_0000093
T69 51113-51122 Phenotype denotes hematuria http://purl.obolibrary.org/obo/HP_0000790
T70 51151-51164 Phenotype denotes kidney damage http://purl.obolibrary.org/obo/HP_0000112
T71 51557-51568 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T72 51811-51822 Phenotype denotes proteinuria http://purl.obolibrary.org/obo/HP_0000093
T73 51851-51860 Phenotype denotes hematuria http://purl.obolibrary.org/obo/HP_0000790
T74 51940-51953 Phenotype denotes renal failure http://purl.obolibrary.org/obo/HP_0000083
T75 51958-51974 Phenotype denotes thrombocytopenia http://purl.obolibrary.org/obo/HP_0001873
T76 52045-52056 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824
T77 53764-53777 Phenotype denotes renal failure http://purl.obolibrary.org/obo/HP_0000083
T78 54712-54719 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T79 54782-54789 Phenotype denotes viremia http://purl.obolibrary.org/obo/HP_0020071
T80 56492-56503 Phenotype denotes weight loss http://purl.obolibrary.org/obo/HP_0001824

CORD-19-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T3232 26-35 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T1 26-35 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T81328 46-83 Disease denotes hemorrhagic fever with renal syndrome http://purl.obolibrary.org/obo/MONDO_0005784
T2 46-83 Disease denotes hemorrhagic fever with renal syndrome http://purl.obolibrary.org/obo/MONDO_0005784
T72347 224-261 Disease denotes hemorrhagic fever with renal syndrome http://purl.obolibrary.org/obo/MONDO_0005784
T3 224-261 Disease denotes hemorrhagic fever with renal syndrome http://purl.obolibrary.org/obo/MONDO_0005784
T54101 263-267 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T4 263-267 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T68562 358-367 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T5 358-367 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T53071 430-434 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T6 430-434 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T4862 515-524 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T7 515-524 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T44532 587-596 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T8 587-596 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T64984 616-625 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T9 616-625 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T71857 657-667 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T10 657-667 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T18835 794-803 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T11 794-803 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T15468 915-924 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12 915-924 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T10056 1117-1126 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T13 1117-1126 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T98326 1526-1535 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T14 1526-1535 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T39139 1660-1680 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T15 1660-1680 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T69190 1671-1680 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T16 1671-1680 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91506 1708-1720 Disease denotes Hantaviruses http://purl.obolibrary.org/obo/MONDO_0017879
T17 1708-1720 Disease denotes Hantaviruses http://purl.obolibrary.org/obo/MONDO_0017879
T61916 1873-1910 Disease denotes hemorrhagic fever with renal syndrome http://purl.obolibrary.org/obo/MONDO_0005784
T18 1873-1910 Disease denotes hemorrhagic fever with renal syndrome http://purl.obolibrary.org/obo/MONDO_0005784
T22982 1912-1916 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T19 1912-1916 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T68609 1922-1951 Disease denotes hantavirus pulmonary syndrome http://purl.obolibrary.org/obo/MONDO_0017879
T20 1922-1951 Disease denotes hantavirus pulmonary syndrome http://purl.obolibrary.org/obo/MONDO_0017879
T37091 1953-1956 Disease denotes HPS http://purl.obolibrary.org/obo/MONDO_0017879
T21 1953-1956 Disease denotes HPS http://purl.obolibrary.org/obo/MONDO_0017879
T44173 2099-2103 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T24 2099-2103 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T79912 2207-2211 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T25 2207-2211 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T47823 2356-2360 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T26 2356-2360 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T22342 2364-2367 Disease denotes HPS http://purl.obolibrary.org/obo/MONDO_0017879
T96363 2364-2370 Disease denotes HPS [5 http://purl.obolibrary.org/obo/MONDO_0013557
T28 2364-2367 Disease denotes HPS http://purl.obolibrary.org/obo/MONDO_0017879
T27 2364-2370 Disease denotes HPS [5 http://purl.obolibrary.org/obo/MONDO_0013557
T3726 2452-2472 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T31 2452-2472 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T55214 2463-2472 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T32 2463-2472 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T33559 2509-2512 Disease denotes HPS http://purl.obolibrary.org/obo/MONDO_0017879
T33 2509-2512 Disease denotes HPS http://purl.obolibrary.org/obo/MONDO_0017879
T2642 2521-2531 Disease denotes hantavirus http://purl.obolibrary.org/obo/MONDO_0017879
T36 2521-2531 Disease denotes hantavirus http://purl.obolibrary.org/obo/MONDO_0017879
T65524 2610-2613 Disease denotes HPS http://purl.obolibrary.org/obo/MONDO_0017879
T37 2610-2613 Disease denotes HPS http://purl.obolibrary.org/obo/MONDO_0017879
T97673 2799-2802 Disease denotes HPS http://purl.obolibrary.org/obo/MONDO_0017879
T40 2799-2802 Disease denotes HPS http://purl.obolibrary.org/obo/MONDO_0017879
T59137 2849-2853 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T43 2849-2853 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T75236 2949-2958 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T44 2949-2958 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T51906 3156-3166 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T45 3156-3166 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T25552 3406-3415 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T46 3406-3415 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T11337 3578-3587 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T47 3578-3587 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T96859 3831-3836 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T48 3831-3836 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T40601 4064-4079 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T49 4064-4079 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T41565 4070-4079 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T50 4070-4079 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T82265 4363-4372 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T51 4363-4372 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T82467 4490-4499 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T52 4490-4499 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T77606 4531-4540 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T53 4531-4540 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T19419 4652-4663 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T54 4652-4663 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T32396 4717-4721 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T55 4717-4721 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T12998 5004-5022 Disease denotes infectious disease http://purl.obolibrary.org/obo/MONDO_0005550
T56 5004-5022 Disease denotes infectious disease http://purl.obolibrary.org/obo/MONDO_0005550
T97013 5263-5269 Disease denotes Dengue http://purl.obolibrary.org/obo/MONDO_0005502
T57 5263-5269 Disease denotes Dengue http://purl.obolibrary.org/obo/MONDO_0005502
T37976 5283-5292 Disease denotes Hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T87514 5283-5294 Disease denotes Hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T59 5283-5292 Disease denotes Hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T58 5283-5294 Disease denotes Hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T30271 5308-5317 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T60 5308-5317 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T68049 5331-5342 Disease denotes Lassa fever http://purl.obolibrary.org/obo/MONDO_0005820
T61 5331-5342 Disease denotes Lassa fever http://purl.obolibrary.org/obo/MONDO_0005820
T67054 5390-5407 Disease denotes Rift Valley Fever http://purl.obolibrary.org/obo/MONDO_0017880
T62 5390-5407 Disease denotes Rift Valley Fever http://purl.obolibrary.org/obo/MONDO_0017880
T4853 5395-5407 Disease denotes Valley Fever http://purl.obolibrary.org/obo/MONDO_0005706
T63 5395-5407 Disease denotes Valley Fever http://purl.obolibrary.org/obo/MONDO_0005706
T39834 5421-5448 Disease denotes Eastern Equine Encephalitis http://purl.obolibrary.org/obo/MONDO_0005736
T64 5421-5448 Disease denotes Eastern Equine Encephalitis http://purl.obolibrary.org/obo/MONDO_0005736
T90112 5436-5448 Disease denotes Encephalitis http://purl.obolibrary.org/obo/MONDO_0019956
T65 5436-5448 Disease denotes Encephalitis http://purl.obolibrary.org/obo/MONDO_0019956
T87299 5571-5580 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T66 5571-5580 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T15447 5666-5686 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T67 5666-5686 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T95424 5677-5686 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T68 5677-5686 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T45459 5853-5871 Disease denotes infectious disease http://purl.obolibrary.org/obo/MONDO_0005550
T69 5853-5871 Disease denotes infectious disease http://purl.obolibrary.org/obo/MONDO_0005550
T30548 5931-5940 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T70 5931-5940 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T98784 5965-5974 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T71 5965-5974 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T49278 6084-6093 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T72 6084-6093 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T63700 6149-6156 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T73 6149-6156 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T93286 8921-8930 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T74 8921-8930 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T46433 14517-14519 Disease denotes OD http://purl.obolibrary.org/obo/MONDO_0017178
T75 14517-14519 Disease denotes OD http://purl.obolibrary.org/obo/MONDO_0017178
T68663 14693-14695 Disease denotes OD http://purl.obolibrary.org/obo/MONDO_0017178
T76 14693-14695 Disease denotes OD http://purl.obolibrary.org/obo/MONDO_0017178
T4670 14935-14944 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T77 14935-14944 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T65911 15001-15010 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T78 15001-15010 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T14758 16367-16376 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T79 16367-16376 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T93202 17351-17360 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T80 17351-17360 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T76782 17761-17777 Disease denotes gland, pituitary http://purl.obolibrary.org/obo/MONDO_0021156
T81 17761-17777 Disease denotes gland, pituitary http://purl.obolibrary.org/obo/MONDO_0021156
T53266 19773-19780 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T82 19773-19780 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T66730 19914-19923 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T83 19914-19923 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T72067 20235-20244 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T84 20235-20244 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T70857 20260-20269 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T85 20260-20269 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T7644 21173-21193 Disease denotes vesicular stomatitis http://purl.obolibrary.org/obo/MONDO_0025028
T86 21173-21193 Disease denotes vesicular stomatitis http://purl.obolibrary.org/obo/MONDO_0025028
T47775 21183-21193 Disease denotes stomatitis http://purl.obolibrary.org/obo/MONDO_0004842
T87 21183-21193 Disease denotes stomatitis http://purl.obolibrary.org/obo/MONDO_0004842
T63189 22869-22879 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T88 22869-22879 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T69709 23495-23504 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T89 23495-23504 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12931 23776-23785 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T90 23776-23785 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T343 23822-23831 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91 23822-23831 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T38717 24033-24042 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T92 24033-24042 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T12887 24053-24057 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T93 24053-24057 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T55450 24318-24327 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T94 24318-24327 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T85047 24480-24489 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T95 24480-24489 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T20101 24511-24520 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T96 24511-24520 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T64637 24562-24571 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T97 24562-24571 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91435 24689-24698 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T98 24689-24698 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91518 25426-25435 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T99 25426-25435 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T69703 25632-25641 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T100 25632-25641 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T25435 25765-25774 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T101 25765-25774 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T18380 25964-25973 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T102 25964-25973 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T1450 26118-26127 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T103 26118-26127 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T77135 26154-26163 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T104 26154-26163 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T25335 26261-26270 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T105 26261-26270 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T73284 26471-26480 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T106 26471-26480 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T64633 26874-26883 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T107 26874-26883 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T58812 27014-27023 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T108 27014-27023 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T28488 27278-27287 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T109 27278-27287 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T50342 27489-27498 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T110 27489-27498 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T60826 27603-27612 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T111 27603-27612 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T41769 27961-27965 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T112 27961-27965 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T12034 27977-27997 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T113 27977-27997 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T98863 27988-27997 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T114 27988-27997 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91817 28141-28151 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T115 28141-28151 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T39682 28269-28278 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T116 28269-28278 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T44834 28347-28357 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T117 28347-28357 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T71823 28416-28425 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T118 28416-28425 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91286 28427-28437 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T119 28427-28437 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T59876 28550-28560 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T120 28550-28560 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T13148 28695-28705 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T121 28695-28705 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T47957 28773-28777 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T122 28773-28777 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T30794 28789-28809 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T123 28789-28809 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T82989 28800-28809 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T124 28800-28809 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T70293 28817-28826 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T125 28817-28826 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T95536 28841-28851 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T126 28841-28851 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T27555 28954-28964 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T127 28954-28964 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T8895 29195-29204 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T128 29195-29204 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T37045 29281-29291 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T129 29281-29291 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T13198 29546-29555 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T130 29546-29555 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T31347 29563-29573 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T131 29563-29573 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T71942 29623-29627 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T132 29623-29627 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T95287 29666-29682 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T133 29666-29682 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T88835 29690-29699 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T134 29690-29699 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T65291 29736-29745 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T135 29736-29745 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T64851 30212-30223 Disease denotes hyperplasia http://purl.obolibrary.org/obo/MONDO_0005043
T136 30212-30223 Disease denotes hyperplasia http://purl.obolibrary.org/obo/MONDO_0005043
T26329 30427-30436 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T137 30427-30436 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T77597 30544-30553 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T138 30544-30553 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91542 30582-30594 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T68996 30582-30613 Disease denotes inflammation of the pericardium http://purl.obolibrary.org/obo/MONDO_0005904
T140 30582-30594 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T139 30582-30613 Disease denotes inflammation of the pericardium http://purl.obolibrary.org/obo/MONDO_0005904
T1711 30879-30885 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T141 30879-30885 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T58779 30959-30968 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T142 30959-30968 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T11809 31091-31114 Disease denotes histiocytic infiltrates http://purl.obolibrary.org/obo/MONDO_0002637
T143 31091-31114 Disease denotes histiocytic infiltrates http://purl.obolibrary.org/obo/MONDO_0002637
T94409 31449-31458 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T144 31449-31458 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T82148 32143-32153 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T145 32143-32153 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T78669 32356-32376 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T146 32356-32376 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T50441 32367-32376 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T147 32367-32376 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T58032 32510-32519 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T148 32510-32519 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T2976 33021-33030 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T149 33021-33030 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T76234 33186-33195 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T150 33186-33195 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T17968 33373-33382 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T151 33373-33382 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T58127 33448-33457 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T152 33448-33457 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T49852 33571-33581 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T153 33571-33581 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T76578 34230-34240 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T154 34230-34240 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T64316 34722-34731 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T155 34722-34731 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91584 35396-35405 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T156 35396-35405 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T62521 35459-35468 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T157 35459-35468 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T71691 35589-35593 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T158 35589-35593 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T72325 35602-35612 Disease denotes hantavirus http://purl.obolibrary.org/obo/MONDO_0017879
T159 35602-35612 Disease denotes hantavirus http://purl.obolibrary.org/obo/MONDO_0017879
T13116 35620-35629 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T160 35620-35629 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T59203 36096-36105 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T161 36096-36105 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T90504 36179-36188 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T162 36179-36188 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T28498 36237-36246 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T163 36237-36246 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T7976 36371-36382 Disease denotes Proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T164 36371-36382 Disease denotes Proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T85034 36419-36428 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T165 36419-36428 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T47130 36459-36470 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T166 36459-36470 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T32203 36539-36550 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T167 36539-36550 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T87697 36715-36729 Disease denotes kidney failure http://purl.obolibrary.org/obo/MONDO_0001106
T168 36715-36729 Disease denotes kidney failure http://purl.obolibrary.org/obo/MONDO_0001106
T11854 36826-36836 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T169 36826-36836 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T19345 37118-37127 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T170 37118-37127 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T36406 37228-37240 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T171 37228-37240 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T994 37313-37325 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T172 37313-37325 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T67210 37424-37433 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T173 37424-37433 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T8375 37715-37729 Disease denotes endocrinopathy http://purl.obolibrary.org/obo/MONDO_0005151
T174 37715-37729 Disease denotes endocrinopathy http://purl.obolibrary.org/obo/MONDO_0005151
T31047 37841-37850 Disease denotes enteritis http://purl.obolibrary.org/obo/MONDO_0043579
T175 37841-37850 Disease denotes enteritis http://purl.obolibrary.org/obo/MONDO_0043579
T13511 37856-37865 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T176 37856-37865 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T33665 37974-37989 Disease denotes pituitary gland http://purl.obolibrary.org/obo/MONDO_0021156
T177 37974-37989 Disease denotes pituitary gland http://purl.obolibrary.org/obo/MONDO_0021156
T45885 38105-38125 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T178 38105-38125 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T43105 38116-38125 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T179 38116-38125 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T81510 38370-38379 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T180 38370-38379 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T92427 38537-38546 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T181 38537-38546 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T6652 38818-38827 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T182 38818-38827 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91312 38899-38908 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T183 38899-38908 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T13380 38950-38959 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T184 38950-38959 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T93252 38969-38973 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T185 38969-38973 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T15997 38982-38992 Disease denotes hantavirus http://purl.obolibrary.org/obo/MONDO_0017879
T186 38982-38992 Disease denotes hantavirus http://purl.obolibrary.org/obo/MONDO_0017879
T37601 39003-39009 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T187 39003-39009 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T45187 39115-39124 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T188 39115-39124 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T20708 39240-39249 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T189 39240-39249 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T73072 39296-39306 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T190 39296-39306 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T66924 39433-39444 Disease denotes hyperplasia http://purl.obolibrary.org/obo/MONDO_0005043
T191 39433-39444 Disease denotes hyperplasia http://purl.obolibrary.org/obo/MONDO_0005043
T11660 39612-39623 Disease denotes hyperplasia http://purl.obolibrary.org/obo/MONDO_0005043
T192 39612-39623 Disease denotes hyperplasia http://purl.obolibrary.org/obo/MONDO_0005043
T18935 39762-39766 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T193 39762-39766 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T23326 39778-39798 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T194 39778-39798 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T55786 39789-39798 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T195 39789-39798 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T55423 40347-40355 Disease denotes vaccinia http://purl.obolibrary.org/obo/MONDO_0002595
T196 40347-40355 Disease denotes vaccinia http://purl.obolibrary.org/obo/MONDO_0002595
T43920 41024-41028 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T197 41024-41028 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T47269 41159-41163 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T198 41159-41163 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T34987 41172-41192 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T199 41172-41192 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T58680 41183-41192 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T200 41183-41192 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T28999 41763-41772 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T201 41763-41772 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T76563 42152-42162 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T202 42152-42162 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T53076 42290-42299 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T203 42290-42299 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T80835 42367-42377 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T204 42367-42377 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T27161 42458-42467 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T205 42458-42467 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T92923 42957-42967 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T206 42957-42967 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T29754 43136-43146 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T207 43136-43146 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T89178 43344-43354 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T208 43344-43354 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T80713 43666-43675 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T209 43666-43675 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T9007 44048-44057 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T210 44048-44057 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T65105 44482-44491 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T211 44482-44491 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T35045 44568-44578 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T212 44568-44578 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T66390 44743-44752 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T213 44743-44752 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T1876 45021-45030 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T214 45021-45030 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T16780 45357-45366 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T215 45357-45366 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T97927 45838-45840 Disease denotes OD http://purl.obolibrary.org/obo/MONDO_0017178
T216 45838-45840 Disease denotes OD http://purl.obolibrary.org/obo/MONDO_0017178
T19949 45982-45991 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T217 45982-45991 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29923 46095-46104 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T218 46095-46104 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T9304 46343-46353 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T219 46343-46353 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T60074 46433-46442 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T220 46433-46442 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T74259 46656-46676 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T221 46656-46676 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T66696 46667-46676 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T222 46667-46676 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T82344 46758-46767 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T223 46758-46767 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T96446 46895-46904 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T224 46895-46904 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T50227 47149-47159 Disease denotes hantavirus http://purl.obolibrary.org/obo/MONDO_0017879
T225 47149-47159 Disease denotes hantavirus http://purl.obolibrary.org/obo/MONDO_0017879
T52757 47766-47768 Disease denotes OD http://purl.obolibrary.org/obo/MONDO_0017178
T226 47766-47768 Disease denotes OD http://purl.obolibrary.org/obo/MONDO_0017178
T227 47906-47921 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T54075 47906-47921 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T228 47912-47921 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T46812 47912-47921 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T229 48022-48031 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T80608 48022-48031 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T230 48413-48422 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T18090 48413-48422 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T231 48455-48465 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T90837 48455-48465 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T232 48501-48516 Disease denotes pituitary gland http://purl.obolibrary.org/obo/MONDO_0021156
T900 48501-48516 Disease denotes pituitary gland http://purl.obolibrary.org/obo/MONDO_0021156
T233 48741-48760 Disease denotes Acute kidney injury http://purl.obolibrary.org/obo/MONDO_0002492
T77831 48741-48760 Disease denotes Acute kidney injury http://purl.obolibrary.org/obo/MONDO_0002492
T234 48754-48760 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T31053 48754-48760 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T235 48930-48943 Disease denotes renal failure http://purl.obolibrary.org/obo/MONDO_0001106
T76843 48930-48943 Disease denotes renal failure http://purl.obolibrary.org/obo/MONDO_0001106
T236 49304-49313 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T45228 49304-49313 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T237 49343-49352 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T32533 49343-49352 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T238 49801-49811 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T90663 49801-49811 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T239 49895-49910 Disease denotes avian influenza http://purl.obolibrary.org/obo/MONDO_0018695
T14741 49895-49910 Disease denotes avian influenza http://purl.obolibrary.org/obo/MONDO_0018695
T240 49901-49910 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T29851 49901-49910 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T241 49987-49996 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T74905 49987-49996 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T242 50004-50013 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T57434 50004-50013 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T243 50019-50052 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T97362 50019-50052 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T244 50139-50148 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T11388 50139-50148 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T245 50264-50273 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T55542 50264-50273 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T246 50466-50475 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T58822 50466-50475 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T247 50884-50893 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T47998 50884-50893 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T248 50938-50948 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T56805 50938-50948 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T249 51051-51065 Disease denotes kidney failure http://purl.obolibrary.org/obo/MONDO_0001106
T48831 51051-51065 Disease denotes kidney failure http://purl.obolibrary.org/obo/MONDO_0001106
T250 51084-51088 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T16330 51084-51088 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T251 51097-51108 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T75584 51097-51108 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T252 51259-51263 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T1471 51259-51263 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T253 51393-51397 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T55719 51393-51397 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T254 51650-51664 Disease denotes kidney failure http://purl.obolibrary.org/obo/MONDO_0001106
T17561 51650-51664 Disease denotes kidney failure http://purl.obolibrary.org/obo/MONDO_0001106
T255 51811-51822 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T60825 51811-51822 Disease denotes proteinuria http://purl.obolibrary.org/obo/MONDO_0003634
T256 51940-51953 Disease denotes renal failure http://purl.obolibrary.org/obo/MONDO_0001106
T27500 51940-51953 Disease denotes renal failure http://purl.obolibrary.org/obo/MONDO_0001106
T257 51958-51974 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T56988 51958-51974 Disease denotes thrombocytopenia http://purl.obolibrary.org/obo/MONDO_0002049
T258 52370-52379 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T94659 52370-52379 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T259 52920-52929 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T58169 52920-52929 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T260 53017-53021 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T58086 53017-53021 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T261 53138-53147 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91725 53138-53147 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T262 53585-53589 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T14477 53585-53589 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T263 53598-53618 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T13588 53598-53618 Disease denotes hantavirus infection http://purl.obolibrary.org/obo/MONDO_0005780
T264 53609-53618 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T29035 53609-53618 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T265 53764-53777 Disease denotes renal failure http://purl.obolibrary.org/obo/MONDO_0001106
T83388 53764-53777 Disease denotes renal failure http://purl.obolibrary.org/obo/MONDO_0001106
T266 54021-54030 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T85446 54021-54030 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T267 54306-54316 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T31048 54306-54316 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T268 54383-54392 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T11106 54383-54392 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T269 54510-54519 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T54722 54510-54519 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T270 54752-54761 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T97761 54752-54761 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T271 54949-54959 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T9887 54949-54959 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T272 55300-55309 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T77647 55300-55309 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T273 55333-55337 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T87136 55333-55337 Disease denotes HFRS http://purl.obolibrary.org/obo/MONDO_0005784
T274 55549-55556 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T66767 55549-55556 Disease denotes sterile http://purl.obolibrary.org/obo/MONDO_0005047
T275 56025-56035 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T1314 56025-56035 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T276 56518-56537 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T52189 56518-56537 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T277 56528-56537 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T35940 56528-56537 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T278 56850-56860 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T53464 56850-56860 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T279 57046-57055 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T83502 57046-57055 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T280 57072-57082 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T13445 57072-57082 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T281 58154-58156 Disease denotes NS http://purl.obolibrary.org/obo/MONDO_0009735
T9279 58154-58156 Disease denotes NS http://purl.obolibrary.org/obo/MONDO_0009735

CORD-19-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 878-882 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 884-889 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T3 894-900 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T4 1261-1267 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T5 1301-1306 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T6 1342-1348 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T7 1558-1563 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T8 1598-1604 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T9 3683-3687 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T10 4003-4010 Body_part denotes excreta http://purl.obolibrary.org/obo/UBERON_0000174
T11 4683-4689 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T12 6498-6503 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T13 7545-7548 Body_part denotes tip http://purl.obolibrary.org/obo/UBERON_2001840
T14 7550-7555 Body_part denotes Blood http://purl.obolibrary.org/obo/UBERON_0000178
T15 7574-7583 Body_part denotes vena cava http://purl.obolibrary.org/obo/UBERON_0004087
T16 7683-7688 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T17 8406-8411 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T18 8432-8437 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T19 9554-9559 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T20 10773-10778 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T21 10811-10816 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T22 11870-11875 Body_part denotes Blood http://purl.obolibrary.org/obo/UBERON_0000178
T23 11892-11904 Body_part denotes femoral vein http://purl.obolibrary.org/obo/UBERON_0001361
T24 11900-11904 Body_part denotes vein http://purl.obolibrary.org/obo/UBERON_0001638
T25 12009-12014 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T26 12064-12069 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T27 12102-12107 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T28 15246-15251 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T29 15306-15311 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T30 15312-15318 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T31 16225-16230 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T32 16770-16775 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T33 16776-16782 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T34 16915-16920 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T35 16931-16936 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T36 17220-17225 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T37 17652-17657 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T38 17659-17663 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T39 17665-17670 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T40 17672-17678 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T41 17680-17686 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T42 17688-17693 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T43 17699-17704 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T44 17742-17751 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T45 17753-17766 Body_part denotes adrenal gland http://purl.obolibrary.org/obo/UBERON_0002369
T46 17761-17766 Body_part denotes gland http://purl.obolibrary.org/obo/UBERON_0002530
T47 17768-17783 Body_part denotes pituitary gland http://purl.obolibrary.org/obo/UBERON_0000007
T48 17778-17783 Body_part denotes gland http://purl.obolibrary.org/obo/UBERON_0002530
T49 17789-17792 Body_part denotes eye http://purl.obolibrary.org/obo/UBERON_0000970
T50 17869-17874 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T51 17876-17880 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T52 17882-17887 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T53 17889-17895 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T54 17897-17903 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T55 17905-17914 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T56 17920-17925 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T57 17993-17999 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T58 18255-18261 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T59 18971-18977 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T60 20608-20613 Body_part denotes Blood http://purl.obolibrary.org/obo/UBERON_0000178
T62 20666-20675 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982
T61 20666-20681 Body_part denotes capillary blood http://purl.obolibrary.org/obo/UBERON_0013757
T63 20676-20681 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T64 20859-20864 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T65 20927-20932 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T66 22358-22363 Body_part denotes Blood http://purl.obolibrary.org/obo/UBERON_0000178
T67 22381-22386 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T68 22397-22401 Body_part denotes tube http://purl.obolibrary.org/obo/UBERON_0000025
T69 22660-22665 Body_part denotes Urine http://purl.obolibrary.org/obo/UBERON_0001088
T70 22965-22970 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T71 25782-25787 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T72 25789-25793 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T73 25795-25800 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T74 25802-25808 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T75 25810-25816 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T76 25822-25827 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T77 26024-26029 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T78 26031-26035 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T79 26037-26043 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T80 26048-26053 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T81 26171-26177 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T82 26182-26187 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T83 26326-26331 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T84 26336-26340 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T85 26488-26493 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T86 26593-26599 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T87 26654-26660 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T88 26707-26713 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T89 26930-26936 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T90 26982-26988 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T91 27061-27066 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T92 27068-27073 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T93 27075-27081 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T94 27086-27091 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T95 27123-27129 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T96 27196-27200 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T97 27346-27351 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T98 27450-27455 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T99 27510-27515 Body_part denotes Serum http://purl.obolibrary.org/obo/UBERON_0001977
T100 27675-27680 Body_part denotes Serum http://purl.obolibrary.org/obo/UBERON_0001977
T101 27786-27791 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T102 27946-27951 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T103 28184-28189 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T104 28222-28226 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T105 28228-28233 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T106 28235-28241 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T107 28247-28253 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T108 28330-28336 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T109 28467-28471 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T110 28473-28478 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T111 28480-28485 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T112 28490-28496 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T113 28587-28592 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T114 28739-28745 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T115 28881-28886 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T116 28978-28984 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T117 29251-29257 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T118 29318-29323 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T119 29467-29472 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T120 29766-29771 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T121 29855-29860 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T122 29963-29969 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T123 30167-30173 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T124 30177-30182 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T125 30272-30277 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T126 30602-30613 Body_part denotes pericardium http://purl.obolibrary.org/obo/UBERON_0002407
T127 30764-30775 Body_part denotes pericardium http://purl.obolibrary.org/obo/UBERON_0002407
T128 30872-30878 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T129 31812-31817 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T130 31876-31880 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T131 31911-31917 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T132 32017-32022 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T133 32087-32092 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T134 32279-32285 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T135 33481-33487 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T136 33609-33613 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T137 33615-33620 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T138 33622-33628 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T139 33630-33639 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T140 33644-33649 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T141 33755-33760 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T142 33765-33771 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T143 33806-33811 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T144 33813-33817 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T145 33819-33825 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T146 33827-33836 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T147 33841-33846 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T148 33946-33951 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T149 33962-33968 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T150 34141-34147 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T151 34163-34172 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T152 34264-34269 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T153 35773-35778 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T154 35789-35794 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T155 35826-35832 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T156 36626-36631 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T157 36715-36721 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T158 36879-36884 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T159 36886-36891 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T160 36893-36897 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T161 36899-36904 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T162 36906-36912 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T163 36914-36920 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T164 36922-36931 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T165 36936-36939 Body_part denotes eye http://purl.obolibrary.org/obo/UBERON_0000970
T166 37257-37268 Body_part denotes bronchioles http://purl.obolibrary.org/obo/UBERON_0002186
T167 37346-37357 Body_part denotes bronchioles http://purl.obolibrary.org/obo/UBERON_0002186
T168 37370-37381 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T169 37591-37598 Body_part denotes capsule http://purl.obolibrary.org/obo/UBERON_0003893
T170 37602-37616 Body_part denotes adrenal cortex http://purl.obolibrary.org/obo/UBERON_0001235
T171 37610-37616 Body_part denotes cortex http://purl.obolibrary.org/obo/UBERON_0001851
T172 37919-37941 Body_part denotes atrioventricular valve http://purl.obolibrary.org/obo/UBERON_0002133
T173 37936-37941 Body_part denotes valve http://purl.obolibrary.org/obo/UBERON_0003978
T174 37947-37953 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T175 37955-37960 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T176 37962-37968 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T177 37974-37989 Body_part denotes pituitary gland http://purl.obolibrary.org/obo/UBERON_0000007
T178 37984-37989 Body_part denotes gland http://purl.obolibrary.org/obo/UBERON_0002530
T179 38198-38203 Body_part denotes Blood http://purl.obolibrary.org/obo/UBERON_0000178
T180 38252-38257 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T181 38278-38283 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T182 38639-38644 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T183 38670-38675 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T184 38843-38848 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T185 39042-39047 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T186 39065-39070 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T187 39163-39168 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T188 39261-39267 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T189 39349-39354 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T190 39356-39360 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T191 39362-39367 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T192 39369-39375 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T193 39377-39383 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T194 39385-39394 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T195 39398-39403 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T196 39543-39549 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T198 39559-39564 Body_part denotes lymph http://purl.obolibrary.org/obo/UBERON_0002391
T197 39559-39570 Body_part denotes lymph nodes http://purl.obolibrary.org/obo/UBERON_0000029
T199 39575-39605 Body_part denotes gut associated lymphoid tissue http://purl.obolibrary.org/obo/UBERON_0001962
T200 39590-39605 Body_part denotes lymphoid tissue http://purl.obolibrary.org/obo/UBERON_0001744
T201 39599-39605 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T202 42341-42346 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T203 42401-42405 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T204 42407-42412 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T205 42414-42420 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T206 42422-42428 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T207 42433-42438 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T208 42540-42545 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T209 42570-42575 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T210 42751-42756 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T211 42785-42791 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T212 42890-42896 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T213 44185-44189 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T214 44191-44196 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T215 44201-44207 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T216 44220-44226 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T217 44232-44237 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T218 44242-44247 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T219 44333-44338 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T220 44531-44537 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T221 44549-44553 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T222 44707-44712 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T223 44774-44779 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T224 44951-44955 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T225 44995-45001 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T226 45199-45203 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T227 45205-45211 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T228 45216-45222 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T229 45252-45257 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T230 45265-45270 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T231 45960-45966 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T232 46011-46016 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T233 46040-46046 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T234 46175-46180 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T235 46182-46188 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T236 46367-46372 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T237 47602-47607 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T238 47678-47683 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T239 48494-48499 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T240 48501-48516 Body_part denotes pituitary gland http://purl.obolibrary.org/obo/UBERON_0000007
T241 48511-48516 Body_part denotes gland http://purl.obolibrary.org/obo/UBERON_0002530
T242 48518-48522 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T243 48524-48529 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T244 48531-48536 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T245 48538-48544 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T246 48546-48552 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T247 48554-48573 Body_part denotes cerebrospinal fluid http://purl.obolibrary.org/obo/UBERON_0001359
T248 48747-48753 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T249 48884-48900 Body_part denotes pleural effusion http://purl.obolibrary.org/obo/UBERON_0000175
T250 49138-49144 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T251 49263-49269 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T252 49454-49460 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T253 50728-50733 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T254 50978-50984 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T255 51051-51057 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T256 51151-51157 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T257 51190-51195 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T258 51196-51201 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T259 51309-51315 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T260 51489-51495 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T261 51650-51656 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T262 51680-51685 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T263 53812-53817 Body_part denotes Serum http://purl.obolibrary.org/obo/UBERON_0001977
T264 54362-54367 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T265 54706-54711 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T266 54776-54781 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T267 55912-55917 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948
T268 55919-55923 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T269 55925-55930 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T270 55932-55938 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T271 55940-55946 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T272 55952-55961 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T273 56151-56156 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T274 56404-56409 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T275 56874-56880 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T276 56939-56944 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948
T277 56946-56950 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T278 56952-56957 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T279 56959-56965 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T280 56967-56973 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T281 56975-56984 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T282 56986-56991 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T283 56993-56996 Body_part denotes eye http://purl.obolibrary.org/obo/UBERON_0000970
T284 57002-57015 Body_part denotes adrenal gland http://purl.obolibrary.org/obo/UBERON_0002369
T285 57010-57015 Body_part denotes gland http://purl.obolibrary.org/obo/UBERON_0002530
T286 57419-57424 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T287 57761-57766 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T288 57850-57856 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T289 58009-58014 Body_part denotes Heart http://purl.obolibrary.org/obo/UBERON_0000948
T290 58020-58024 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T291 58030-58035 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T292 58041-58047 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T293 58053-58059 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T294 58065-58074 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T295 58084-58089 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955

CORD-19-Sentences

Id Subject Object Predicate Lexical cue
T93306 0-106 Sentence denotes Three asymptomatic animal infection models of hemorrhagic fever with renal syndrome caused by hantaviruses
TextSentencer_T1 0-106 Sentence denotes Three asymptomatic animal infection models of hemorrhagic fever with renal syndrome caused by hantaviruses
T23232 108-116 Sentence denotes Abstract
TextSentencer_T2 108-116 Sentence denotes Abstract
T77055 117-288 Sentence denotes Hantaan virus (HTNV) and Puumala virus (PUUV) are rodent-borne hantaviruses that are the primary causes of hemorrhagic fever with renal syndrome (HFRS) in Europe and Asia.
TextSentencer_T3 117-288 Sentence denotes Hantaan virus (HTNV) and Puumala virus (PUUV) are rodent-borne hantaviruses that are the primary causes of hemorrhagic fever with renal syndrome (HFRS) in Europe and Asia.
T76096 289-461 Sentence denotes The development of well characterized animal models of HTNV and PUUV infection is critical for the evaluation and the potential licensure of HFRS vaccines and therapeutics.
TextSentencer_T4 289-461 Sentence denotes The development of well characterized animal models of HTNV and PUUV infection is critical for the evaluation and the potential licensure of HFRS vaccines and therapeutics.
T98768 462-615 Sentence denotes In this study we present three animal models of HTNV infection (hamster, ferret and marmoset), and two animal models of PUUV infection (hamster, ferret).
TextSentencer_T5 462-615 Sentence denotes In this study we present three animal models of HTNV infection (hamster, ferret and marmoset), and two animal models of PUUV infection (hamster, ferret).
T61250 616-901 Sentence denotes Infection of hamsters with a~3 times the infectious dose 99% (ID 99 ) of HTNV by the intramuscular and~1 ID 99 of HTNV by the intranasal route leads to a persistent asymptomatic infection, characterized by sporadic viremia and high levels of viral genome in the lung, brain and kidney.
TextSentencer_T6 616-901 Sentence denotes Infection of hamsters with a~3 times the infectious dose 99% (ID 99 ) of HTNV by the intramuscular and~1 ID 99 of HTNV by the intranasal route leads to a persistent asymptomatic infection, characterized by sporadic viremia and high levels of viral genome in the lung, brain and kidney.
T6943 902-1116 Sentence denotes In contrast, infection of hamsters with~2 ID 99 of PUUV by the intramuscular or~1 ID 99 of PUUV by the intranasal route leads to seroconversion with no detectable viremia, and a transient detection of viral genome.
TextSentencer_T7 902-1116 Sentence denotes In contrast, infection of hamsters with~2 ID 99 of PUUV by the intramuscular or~1 ID 99 of PUUV by the intranasal route leads to seroconversion with no detectable viremia, and a transient detection of viral genome.
T67680 1117-1366 Sentence denotes Infection of ferrets with a high dose of either HTNV or PUUV by the intramuscular route leads to seroconversion and gradual weight loss, though kidney function remained unimpaired and serum viremia and viral dissemination to organs was not detected.
TextSentencer_T8 1117-1366 Sentence denotes Infection of ferrets with a high dose of either HTNV or PUUV by the intramuscular route leads to seroconversion and gradual weight loss, though kidney function remained unimpaired and serum viremia and viral dissemination to organs was not detected.
T60961 1367-1487 Sentence denotes In marmosets a 1,000 PFU HTNV intramuscular challenge led to robust seroconversion and neutralizing antibody production.
TextSentencer_T9 1367-1487 Sentence denotes In marmosets a 1,000 PFU HTNV intramuscular challenge led to robust seroconversion and neutralizing antibody production.
T10249 1488-1631 Sentence denotes Similarly to the ferret model of HTNV infection, no renal impairment, serum viremia or viral dissemination to organs was detected in marmosets.
TextSentencer_T10 1488-1631 Sentence denotes Similarly to the ferret model of HTNV infection, no renal impairment, serum viremia or viral dissemination to organs was detected in marmosets.
T96567 1632-1706 Sentence denotes This is the first report of hantavirus infection in ferrets and marmosets.
TextSentencer_T11 1632-1706 Sentence denotes This is the first report of hantavirus infection in ferrets and marmosets.
T82130 1708-1798 Sentence denotes Hantaviruses are negative-sense RNA viruses transmitted to humans from small animal hosts.
TextSentencer_T12 1708-1798 Sentence denotes Hantaviruses are negative-sense RNA viruses transmitted to humans from small animal hosts.
T53923 1799-1963 Sentence denotes Different viral species are associated with one of two disease syndromes: hemorrhagic fever with renal syndrome (HFRS), or hantavirus pulmonary syndrome (HPS) [1] .
TextSentencer_T13 1799-1963 Sentence denotes Different viral species are associated with one of two disease syndromes: hemorrhagic fever with renal syndrome (HFRS), or hantavirus pulmonary syndrome (HPS) [1] .
T32493 1964-2173 Sentence denotes Hantaan virus a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 (HTNV), primarily found in Asia, is among the most prevalent HFRS-causing hantaviruses with a case fatality rate of between 1-15% [2] .
TextSentencer_T14 1964-2173 Sentence denotes Hantaan virus a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 (HTNV), primarily found in Asia, is among the most prevalent HFRS-causing hantaviruses with a case fatality rate of between 1-15% [2] .
T56812 2174-2283 Sentence denotes Puumala virus (PUUV) causes most HFRS cases in Europe, though its case fatality rate is lower at <1% [3, 4] .
TextSentencer_T15 2174-2283 Sentence denotes Puumala virus (PUUV) causes most HFRS cases in Europe, though its case fatality rate is lower at <1% [3, 4] .
T63427 2284-2373 Sentence denotes There are currently no FDA licensed vaccines or therapeutics for either HFRS or HPS [5] .
TextSentencer_T16 2284-2373 Sentence denotes There are currently no FDA licensed vaccines or therapeutics for either HFRS or HPS [5] .
T5320 2374-2485 Sentence denotes The Syrian hamster (Mesocricetus auratus) is the typical animal used to model hantavirus infection and disease.
TextSentencer_T17 2374-2485 Sentence denotes The Syrian hamster (Mesocricetus auratus) is the typical animal used to model hantavirus infection and disease.
T93256 2486-2783 Sentence denotes Andes virus (ANDV), an HPS-causing hantavirus, causes lethal disease in immunocompetent hamsters [6] , while numerous other HPS-causing hantaviruses including Sin Nombre Virus (SNV) and Choclo virus cause lethal disease in hamsters immunosuppressed with dexamethasone and cyclophosphamide [7, 8] .
TextSentencer_T18 2486-2783 Sentence denotes Andes virus (ANDV), an HPS-causing hantavirus, causes lethal disease in immunocompetent hamsters [6] , while numerous other HPS-causing hantaviruses including Sin Nombre Virus (SNV) and Choclo virus cause lethal disease in hamsters immunosuppressed with dexamethasone and cyclophosphamide [7, 8] .
T22030 2784-3066 Sentence denotes In contrast to HPS-causing hantaviruses, exposure of hamsters to HFRS-causing hantaviruses such as HTNV, PUUV, Dobrava (DOBV) and Seoul (SEOV) leads to asymptomatic infection, despite viral dissemination, even when immunosuppressed (Hooper Lab, unpublished data) [8] [9] [10] [11] .
TextSentencer_T19 2784-3066 Sentence denotes In contrast to HPS-causing hantaviruses, exposure of hamsters to HFRS-causing hantaviruses such as HTNV, PUUV, Dobrava (DOBV) and Seoul (SEOV) leads to asymptomatic infection, despite viral dissemination, even when immunosuppressed (Hooper Lab, unpublished data) [8] [9] [10] [11] .
T29803 3067-3199 Sentence denotes In these studies hamsters were exposed to high doses of HTNV and PUUV, far exceeding the infectious dose 99% (ID 99 ) for the virus.
TextSentencer_T20 3067-3199 Sentence denotes In these studies hamsters were exposed to high doses of HTNV and PUUV, far exceeding the infectious dose 99% (ID 99 ) for the virus.
T92505 3200-3360 Sentence denotes Development and characterization of a uniformly infective, low-dose challenge model, enhances the hamster model's usefulness in vaccine and therapeutic testing.
TextSentencer_T21 3200-3360 Sentence denotes Development and characterization of a uniformly infective, low-dose challenge model, enhances the hamster model's usefulness in vaccine and therapeutic testing.
T6217 3361-3462 Sentence denotes In this report we present a low-dose hamster infection model for both HTNV and PUUV infected animals.
TextSentencer_T22 3361-3462 Sentence denotes In this report we present a low-dose hamster infection model for both HTNV and PUUV infected animals.
T75074 3463-3709 Sentence denotes Ferrets (Mustela putorius furo) have become a popular animal model for a number of respiratory pathogens including influenza [12] , coronavirus [13] , Nipah virus [14] , and morbillivirus [15] , due to the similarity in lung physiology to humans.
TextSentencer_T23 3463-3709 Sentence denotes Ferrets (Mustela putorius furo) have become a popular animal model for a number of respiratory pathogens including influenza [12] , coronavirus [13] , Nipah virus [14] , and morbillivirus [15] , due to the similarity in lung physiology to humans.
T5461 3710-3908 Sentence denotes In addition, they have recently been described as a disease model of two hemorrhagic fever viruses, Bundibugyo virus and Ebola virus [16, 17] , supporting viral replication without prior adaptation.
TextSentencer_T24 3710-3908 Sentence denotes In addition, they have recently been described as a disease model of two hemorrhagic fever viruses, Bundibugyo virus and Ebola virus [16, 17] , supporting viral replication without prior adaptation.
T80457 3909-4116 Sentence denotes Most hantavirusrelated human disease occurs by aerosolized transmission of the virus from the excreta or secreta of infected rodents [18, 19] , a model of viral infection for which the ferret is well suited.
TextSentencer_T25 3909-4116 Sentence denotes Most hantavirusrelated human disease occurs by aerosolized transmission of the virus from the excreta or secreta of infected rodents [18, 19] , a model of viral infection for which the ferret is well suited.
T41405 4117-4333 Sentence denotes In this study we demonstrate that ferrets are capable of being infected by high titers of HTNV and PUUV, though aside from gradual weight loss infected animals exhibit no clinical symptoms or impaired renal function.
TextSentencer_T26 4117-4333 Sentence denotes In this study we demonstrate that ferrets are capable of being infected by high titers of HTNV and PUUV, though aside from gradual weight loss infected animals exhibit no clinical symptoms or impaired renal function.
T13552 4334-4738 Sentence denotes It has been established that infection of rhesus macaques (Macaca mulatta) with HFRScausing hantaviruses (DOBV, SEOV, HTNV, and PUUV) leads to asymptomatic infection and seroconversion [9] , while infection of cynomolgus macaques (Macaca fascicularis) with PUUV leads to a mild disease characterized by lethargy, mild proteinuria and hematuria, and kidney pathology, similar to mild HFRS in humans [20] .
TextSentencer_T27 4334-4738 Sentence denotes It has been established that infection of rhesus macaques (Macaca mulatta) with HFRScausing hantaviruses (DOBV, SEOV, HTNV, and PUUV) leads to asymptomatic infection and seroconversion [9] , while infection of cynomolgus macaques (Macaca fascicularis) with PUUV leads to a mild disease characterized by lethargy, mild proteinuria and hematuria, and kidney pathology, similar to mild HFRS in humans [20] .
T72194 4739-4933 Sentence denotes However, the macaques' large size and cost limits their usefulness in therapeutic studies, especially when test article availability is limited, as is often the case in passive transfer studies.
TextSentencer_T28 4739-4933 Sentence denotes However, the macaques' large size and cost limits their usefulness in therapeutic studies, especially when test article availability is limited, as is often the case in passive transfer studies.
T92336 4934-5031 Sentence denotes The common marmoset (Callithrix jacchus) is becoming more popular for infectious disease studies.
TextSentencer_T29 4934-5031 Sentence denotes The common marmoset (Callithrix jacchus) is becoming more popular for infectious disease studies.
T41590 5032-5185 Sentence denotes Its genetic similarity to humans, cost, relative safety, and small size make it an attractive alternative to traditional non-human primate species [21] .
TextSentencer_T30 5032-5185 Sentence denotes Its genetic similarity to humans, cost, relative safety, and small size make it an attractive alternative to traditional non-human primate species [21] .
T58449 5186-5484 Sentence denotes Marmosets have been used as a disease model for other viral agents including Dengue virus [22] , Hepatitis C virus [23] , influenza virus [24] , Lassa fever virus [25] , orthopox viruses [26] [27] [28] , Rift Valley Fever virus [29] , Eastern Equine Encephalitis virus [30] , and filoviruses [31] .
TextSentencer_T31 5186-5484 Sentence denotes Marmosets have been used as a disease model for other viral agents including Dengue virus [22] , Hepatitis C virus [23] , influenza virus [24] , Lassa fever virus [25] , orthopox viruses [26] [27] [28] , Rift Valley Fever virus [29] , Eastern Equine Encephalitis virus [30] , and filoviruses [31] .
T68718 5485-5637 Sentence denotes In this study we demonstrate that exposure of marmosets to HTNV leads to asymptomatic infection characterized by high levels of neutralizing antibodies.
TextSentencer_T32 5485-5637 Sentence denotes In this study we demonstrate that exposure of marmosets to HTNV leads to asymptomatic infection characterized by high levels of neutralizing antibodies.
T88370 5638-5700 Sentence denotes This is the first report of hantavirus infection in marmosets.
TextSentencer_T33 5638-5700 Sentence denotes This is the first report of hantavirus infection in marmosets.
T3091 5701-5882 Sentence denotes Medical countermeasures are products including biologics (e.g., vaccines and antibodies) and small molecule drugs that can be used to prevent or combat infectious disease outbreaks.
TextSentencer_T34 5701-5882 Sentence denotes Medical countermeasures are products including biologics (e.g., vaccines and antibodies) and small molecule drugs that can be used to prevent or combat infectious disease outbreaks.
T30828 5883-6166 Sentence denotes This study presents three animal models of HTNV infection, and two models of PUUV infection that can be used to evaluate the efficacy of medical countermeasure that are intended to prevent or mitigate infection (e.g., vaccines) by these viruses through induction of sterile immunity.
TextSentencer_T35 5883-6166 Sentence denotes This study presents three animal models of HTNV infection, and two models of PUUV infection that can be used to evaluate the efficacy of medical countermeasure that are intended to prevent or mitigate infection (e.g., vaccines) by these viruses through induction of sterile immunity.
T22027 6167-6668 Sentence denotes HTNV strain 76-118 [32] , PUUV strain K27 [33] , and PUUV strains Beaumont, and Seloignes (gifts of Piet Maes, Leuven, Beligium) were propagated in Vero E6 cells (Vero C1008, ATCC CRL 1586) in T-150 flasks and cEMEM media (Eagle 0 s minimal essential medium with Earle 0 s salts (EMEM) containing 10% heat inactivated fetal bovine serum, 200 μM glutamine, 1% non-essential amino acids, 10 mM HEPES pH 7.4; and antibiotics [penicillin (100 U/ml), amphotericin B (250 μg/ml), and gentamicin (50 mg/ml)].
TextSentencer_T36 6167-6668 Sentence denotes HTNV strain 76-118 [32] , PUUV strain K27 [33] , and PUUV strains Beaumont, and Seloignes (gifts of Piet Maes, Leuven, Beligium) were propagated in Vero E6 cells (Vero C1008, ATCC CRL 1586) in T-150 flasks and cEMEM media (Eagle 0 s minimal essential medium with Earle 0 s salts (EMEM) containing 10% heat inactivated fetal bovine serum, 200 μM glutamine, 1% non-essential amino acids, 10 mM HEPES pH 7.4; and antibiotics [penicillin (100 U/ml), amphotericin B (250 μg/ml), and gentamicin (50 mg/ml)].
T10172 6669-6725 Sentence denotes Virus was collected from infectedmonolayer supernatants.
TextSentencer_T37 6669-6725 Sentence denotes Virus was collected from infectedmonolayer supernatants.
T68561 6726-6815 Sentence denotes Cell debris was removed by low speed centrifugation (2500 rpm in a table top centrifuge).
TextSentencer_T38 6726-6815 Sentence denotes Cell debris was removed by low speed centrifugation (2500 rpm in a table top centrifuge).
T88323 6816-6904 Sentence denotes HTNV and PUUV strain K27 were twice plaque purified according to published methods [6] .
TextSentencer_T39 6816-6904 Sentence denotes HTNV and PUUV strain K27 were twice plaque purified according to published methods [6] .
T38472 6905-6963 Sentence denotes Virus stocks were aliquoted and stored at -60˚C or colder.
TextSentencer_T40 6905-6963 Sentence denotes Virus stocks were aliquoted and stored at -60˚C or colder.
T62302 6964-7026 Sentence denotes Virus identity has been confirmed by sequencing of the stocks.
TextSentencer_T41 6964-7026 Sentence denotes Virus identity has been confirmed by sequencing of the stocks.
T20395 7028-7196 Sentence denotes Female Syrian hamsters 6-8 wks of age (Envigo, Indianapolis, IN) were anesthetized by inhalation of vaporized isoflurane using an IMPAC 6 veterinary anesthesia machine.
TextSentencer_T42 7028-7196 Sentence denotes Female Syrian hamsters 6-8 wks of age (Envigo, Indianapolis, IN) were anesthetized by inhalation of vaporized isoflurane using an IMPAC 6 veterinary anesthesia machine.
T69679 7197-7295 Sentence denotes Once anesthetized, animals were injected with the indicated concentration of virus diluted in PBS.
TextSentencer_T43 7197-7295 Sentence denotes Once anesthetized, animals were injected with the indicated concentration of virus diluted in PBS.
T83872 7296-7430 Sentence denotes Intramuscular (i.m.) injections (in the caudal thigh) consisted of 0.2 ml delivered with a 1ml syringe with a 25-gauge, 5/8 in needle.
TextSentencer_T44 7296-7430 Sentence denotes Intramuscular (i.m.) injections (in the caudal thigh) consisted of 0.2 ml delivered with a 1ml syringe with a 25-gauge, 5/8 in needle.
T34422 7431-7549 Sentence denotes Intranasal (i.n.) instillation consisted of 50 μl total volume delivered as 25 μl per nare with a plastic pipette tip.
TextSentencer_T45 7431-7549 Sentence denotes Intranasal (i.n.) instillation consisted of 50 μl total volume delivered as 25 μl per nare with a plastic pipette tip.
T89690 7550-7705 Sentence denotes Blood sampling from the vena cava occurred under previously stated methods of anesthesia, and was limited to 7% of a hamster's total blood volume per week.
TextSentencer_T46 7550-7705 Sentence denotes Blood sampling from the vena cava occurred under previously stated methods of anesthesia, and was limited to 7% of a hamster's total blood volume per week.
T71502 7706-7774 Sentence denotes At time of arrival animals were randomized into experimental groups.
TextSentencer_T47 7706-7774 Sentence denotes At time of arrival animals were randomized into experimental groups.
T56936 7775-7957 Sentence denotes Animals were housed in small animal pans, not exceeding four animals to a pan, in a climate and humidity controlled animal biosafety level 3 (ABSL-3) with a 12-hour light/dark cycle.
TextSentencer_T48 7775-7957 Sentence denotes Animals were housed in small animal pans, not exceeding four animals to a pan, in a climate and humidity controlled animal biosafety level 3 (ABSL-3) with a 12-hour light/dark cycle.
T20627 7958-8014 Sentence denotes Animals had pelleted food and water provided ad libitum.
TextSentencer_T49 7958-8014 Sentence denotes Animals had pelleted food and water provided ad libitum.
T40380 8015-8101 Sentence denotes Enrichment in the form of toys, nesting material and supplemental treats was provided.
TextSentencer_T50 8015-8101 Sentence denotes Enrichment in the form of toys, nesting material and supplemental treats was provided.
T5270 8102-8297 Sentence denotes Humane endpoint conditions were established as decreased mobility (inability to obtain food and water) and subdued response to stimulation, and animals were monitored daily during the experiment.
TextSentencer_T51 8102-8297 Sentence denotes Humane endpoint conditions were established as decreased mobility (inability to obtain food and water) and subdued response to stimulation, and animals were monitored daily during the experiment.
T91082 8298-8623 Sentence denotes As infected animals did not become ill, these criteria were not met and animals were euthanized by terminal blood collection from the heart after administration of Ketamine-acepromazine-xylazine (KAX)(USAMRIID, Fort Detrick MD) and prior to intracardiac injection with pentobarbital sodium (USAMRIID) at the end of the study.
TextSentencer_T52 8298-8623 Sentence denotes As infected animals did not become ill, these criteria were not met and animals were euthanized by terminal blood collection from the heart after administration of Ketamine-acepromazine-xylazine (KAX)(USAMRIID, Fort Detrick MD) and prior to intracardiac injection with pentobarbital sodium (USAMRIID) at the end of the study.
T74116 8624-8717 Sentence denotes Due to lack of illness no pain relief, aside from anesthesia during procedures, was required.
TextSentencer_T53 8624-8717 Sentence denotes Due to lack of illness no pain relief, aside from anesthesia during procedures, was required.
T94458 8718-8859 Sentence denotes confidence intervals reaching out to 0.7log 10 (approximately 5-fold) under monotome assumptions of response profiles for intermediate doses.
TextSentencer_T54 8718-8859 Sentence denotes confidence intervals reaching out to 0.7log 10 (approximately 5-fold) under monotome assumptions of response profiles for intermediate doses.
T35059 8860-9008 Sentence denotes As our initial selection of dosages did not meet the desired infection rate span, some dosage groups were repeated leading to 20 hamsters per group.
TextSentencer_T55 8860-9008 Sentence denotes As our initial selection of dosages did not meet the desired infection rate span, some dosage groups were repeated leading to 20 hamsters per group.
T53100 9009-9075 Sentence denotes In the serial euthanasia study three hamsters per group were used.
TextSentencer_T56 9009-9075 Sentence denotes In the serial euthanasia study three hamsters per group were used.
T61060 9076-9214 Sentence denotes This is the minimum number required to provide collection of sufficient samples for detection of antibodies and viral kinetics in tissues.
TextSentencer_T57 9076-9214 Sentence denotes This is the minimum number required to provide collection of sufficient samples for detection of antibodies and viral kinetics in tissues.
T84462 9215-9284 Sentence denotes For each experiment pre-sera from animals served as negative control.
TextSentencer_T58 9215-9284 Sentence denotes For each experiment pre-sera from animals served as negative control.
T26211 9285-9522 Sentence denotes Adult, female neutered and descented ferrets (Marshall Farms, North Rose, NY), were anesthetized by inhalation of vaporized isoflurane using an IMPAC 6 veterinary anesthesia machine, or i.m. injection of Telazol (Zoetis, Parsippany, NJ).
TextSentencer_T59 9285-9522 Sentence denotes Adult, female neutered and descented ferrets (Marshall Farms, North Rose, NY), were anesthetized by inhalation of vaporized isoflurane using an IMPAC 6 veterinary anesthesia machine, or i.m. injection of Telazol (Zoetis, Parsippany, NJ).
T382 9523-9621 Sentence denotes Injections (i.m. and i.n.) and blood sampling were conducted under the same condition as hamsters.
TextSentencer_T60 9523-9621 Sentence denotes Injections (i.m. and i.n.) and blood sampling were conducted under the same condition as hamsters.
T93168 9622-9726 Sentence denotes Intraperitoneal (i.p.) injections consisted of 1 ml delivered with a 3 mL syringe and a 23-guage needle.
TextSentencer_T61 9622-9726 Sentence denotes Intraperitoneal (i.p.) injections consisted of 1 ml delivered with a 3 mL syringe and a 23-guage needle.
T15209 9727-9832 Sentence denotes Microchips (BMDS, Seaford, DE) were used to identify and ascertain temperature during ferret experiments.
TextSentencer_T62 9727-9832 Sentence denotes Microchips (BMDS, Seaford, DE) were used to identify and ascertain temperature during ferret experiments.
T63505 9833-9969 Sentence denotes In the first ferret challenge study faulty chips lead to inaccurate temperature readings and were only used for identification purposes.
TextSentencer_T63 9833-9969 Sentence denotes In the first ferret challenge study faulty chips lead to inaccurate temperature readings and were only used for identification purposes.
T13453 9970-10032 Sentence denotes Animals were randomized upon receipt into experimental groups.
TextSentencer_T64 9970-10032 Sentence denotes Animals were randomized upon receipt into experimental groups.
T96484 10033-10226 Sentence denotes Ferrets were socially housed in metal caging, two to a cage, with sight lines to additional animals in the study, in a climate and humidity controlled ABSL-3 with 12/hour light and dark cycles.
TextSentencer_T65 10033-10226 Sentence denotes Ferrets were socially housed in metal caging, two to a cage, with sight lines to additional animals in the study, in a climate and humidity controlled ABSL-3 with 12/hour light and dark cycles.
T43548 10227-10317 Sentence denotes Each cage had a nesting box with bedding material, and numerous tubes and shelfs for play.
TextSentencer_T66 10227-10317 Sentence denotes Each cage had a nesting box with bedding material, and numerous tubes and shelfs for play.
T32868 10318-10435 Sentence denotes Ferrets had access to pelleted food supplemented with treats and potable water, through an automated watering system.
TextSentencer_T67 10318-10435 Sentence denotes Ferrets had access to pelleted food supplemented with treats and potable water, through an automated watering system.
T26608 10436-10519 Sentence denotes Enrichment in the form of manipulada (tubes, balls, mirrors) and food was provided.
TextSentencer_T68 10436-10519 Sentence denotes Enrichment in the form of manipulada (tubes, balls, mirrors) and food was provided.
T58099 10520-10614 Sentence denotes Animals were observed daily by trained personnel in addition to general husbandry assessments.
TextSentencer_T69 10520-10614 Sentence denotes Animals were observed daily by trained personnel in addition to general husbandry assessments.
T23659 10615-10733 Sentence denotes Humane euthanasia criteria, defined as both dyspnea, loss of mobility (to obtain food and water) and >20% weight loss.
TextSentencer_T70 10615-10733 Sentence denotes Humane euthanasia criteria, defined as both dyspnea, loss of mobility (to obtain food and water) and >20% weight loss.
T70725 10734-10907 Sentence denotes At the end of the experiment, terminal blood samples were collected from the heart after administration of KAX and prior to intracardiac injection with pentobarbital sodium.
TextSentencer_T71 10734-10907 Sentence denotes At the end of the experiment, terminal blood samples were collected from the heart after administration of KAX and prior to intracardiac injection with pentobarbital sodium.
T11111 10908-10974 Sentence denotes No pain relief, aside from anesthesia during procedures, was used.
TextSentencer_T72 10908-10974 Sentence denotes No pain relief, aside from anesthesia during procedures, was used.
T40590 10975-11146 Sentence denotes When disease occurs independently in each of four ferrets with 50% probability, the experiment will have odds about 9:1 in favor of producing at least one diseased ferret.
TextSentencer_T73 10975-11146 Sentence denotes When disease occurs independently in each of four ferrets with 50% probability, the experiment will have odds about 9:1 in favor of producing at least one diseased ferret.
T93055 11147-11274 Sentence denotes Conversely failure to observe any diseased ferret in a group of four will yield a 95% confidence interval extending from 0-50%.
TextSentencer_T74 11147-11274 Sentence denotes Conversely failure to observe any diseased ferret in a group of four will yield a 95% confidence interval extending from 0-50%.
T16259 11275-11370 Sentence denotes That is, with 95% confidence it will be admitted that the true disease rate may be 50% or less.
TextSentencer_T75 11275-11370 Sentence denotes That is, with 95% confidence it will be admitted that the true disease rate may be 50% or less.
T11383 11371-11440 Sentence denotes For this reason groups of four ferrets were used for the experiments.
TextSentencer_T76 11371-11440 Sentence denotes For this reason groups of four ferrets were used for the experiments.
T90736 11441-11512 Sentence denotes For each experiment pre-sera from animals served as a negative control.
TextSentencer_T77 11441-11512 Sentence denotes For each experiment pre-sera from animals served as a negative control.
T92730 11513-11651 Sentence denotes Adult marmosets weighing over 300g were anesthetized by inhalation of vaporized isoflurane using an IMPAC 6 veterinary anesthesia machine.
TextSentencer_T78 11513-11651 Sentence denotes Adult marmosets weighing over 300g were anesthetized by inhalation of vaporized isoflurane using an IMPAC 6 veterinary anesthesia machine.
T13491 11652-11750 Sentence denotes Once anesthetized, animals were injected with the indicated concentration of virus diluted in PBS.
TextSentencer_T79 11652-11750 Sentence denotes Once anesthetized, animals were injected with the indicated concentration of virus diluted in PBS.
T36200 11751-11869 Sentence denotes I.m. injections (in the caudal thigh) consisted of 0.2 ml delivered with a 1ml syringe with a 25-gauge, 5/8 in needle.
TextSentencer_T80 11751-11869 Sentence denotes I.m. injections (in the caudal thigh) consisted of 0.2 ml delivered with a 1ml syringe with a 25-gauge, 5/8 in needle.
T35587 11870-12031 Sentence denotes Blood sampling from a femoral vein occurred under previously stated methods of anesthesia, and were limited to 7% of each marmoset's total blood volume per week.
TextSentencer_T81 11870-12031 Sentence denotes Blood sampling from a femoral vein occurred under previously stated methods of anesthesia, and were limited to 7% of each marmoset's total blood volume per week.
T15804 12032-12224 Sentence denotes At time of euthanasia, terminal blood samples were collected from the heart after anesthetization by i.m. injection of Telazol and prior to intracardiac administration of pentobarbital sodium.
TextSentencer_T82 12032-12224 Sentence denotes At time of euthanasia, terminal blood samples were collected from the heart after anesthetization by i.m. injection of Telazol and prior to intracardiac administration of pentobarbital sodium.
T82195 12225-12290 Sentence denotes Animals were housed in containment as previously described [26] .
TextSentencer_T83 12225-12290 Sentence denotes Animals were housed in containment as previously described [26] .
T74542 12291-12411 Sentence denotes In brief, animals were singly housed in metal cages meeting current standards in a climate and humidity controlled room.
TextSentencer_T84 12291-12411 Sentence denotes In brief, animals were singly housed in metal cages meeting current standards in a climate and humidity controlled room.
T32118 12412-12566 Sentence denotes Animals were fed pelleted food supplemented with fruits and treats daily, and were provided potable water through an automatic watering system ad libitum.
TextSentencer_T85 12412-12566 Sentence denotes Animals were fed pelleted food supplemented with fruits and treats daily, and were provided potable water through an automatic watering system ad libitum.
T30341 12567-12688 Sentence denotes Enrichment in the form of manipulada (i.e. toys, metal mirrors), foraging devices, treats, and fruit were provided daily.
TextSentencer_T86 12567-12688 Sentence denotes Enrichment in the form of manipulada (i.e. toys, metal mirrors), foraging devices, treats, and fruit were provided daily.
T1951 12689-12783 Sentence denotes Animals were observed daily by trained personnel in addition to general husbandry assessments.
TextSentencer_T87 12689-12783 Sentence denotes Animals were observed daily by trained personnel in addition to general husbandry assessments.
T10396 12784-12878 Sentence denotes Animals were observed daily by trained personnel in addition to general husbandry assessments.
TextSentencer_T88 12784-12878 Sentence denotes Animals were observed daily by trained personnel in addition to general husbandry assessments.
T36021 12879-13149 Sentence denotes Animals found moribund (defined as labored breathing, decreased food consumption, persistent prostration and moderate unresponsiveness) would be euthanized under humane endpoint criteria, however, as animals did not become ill during the study this criteria was not met.
TextSentencer_T89 12879-13149 Sentence denotes Animals found moribund (defined as labored breathing, decreased food consumption, persistent prostration and moderate unresponsiveness) would be euthanized under humane endpoint criteria, however, as animals did not become ill during the study this criteria was not met.
T85365 13150-13232 Sentence denotes No additional pain relief, aside from anesthesia during procedures, was necessary.
TextSentencer_T90 13150-13232 Sentence denotes No additional pain relief, aside from anesthesia during procedures, was necessary.
T46521 13233-13280 Sentence denotes All work was performed in an ABSL-3 laboratory.
TextSentencer_T91 13233-13280 Sentence denotes All work was performed in an ABSL-3 laboratory.
T32685 13281-13472 Sentence denotes The marmoset study requires a sample size of 3 for adequate power to determine if the incidence of seroconversion is significantly greater than that which would be expected in the population.
TextSentencer_T92 13281-13472 Sentence denotes The marmoset study requires a sample size of 3 for adequate power to determine if the incidence of seroconversion is significantly greater than that which would be expected in the population.
T75220 13473-13698 Sentence denotes This sample size will allow the experimenter to detect seroconversion in at least 2 of 3 animals (66%) versus the expected population constant of <1% at a 95% confidence level using a one-tailed binomial test for proportions.
TextSentencer_T93 13473-13698 Sentence denotes This sample size will allow the experimenter to detect seroconversion in at least 2 of 3 animals (66%) versus the expected population constant of <1% at a 95% confidence level using a one-tailed binomial test for proportions.
T33712 13699-13846 Sentence denotes The enzyme-linked immunosorbent assay (ELISA) used to detect nucleocapsid protein (N) specific antibodies (N-ELISA) was described previously [34] .
TextSentencer_T94 13699-13846 Sentence denotes The enzyme-linked immunosorbent assay (ELISA) used to detect nucleocapsid protein (N) specific antibodies (N-ELISA) was described previously [34] .
T82278 13847-14161 Sentence denotes Species-specific secondary antibodies were used at the following concentrations: peroxide-labeled anti-hamster (1:10,000) (Sera Care, Gaithersburg, MD), peroxide-labeled anti-ferret (1:5,000) (Sigma Aldrich, St. Louis, MO), and alkaline phosphatase conjugated anti-monkey (1:1,000) (MilliporeSigma, St. Louis, MO).
TextSentencer_T95 13847-14161 Sentence denotes Species-specific secondary antibodies were used at the following concentrations: peroxide-labeled anti-hamster (1:10,000) (Sera Care, Gaithersburg, MD), peroxide-labeled anti-ferret (1:5,000) (Sigma Aldrich, St. Louis, MO), and alkaline phosphatase conjugated anti-monkey (1:1,000) (MilliporeSigma, St. Louis, MO).
T70536 14162-14454 Sentence denotes Assays using peroxide labeled antibodies were developed with TMB microwell peroxidase substrate (Sera Care) at an absorbance of 450 nm; assays using alkaline phosphatase conjugated antibodies were developed with p-nitrophenyl phosphate (PNPP) (ThermoFisher Scientific, Waltham, MA) at 405 nm.
TextSentencer_T96 14162-14454 Sentence denotes Assays using peroxide labeled antibodies were developed with TMB microwell peroxidase substrate (Sera Care) at an absorbance of 450 nm; assays using alkaline phosphatase conjugated antibodies were developed with p-nitrophenyl phosphate (PNPP) (ThermoFisher Scientific, Waltham, MA) at 405 nm.
T57920 14455-14679 Sentence denotes A sample was considered positive if its peak optical density (OD) value was greater than either 0.025 or the background value (the average of three negative controls + 3 times their standard deviation), whichever was higher.
TextSentencer_T97 14455-14679 Sentence denotes A sample was considered positive if its peak optical density (OD) value was greater than either 0.025 or the background value (the average of three negative controls + 3 times their standard deviation), whichever was higher.
T33111 14680-14801 Sentence denotes The specific OD sum is the summation of all values greater than background and represents the area under the titer curve.
TextSentencer_T98 14680-14801 Sentence denotes The specific OD sum is the summation of all values greater than background and represents the area under the titer curve.
T10132 14802-14886 Sentence denotes PRNT assays were performed as previously described with minor modifications [35-37].
TextSentencer_T99 14802-14886 Sentence denotes PRNT assays were performed as previously described with minor modifications [35-37].
T29487 14887-15044 Sentence denotes HTNV-infected monolayers were fixed 7 days post-infection, while PUUV-infected monolayers were fixed 10 days post infection by 2 mL of 10% formalin per well.
TextSentencer_T100 14887-15044 Sentence denotes HTNV-infected monolayers were fixed 7 days post-infection, while PUUV-infected monolayers were fixed 10 days post infection by 2 mL of 10% formalin per well.
T51028 15045-15104 Sentence denotes Immunostaining was performed as previously described [38] .
TextSentencer_T101 15045-15104 Sentence denotes Immunostaining was performed as previously described [38] .
T120 15105-15183 Sentence denotes All sera samples were assayed in duplicate beginning at a 1:20 final dilution.
TextSentencer_T102 15105-15183 Sentence denotes All sera samples were assayed in duplicate beginning at a 1:20 final dilution.
T96576 15184-15281 Sentence denotes PRNT 50 values represent the reciprocal dilution at which the serum neutralizes 50% of the virus.
TextSentencer_T103 15184-15281 Sentence denotes PRNT 50 values represent the reciprocal dilution at which the serum neutralizes 50% of the virus.
T74974 15282-15491 Sentence denotes Approximately 200 mg of organ tissue was homogenized in 1.0 mL of TRIzol (ThermoFisher, Waltham, MA) reagent using M tubes on the gentleMACS (Miltenyi Biotec,Auburn, CA) dissociation system on the RNA setting.
TextSentencer_T104 15282-15491 Sentence denotes Approximately 200 mg of organ tissue was homogenized in 1.0 mL of TRIzol (ThermoFisher, Waltham, MA) reagent using M tubes on the gentleMACS (Miltenyi Biotec,Auburn, CA) dissociation system on the RNA setting.
T49844 15492-15550 Sentence denotes RNA was extracted from TRIzol per manufacturer's protocol.
TextSentencer_T105 15492-15550 Sentence denotes RNA was extracted from TRIzol per manufacturer's protocol.
T87053 15551-15710 Sentence denotes A Nanodrop 8000 was used to determined RNA concentration, which was then raised to either 100 ng/μL or 1,000 ng/μL in UltraPure distilled water (Thermofisher).
TextSentencer_T106 15551-15710 Sentence denotes A Nanodrop 8000 was used to determined RNA concentration, which was then raised to either 100 ng/μL or 1,000 ng/μL in UltraPure distilled water (Thermofisher).
T68415 15711-15964 Sentence denotes Real-time PCR was conducted on a BioRad CFX thermal cycler using either an Invitrogen Power SYBR Green RNA-to-Ct one-step kit (Thermofisher) or Brilliant II QRT-PCR 1 -Step Master Mix (Agilent, Santa Clara, CA) according to the manufacturer's protocols.
TextSentencer_T107 15711-15964 Sentence denotes Real-time PCR was conducted on a BioRad CFX thermal cycler using either an Invitrogen Power SYBR Green RNA-to-Ct one-step kit (Thermofisher) or Brilliant II QRT-PCR 1 -Step Master Mix (Agilent, Santa Clara, CA) according to the manufacturer's protocols.
T13931 15965-16077 Sentence denotes For spiked assays the master mix was spiked with either HTNV or PUUV viral RNA prior to addition to the samples.
TextSentencer_T108 15965-16077 Sentence denotes For spiked assays the master mix was spiked with either HTNV or PUUV viral RNA prior to addition to the samples.
T88573 16078-16153 Sentence denotes For HTNV, primer sequences were 594F 5'-AAG CAT GAA GGC AGA AGA GAT -3' and
TextSentencer_T109 16078-16153 Sentence denotes For HTNV, primer sequences were 594F 5'-AAG CAT GAA GGC AGA AGA GAT -3' and
T11870 16155-16272 Sentence denotes T-25 flasks of one week old Vero E6 cells were infected with 50 μL of urine plus an additional 450 μL of cEMEM media.
TextSentencer_T110 16155-16272 Sentence denotes T-25 flasks of one week old Vero E6 cells were infected with 50 μL of urine plus an additional 450 μL of cEMEM media.
T18054 16273-16352 Sentence denotes After a 1 hr adsorption at 37˚C with 5% CO 2 , the volume was raised to 3.5 mL.
TextSentencer_T111 16273-16352 Sentence denotes After a 1 hr adsorption at 37˚C with 5% CO 2 , the volume was raised to 3.5 mL.
T59223 16353-16499 Sentence denotes On Day 4 post infection supernatant was collected and frozen down, 500 μL of which was used to infected fresh Vero E6 cells at a later time point.
TextSentencer_T112 16353-16499 Sentence denotes On Day 4 post infection supernatant was collected and frozen down, 500 μL of which was used to infected fresh Vero E6 cells at a later time point.
T32791 16500-16579 Sentence denotes After a 1 hr adsorption at 37˚C with 5% CO 2 , the volume was raised to 3.5 mL.
TextSentencer_T113 16500-16579 Sentence denotes After a 1 hr adsorption at 37˚C with 5% CO 2 , the volume was raised to 3.5 mL.
T18537 16580-16673 Sentence denotes On days 7, 11, 14, 17, 21 and 28 1.2 mL of culture supernatant was collected and frozen down.
TextSentencer_T114 16580-16673 Sentence denotes On days 7, 11, 14, 17, 21 and 28 1.2 mL of culture supernatant was collected and frozen down.
T16217 16674-16745 Sentence denotes The volume of cEMEM in the flask was raised to 3.5 mL with fresh media.
TextSentencer_T115 16674-16745 Sentence denotes The volume of cEMEM in the flask was raised to 3.5 mL with fresh media.
T93122 16746-16894 Sentence denotes Approximately 200 μg of organ tissue were homogenized in 1 mL of cEMEM media using M tubes on the gentleMACS dissociation system on the RNA setting.
TextSentencer_T116 16746-16894 Sentence denotes Approximately 200 μg of organ tissue were homogenized in 1 mL of cEMEM media using M tubes on the gentleMACS dissociation system on the RNA setting.
T25903 16895-17048 Sentence denotes Plaque assays using urine, sera, or organ homogenate were then performed beginning at the 1:10 dilution as described in [6, 41] with minor modifications.
TextSentencer_T117 16895-17048 Sentence denotes Plaque assays using urine, sera, or organ homogenate were then performed beginning at the 1:10 dilution as described in [6, 41] with minor modifications.
T31522 17049-17237 Sentence denotes For spiked plaque assays the protocol was identical except for equivalent amounts of virus being spiked into either media alone (control), or the 1:10-1:1,000 dilution of organ homogenate.
TextSentencer_T118 17049-17237 Sentence denotes For spiked plaque assays the protocol was identical except for equivalent amounts of virus being spiked into either media alone (control), or the 1:10-1:1,000 dilution of organ homogenate.
T63662 17238-17394 Sentence denotes HTNV-infected monolayers were fixed 7 days postinfection, while PUUV-infected monolayers were fixed 10 days post infection by 2 mL of 10% formalin per well.
TextSentencer_T119 17238-17394 Sentence denotes HTNV-infected monolayers were fixed 7 days postinfection, while PUUV-infected monolayers were fixed 10 days post infection by 2 mL of 10% formalin per well.
T78731 17395-17454 Sentence denotes Immunostaining was performed as previously described [38] .
TextSentencer_T120 17395-17454 Sentence denotes Immunostaining was performed as previously described [38] .
T64851 17455-17503 Sentence denotes Following euthanasia, necropsies were performed.
TextSentencer_T121 17455-17503 Sentence denotes Following euthanasia, necropsies were performed.
T38411 17504-17580 Sentence denotes Samples were collected aseptically for the virology studies described above.
TextSentencer_T122 17504-17580 Sentence denotes Samples were collected aseptically for the virology studies described above.
T26172 17581-17705 Sentence denotes For the hamsters and ferrets, samples of the following were collected: heart, lung, liver, spleen, kidney, brain, and urine.
TextSentencer_T123 17581-17705 Sentence denotes For the hamsters and ferrets, samples of the following were collected: heart, lung, liver, spleen, kidney, brain, and urine.
T88080 17706-17808 Sentence denotes In addition, ferrets had samples of intestine, adrenal gland, pituitary gland, and eye were collected.
TextSentencer_T124 17706-17808 Sentence denotes In addition, ferrets had samples of intestine, adrenal gland, pituitary gland, and eye were collected.
T31980 17809-17926 Sentence denotes Samples of the following were collected from the marmosets: heart, lung, liver, spleen, kidney, intestine, and brain.
TextSentencer_T125 17809-17926 Sentence denotes Samples of the following were collected from the marmosets: heart, lung, liver, spleen, kidney, intestine, and brain.
T21080 17927-18047 Sentence denotes After the virology samples had been collected, all major internal organs in each animal were also sampled for histology.
TextSentencer_T126 17927-18047 Sentence denotes After the virology samples had been collected, all major internal organs in each animal were also sampled for histology.
T23633 18048-18113 Sentence denotes Tissues were fixed in 10% neutral-buffered formalin for �21 days.
TextSentencer_T127 18048-18113 Sentence denotes Tissues were fixed in 10% neutral-buffered formalin for �21 days.
T52092 18114-18236 Sentence denotes Tissues were then trimmed, processed under vacuum through increasing concentrations of alcohols, and embedded in paraffin.
TextSentencer_T128 18114-18236 Sentence denotes Tissues were then trimmed, processed under vacuum through increasing concentrations of alcohols, and embedded in paraffin.
T91229 18237-18431 Sentence denotes Paraffin embedded tissue sections of 5-6 μm were cut and mounted on glass slides, stained with hematoxylin and eosin (H&E), and mounted under a glass coverslip for routine histologic evaluation.
TextSentencer_T129 18237-18431 Sentence denotes Paraffin embedded tissue sections of 5-6 μm were cut and mounted on glass slides, stained with hematoxylin and eosin (H&E), and mounted under a glass coverslip for routine histologic evaluation.
T58433 18432-18588 Sentence denotes The paraffin-embedded tissues used for producing the H&E-stained histology slides were also utilized for immunohistochemistry (IHC) studies in the hamsters.
TextSentencer_T130 18432-18588 Sentence denotes The paraffin-embedded tissues used for producing the H&E-stained histology slides were also utilized for immunohistochemistry (IHC) studies in the hamsters.
T36022 18589-18766 Sentence denotes Immunolocalization of HTNV in tissues was performed with an immunoperoxidase procedure (horseradish peroxidase EnVision system; Dako) according to the manufacturer's directions.
TextSentencer_T131 18589-18766 Sentence denotes Immunolocalization of HTNV in tissues was performed with an immunoperoxidase procedure (horseradish peroxidase EnVision system; Dako) according to the manufacturer's directions.
T24143 18767-18921 Sentence denotes The primary antibody was an anti-HTNV nucleocapsid rabbit polyclonal antibody diluted 1:3,500 (ferret) or 1:5,000 (hamster) (BEI Resources, Manassas, VA).
TextSentencer_T132 18767-18921 Sentence denotes The primary antibody was an anti-HTNV nucleocapsid rabbit polyclonal antibody diluted 1:3,500 (ferret) or 1:5,000 (hamster) (BEI Resources, Manassas, VA).
T91044 18922-19144 Sentence denotes After deparaffinization and peroxidase blocking, tissue sections were pretreated with proteinase K for 6 min at room temperature, rinsed, and then covered with primary antibody and incubated at room temperature for 30 min.
TextSentencer_T133 18922-19144 Sentence denotes After deparaffinization and peroxidase blocking, tissue sections were pretreated with proteinase K for 6 min at room temperature, rinsed, and then covered with primary antibody and incubated at room temperature for 30 min.
T28368 19145-19247 Sentence denotes They were rinsed, and then the peroxidase-labeled polymer (secondary antibody) was applied for 30 min.
TextSentencer_T134 19145-19247 Sentence denotes They were rinsed, and then the peroxidase-labeled polymer (secondary antibody) was applied for 30 min.
T55164 19248-19372 Sentence denotes Slides were rinsed, and a substrate-chromogen solution (3,3'-diaminobenzidine; Dako, Santa Clara, CA) was applied for 5 min.
TextSentencer_T135 19248-19372 Sentence denotes Slides were rinsed, and a substrate-chromogen solution (3,3'-diaminobenzidine; Dako, Santa Clara, CA) was applied for 5 min.
T91403 19373-19489 Sentence denotes The substrate-chromogen solution was rinsed off the slides, and the slides were stained with hematoxylin and rinsed.
TextSentencer_T136 19373-19489 Sentence denotes The substrate-chromogen solution was rinsed off the slides, and the slides were stained with hematoxylin and rinsed.
T51051 19490-19576 Sentence denotes The sections were dehydrated and cleared with xyless, and then a coverslip was placed.
TextSentencer_T137 19490-19576 Sentence denotes The sections were dehydrated and cleared with xyless, and then a coverslip was placed.
T2609 19577-19821 Sentence denotes On the indicated days, anesthetized ferrets were injected i.p. with water soluble Cyp (Baxter Health Care Corporation, Deerfield, IL) with the indicated dosages per body weight of drug diluted in sterile phosphate-buffered saline (PBS), pH 7.4.
TextSentencer_T138 19577-19821 Sentence denotes On the indicated days, anesthetized ferrets were injected i.p. with water soluble Cyp (Baxter Health Care Corporation, Deerfield, IL) with the indicated dosages per body weight of drug diluted in sterile phosphate-buffered saline (PBS), pH 7.4.
T26999 19822-20006 Sentence denotes In the first experiment ferrets were administered a loading dose of 30 mg/kg on Day 41 post infection, with maintenance doses of 30 mg/kg administered every other day until euthanasia.
TextSentencer_T139 19822-20006 Sentence denotes In the first experiment ferrets were administered a loading dose of 30 mg/kg on Day 41 post infection, with maintenance doses of 30 mg/kg administered every other day until euthanasia.
T68539 20007-20156 Sentence denotes In the second experiment, ferrets were administered a loading dose of 30 mg/kg on Day -1, and a maintenance dose of 10 mg/kg on Day 1, 3, 11, and 13.
TextSentencer_T140 20007-20156 Sentence denotes In the second experiment, ferrets were administered a loading dose of 30 mg/kg on Day -1, and a maintenance dose of 10 mg/kg on Day 1, 3, 11, and 13.
T75989 20157-20245 Sentence denotes Administration of Cyp was discontinued between days 3 and 11 due to secondary infection.
TextSentencer_T141 20157-20245 Sentence denotes Administration of Cyp was discontinued between days 3 and 11 due to secondary infection.
T96197 20246-20463 Sentence denotes To combat the infection (rapid onset of fever and weight loss), ferrets were treated with 5mg/kg i.m. enrofloxicin(Norbrook Laboratories, Overland Park, KS) twice daily per veterinarian instructions starting on Day 4.
TextSentencer_T142 20246-20463 Sentence denotes To combat the infection (rapid onset of fever and weight loss), ferrets were treated with 5mg/kg i.m. enrofloxicin(Norbrook Laboratories, Overland Park, KS) twice daily per veterinarian instructions starting on Day 4.
T16969 20464-20607 Sentence denotes Beginning on Day 11 with the resumption of immunosuppression ferrets were treated prophylactically with 10 mg/kg i.m. enrofloxicin once daily).
TextSentencer_T143 20464-20607 Sentence denotes Beginning on Day 11 with the resumption of immunosuppression ferrets were treated prophylactically with 10 mg/kg i.m. enrofloxicin once daily).
T46299 20608-20781 Sentence denotes Blood samples of 0.5 mL were collected in lithium heparin capillary blood collection tubes and analyzed using an Advia 120 hematology analyzer (Software version 3.1.8.0-MS).
TextSentencer_T144 20608-20781 Sentence denotes Blood samples of 0.5 mL were collected in lithium heparin capillary blood collection tubes and analyzed using an Advia 120 hematology analyzer (Software version 3.1.8.0-MS).
T36395 20782-20969 Sentence denotes Per manufacturer's recommendation, the dog setting was used for the complete blood count (CBC) and the guinea pig setting was used for the white blood cell differential (WBC) in hamsters.
TextSentencer_T145 20782-20969 Sentence denotes Per manufacturer's recommendation, the dog setting was used for the complete blood count (CBC) and the guinea pig setting was used for the white blood cell differential (WBC) in hamsters.
T74441 20970-21033 Sentence denotes For ferrets, the dog setting was used for both the CBC and WBC.
TextSentencer_T146 20970-21033 Sentence denotes For ferrets, the dog setting was used for both the CBC and WBC.
T50365 21034-21126 Sentence denotes The PsVNA used to detect neutralizing antibodies in sera was described previously [42, 43] .
TextSentencer_T147 21034-21126 Sentence denotes The PsVNA used to detect neutralizing antibodies in sera was described previously [42, 43] .
T3766 21127-21286 Sentence denotes This is a replication-restricted, recombinant vesicular stomatitis virus (rVSV � ΔG) expressing luciferase, which is pseudotyped with the Hantaan glycoprotein.
TextSentencer_T148 21127-21286 Sentence denotes This is a replication-restricted, recombinant vesicular stomatitis virus (rVSV � ΔG) expressing luciferase, which is pseudotyped with the Hantaan glycoprotein.
T67482 21287-21560 Sentence denotes First, heat-inactivated sera was diluted 1:10, followed by five-fold serial dilutions that were mixed with an equal volume of Eagle 0 s minimum essential medium with Earle 0 s salts and 10% fetal bovine sera containing 4000 fluorescent focus units of Hantaan pseudovirions.
TextSentencer_T149 21287-21560 Sentence denotes First, heat-inactivated sera was diluted 1:10, followed by five-fold serial dilutions that were mixed with an equal volume of Eagle 0 s minimum essential medium with Earle 0 s salts and 10% fetal bovine sera containing 4000 fluorescent focus units of Hantaan pseudovirions.
T62528 21561-21605 Sentence denotes This mixture was incubated overnight at 4˚C.
TextSentencer_T150 21561-21605 Sentence denotes This mixture was incubated overnight at 4˚C.
T26527 21606-21739 Sentence denotes Following this incubation, 50 μl was inoculated onto Vero cell monolayers in a clear bottom, black-walled 96-well plate in duplicate.
TextSentencer_T151 21606-21739 Sentence denotes Following this incubation, 50 μl was inoculated onto Vero cell monolayers in a clear bottom, black-walled 96-well plate in duplicate.
T47348 21740-21783 Sentence denotes Plates were incubated at 37˚C for 18-24 hr.
TextSentencer_T152 21740-21783 Sentence denotes Plates were incubated at 37˚C for 18-24 hr.
T58369 21784-21893 Sentence denotes The media was discarded and cells were lysed according to the luciferase kit protocol (Promega, Madison, WI).
TextSentencer_T153 21784-21893 Sentence denotes The media was discarded and cells were lysed according to the luciferase kit protocol (Promega, Madison, WI).
T42496 21894-21947 Sentence denotes A Tecan M200 Pro was used to acquire luciferase data.
TextSentencer_T154 21894-21947 Sentence denotes A Tecan M200 Pro was used to acquire luciferase data.
T86197 21948-22153 Sentence denotes The values were graphed using GraphPad Prism (version 7) and used to calculate the percent neutralization normalized to cells alone and pseudovirions alone as the minimum and maximum signals, respectively.
TextSentencer_T155 21948-22153 Sentence denotes The values were graphed using GraphPad Prism (version 7) and used to calculate the percent neutralization normalized to cells alone and pseudovirions alone as the minimum and maximum signals, respectively.
T85024 22154-22232 Sentence denotes The percent neutralization values for duplicate serial dilutions were plotted.
TextSentencer_T156 22154-22232 Sentence denotes The percent neutralization values for duplicate serial dilutions were plotted.
T60575 22233-22357 Sentence denotes Fifty percent PsVNA (PsVNA 50 ) titers were interpolated from 4-parameter curves, and geometric mean titers were calculated.
TextSentencer_T157 22233-22357 Sentence denotes Fifty percent PsVNA (PsVNA 50 ) titers were interpolated from 4-parameter curves, and geometric mean titers were calculated.
T21930 22358-22438 Sentence denotes Blood was collected in serum separator tube, and spun at 500x g to isolate sera.
TextSentencer_T158 22358-22438 Sentence denotes Blood was collected in serum separator tube, and spun at 500x g to isolate sera.
T10514 22439-22659 Sentence denotes Ferret sera was analyzed on the Piccolo comprehensive metabolic panel, and marmoset sera was analyzed on the Piccolo general chemistry 13 panel per manufacturer's instructions (Abaxis Global Diagnostics, Union City, CA).
TextSentencer_T159 22439-22659 Sentence denotes Ferret sera was analyzed on the Piccolo comprehensive metabolic panel, and marmoset sera was analyzed on the Piccolo general chemistry 13 panel per manufacturer's instructions (Abaxis Global Diagnostics, Union City, CA).
T44596 22660-22765 Sentence denotes Urine was expressed from anesthetized ferrets and analyzed by urinalysis regent strips (VWR, Radnor, PA).
TextSentencer_T160 22660-22765 Sentence denotes Urine was expressed from anesthetized ferrets and analyzed by urinalysis regent strips (VWR, Radnor, PA).
T5430 22766-22897 Sentence denotes A Bayesian probit model was used to estimate 95% highest posterior density intervals for a 50% and 95% infectious dose calculation.
TextSentencer_T161 22766-22897 Sentence denotes A Bayesian probit model was used to estimate 95% highest posterior density intervals for a 50% and 95% infectious dose calculation.
T59845 22898-23015 Sentence denotes Student's t-test and Mann-Whitney tests were used to compare white blood cell levels pre-and post-Cyp administration.
TextSentencer_T162 22898-23015 Sentence denotes Student's t-test and Mann-Whitney tests were used to compare white blood cell levels pre-and post-Cyp administration.
T41780 23016-23062 Sentence denotes P-values of <0.05 were considered significant.
TextSentencer_T163 23016-23062 Sentence denotes P-values of <0.05 were considered significant.
T52463 23063-23176 Sentence denotes Standard deviation of data was assessed to ensure data was normally distributed prior to use of Student's t-test.
TextSentencer_T164 23063-23176 Sentence denotes Standard deviation of data was assessed to ensure data was normally distributed prior to use of Student's t-test.
T61522 23177-23278 Sentence denotes Analyses were conducted using GraphPad Prism (version 7); Bayesian analyses were performed using SAS.
TextSentencer_T165 23177-23278 Sentence denotes Analyses were conducted using GraphPad Prism (version 7); Bayesian analyses were performed using SAS.
T81450 23279-23450 Sentence denotes We have previously demonstrated that Syrian hamsters are capable of being infected by HFRScausing hantaviruses, but they do not develop any signs of clinical disease [9] .
TextSentencer_T166 23279-23450 Sentence denotes We have previously demonstrated that Syrian hamsters are capable of being infected by HFRScausing hantaviruses, but they do not develop any signs of clinical disease [9] .
T64743 23451-23751 Sentence denotes To develop standard models of HTNV and PUUV infection for future evaluation of vaccines and medical countermeasures, groups of between 10 and 20 hamsters were exposed to serial ten-fold dilutions of either HTNV or PUUV by either the i.m. or i.n. route (from 2-20,000 PFU HTNV or 0.2-20,000 PFU PUUV).
TextSentencer_T167 23451-23751 Sentence denotes To develop standard models of HTNV and PUUV infection for future evaluation of vaccines and medical countermeasures, groups of between 10 and 20 hamsters were exposed to serial ten-fold dilutions of either HTNV or PUUV by either the i.m. or i.n. route (from 2-20,000 PFU HTNV or 0.2-20,000 PFU PUUV).
T94960 23752-23876 Sentence denotes Between 28-35 days post infection, hamsters were terminally bled with infection status monitored by N-ELISA titers (Fig 1) .
TextSentencer_T168 23752-23876 Sentence denotes Between 28-35 days post infection, hamsters were terminally bled with infection status monitored by N-ELISA titers (Fig 1) .
T91317 23877-23980 Sentence denotes From these data the doses required to infect 50% (ID 50 ) and 99% (ID 99 ) were calculated ( Table 1 ).
TextSentencer_T169 23877-23980 Sentence denotes From these data the doses required to infect 50% (ID 50 ) and 99% (ID 99 ) were calculated ( Table 1 ).
T26859 23981-24126 Sentence denotes To further characterize a low-dose standard hamster infection model for HFRS-causing hantaviruses a hamster serial sacrifice study was performed.
TextSentencer_T170 23981-24126 Sentence denotes To further characterize a low-dose standard hamster infection model for HFRS-causing hantaviruses a hamster serial sacrifice study was performed.
T54567 24127-24296 Sentence denotes Hamsters were challenged with either 10 PFU (~3 ID 99 ) HTNV i.m., 500 PFU (~1.5 ID 99 ) HTNV i.n., 1,000 PFU (~1 ID 99 ) PUUV i.m., or 1,000 PFU (~1.5 ID 99 ) PUUV i.n.
TextSentencer_T171 24127-24296 Sentence denotes Hamsters were challenged with either 10 PFU (~3 ID 99 ) HTNV i.m., 500 PFU (~1.5 ID 99 ) HTNV i.n., 1,000 PFU (~1 ID 99 ) PUUV i.m., or 1,000 PFU (~1.5 ID 99 ) PUUV i.n.
T30571 24297-24414 Sentence denotes On various days post infection, groups of three hamsters were euthanized to monitor viral and serological parameters.
TextSentencer_T172 24297-24414 Sentence denotes On various days post infection, groups of three hamsters were euthanized to monitor viral and serological parameters.
T79000 24415-24521 Sentence denotes Seroconversion occurred, at least partially, by Day 17 post HTNV infection and Day 24 post PUUV infection.
TextSentencer_T173 24415-24521 Sentence denotes Seroconversion occurred, at least partially, by Day 17 post HTNV infection and Day 24 post PUUV infection.
T66632 24522-24717 Sentence denotes Seroconversion on Day 28 post HTNV i.m. infection was incomplete, though viral genome was recovered from all hamsters euthanized that day indicating a productive HTNV infection occurred (Fig 2) .
TextSentencer_T174 24522-24717 Sentence denotes Seroconversion on Day 28 post HTNV i.m. infection was incomplete, though viral genome was recovered from all hamsters euthanized that day indicating a productive HTNV infection occurred (Fig 2) .
T40420 24718-24885 Sentence denotes To confirm seroconversion, all hamsters euthanized on days 17, 24, and 28 were assayed for neutralizing antibodies by PRNT regardless of N-ELISA seroconversion status.
TextSentencer_T175 24718-24885 Sentence denotes To confirm seroconversion, all hamsters euthanized on days 17, 24, and 28 were assayed for neutralizing antibodies by PRNT regardless of N-ELISA seroconversion status.
T16389 24886-25086 Sentence denotes All HTNV infected hamsters with N-ELISA titers had neutralizing antibodies as measured by PRNT 50 , with all but one having full neutralization of virus at a 1:20 dilution of sera. (S1A and S1B Fig) .
TextSentencer_T176 24886-25086 Sentence denotes All HTNV infected hamsters with N-ELISA titers had neutralizing antibodies as measured by PRNT 50 , with all but one having full neutralization of virus at a 1:20 dilution of sera. (S1A and S1B Fig) .
T78873 25087-25340 Sentence denotes Similarly, all PUUV hamsters with N-ELISA titers had neutralizing antibodies as measured by PRNT 50 , though three of the five PUUV i.n. challenged hamsters did not have complete neutralization of the virus at a 1:20 dilution of sera (S1C and S1D Fig) .
TextSentencer_T177 25087-25340 Sentence denotes Similarly, all PUUV hamsters with N-ELISA titers had neutralizing antibodies as measured by PRNT 50 , though three of the five PUUV i.n. challenged hamsters did not have complete neutralization of the virus at a 1:20 dilution of sera (S1C and S1D Fig) .
T32702 25341-25589 Sentence denotes Two of three PUUV i.m. challenged hamsters that had not seroconverted on Day 17 post infection had low levels of neutralizing antibodies, while none of the PUUV i.n. challenged hamsters that were seronegative by N-ELISA had neutralizing antibodies.
TextSentencer_T178 25341-25589 Sentence denotes Two of three PUUV i.m. challenged hamsters that had not seroconverted on Day 17 post infection had low levels of neutralizing antibodies, while none of the PUUV i.n. challenged hamsters that were seronegative by N-ELISA had neutralizing antibodies.
T1243 25590-25734 Sentence denotes For both HTNV and PUUV infected hamsters, infection via the i.m. route lead to a more robust neutralizing antibody response than then i.n.route.
TextSentencer_T179 25590-25734 Sentence denotes For both HTNV and PUUV infected hamsters, infection via the i.m. route lead to a more robust neutralizing antibody response than then i.n.route.
T38836 25735-25891 Sentence denotes The kinetics of HTNV and PUUV infection in the heart, lung, liver, spleen, kidney, and brain were monitored by both RT-PCR and plaque assay (Figs 3 and 4) .
TextSentencer_T180 25735-25891 Sentence denotes The kinetics of HTNV and PUUV infection in the heart, lung, liver, spleen, kidney, and brain were monitored by both RT-PCR and plaque assay (Figs 3 and 4) .
T26236 25892-25974 Sentence denotes HTNV infected by either the i.m. or i.n. route resulted in a persistent infection.
TextSentencer_T181 25892-25974 Sentence denotes HTNV infected by either the i.m. or i.n. route resulted in a persistent infection.
T24478 25975-26153 Sentence denotes High levels of viral genome were detected in the heart, lung, kidney and brain of HTNV infected hamsters beginning on either Day 11 or 17 post infection (Fig 3A, 3B , 3E and 3F).
TextSentencer_T182 25975-26153 Sentence denotes High levels of viral genome were detected in the heart, lung, kidney and brain of HTNV infected hamsters beginning on either Day 11 or 17 post infection (Fig 3A, 3B , 3E and 3F).
T24501 26154-26401 Sentence denotes Infection of the kidney and brain was found in all examined hamsters beginning on either Day 17 or 24 post infection, while the high titers of viral genome detected in the heart and lung were present in only one or two hamsters at each time point.
TextSentencer_T183 26154-26401 Sentence denotes Infection of the kidney and brain was found in all examined hamsters beginning on either Day 17 or 24 post infection, while the high titers of viral genome detected in the heart and lung were present in only one or two hamsters at each time point.
T23505 26402-26548 Sentence denotes Low levels of viral genome were detected between days 11 and 24 post infection in the liver of HTNV i.m. but not i.n. infected hamsters (Fig 3C) .
TextSentencer_T184 26402-26548 Sentence denotes Low levels of viral genome were detected between days 11 and 24 post infection in the liver of HTNV i.m. but not i.n. infected hamsters (Fig 3C) .
T13066 26549-26610 Sentence denotes Hardly any viral genome was detected in the spleen (Fig 3D) .
TextSentencer_T185 26549-26610 Sentence denotes Hardly any viral genome was detected in the spleen (Fig 3D) .
T86480 26611-26797 Sentence denotes To confirm the lack of viral genome in the spleen was not due to the presence of inhibitors all spleen samples from i.m. and i.n. infected hamsters were spiked with HTNV prior to RT-PCR.
TextSentencer_T186 26611-26797 Sentence denotes To confirm the lack of viral genome in the spleen was not due to the presence of inhibitors all spleen samples from i.m. and i.n. infected hamsters were spiked with HTNV prior to RT-PCR.
T6640 26798-26956 Sentence denotes No significant inhibition of the spiked RNA was noted, indicating that HTNV infection does not result in virus dissemination to the spleen (S2A and S2B Fig) .
TextSentencer_T187 26798-26956 Sentence denotes No significant inhibition of the spiked RNA was noted, indicating that HTNV infection does not result in virus dissemination to the spleen (S2A and S2B Fig) .
T21810 26957-27155 Sentence denotes The detection of PUUV in organs was transient after i.m. infection, occurring between Day 11-17 for the heart, liver, kidney and brain, with no virus detected in the spleen (Fig 3A, 3C , 3E and 3F).
TextSentencer_T188 26957-27155 Sentence denotes The detection of PUUV in organs was transient after i.m. infection, occurring between Day 11-17 for the heart, liver, kidney and brain, with no virus detected in the spleen (Fig 3A, 3C , 3E and 3F).
T96930 27156-27298 Sentence denotes Viral genome was more persistent in the lung where it was detected in at least one of three hamsters on/after Day 11 post infection (Fig 3B) .
TextSentencer_T189 27156-27298 Sentence denotes Viral genome was more persistent in the lung where it was detected in at least one of three hamsters on/after Day 11 post infection (Fig 3B) .
T90460 27299-27509 Sentence denotes A small amount of viral genome detected in the brain of a PUUV i.n. infected hamster, 28 days post challenge, is the only viral genome detected in any organ at any time point post PUUV i.n. infection (Fig 3F) .
TextSentencer_T190 27299-27509 Sentence denotes A small amount of viral genome detected in the brain of a PUUV i.n. infected hamster, 28 days post challenge, is the only viral genome detected in any organ at any time point post PUUV i.n. infection (Fig 3F) .
T37320 27510-27674 Sentence denotes Serum viremia was detected in hamsters challenged with HTNV i.m. between 11 and 28 days post infection, though the presence of virus was sporadic except for Day 24.
TextSentencer_T191 27510-27674 Sentence denotes Serum viremia was detected in hamsters challenged with HTNV i.m. between 11 and 28 days post infection, though the presence of virus was sporadic except for Day 24.
T42942 27675-27782 Sentence denotes Serum viremia was only detected in two hamsters challenged with HTNV i.n., one on Day 11 and one on Day 17.
TextSentencer_T192 27675-27782 Sentence denotes Serum viremia was only detected in two hamsters challenged with HTNV i.n., one on Day 11 and one on Day 17.
T64625 27783-27872 Sentence denotes No serum viremia was detected in hamsters challenged with PUUV by either route (Fig 3G) .
TextSentencer_T193 27783-27872 Sentence denotes No serum viremia was detected in hamsters challenged with PUUV by either route (Fig 3G) .
T33515 27873-28108 Sentence denotes Similarly, the presence of viral genome was sporadically detected in the urine of Three HFRS-associated hantavirus infection models HTNV infected hamsters between days 17-28, but was not detected in PUUV challenged hamsters ( Fig 3H) .
TextSentencer_T194 27873-28108 Sentence denotes Similarly, the presence of viral genome was sporadically detected in the urine of Three HFRS-associated hantavirus infection models HTNV infected hamsters between days 17-28, but was not detected in PUUV challenged hamsters ( Fig 3H) .
T76003 28109-28303 Sentence denotes In HTNV i.m. infected hamsters, infectious virus was first detected in the liver beginning at Day 11, and in the lung, liver, spleen, and kidney at Day 17 post infection (Fig 4B, 4C, 4D and 4E).
TextSentencer_T195 28109-28303 Sentence denotes In HTNV i.m. infected hamsters, infectious virus was first detected in the liver beginning at Day 11, and in the lung, liver, spleen, and kidney at Day 17 post infection (Fig 4B, 4C, 4D and 4E).
T87414 28304-28546 Sentence denotes With the exception of the kidney, in which infectious virus was recovered from every hamster after 17 days post infection, infectious virus was recovered from the lung, liver, brain and spleen in only a portion of hamsters at each time point.
TextSentencer_T196 28304-28546 Sentence denotes With the exception of the kidney, in which infectious virus was recovered from every hamster after 17 days post infection, infectious virus was recovered from the lung, liver, brain and spleen in only a portion of hamsters at each time point.
T42592 28547-28621 Sentence denotes No infectious virus was detected in the heart at any time point (Fig 4A) .
TextSentencer_T197 28547-28621 Sentence denotes No infectious virus was detected in the heart at any time point (Fig 4A) .
T8649 28622-28837 Sentence denotes Virus recovery from HTNV i.n. infected hamsters was markedly lower, with infectious virus being detected only in the kidney on Day17 and 28 post Three HFRS-associated hantavirus infection models infection (Fig 4E) .
TextSentencer_T198 28622-28837 Sentence denotes Virus recovery from HTNV i.n. infected hamsters was markedly lower, with infectious virus being detected only in the kidney on Day17 and 28 post Three HFRS-associated hantavirus infection models infection (Fig 4E) .
T37450 28838-28925 Sentence denotes No infectious virus was recovered from the organ of any PUUV infected hamster (Fig 4) .
TextSentencer_T199 28838-28925 Sentence denotes No infectious virus was recovered from the organ of any PUUV infected hamster (Fig 4) .
T27948 28926-29094 Sentence denotes To confirm that the lack of infectious virus in the spleen was not due to the presence of inhibitors select samples were spiked with HTNV virus prior to a plaque assay.
TextSentencer_T200 28926-29094 Sentence denotes To confirm that the lack of infectious virus in the spleen was not due to the presence of inhibitors select samples were spiked with HTNV virus prior to a plaque assay.
T25228 29095-29277 Sentence denotes No significant inhibition of the spiked RNA was noted, confirming the RT-PCR results that that HTNV infection does not result in viral dissemination to the spleen (S2C and S2D Fig) .
TextSentencer_T201 29095-29277 Sentence denotes No significant inhibition of the spiked RNA was noted, confirming the RT-PCR results that that HTNV infection does not result in viral dissemination to the spleen (S2C and S2D Fig) .
T72556 29278-29407 Sentence denotes No infectious virus was detected in the urine for any hamster tested, even those that were RT-PCR positive for HTNV viral genome.
TextSentencer_T202 29278-29407 Sentence denotes No infectious virus was detected in the urine for any hamster tested, even those that were RT-PCR positive for HTNV viral genome.
T46451 29408-29599 Sentence denotes In human ANDV infected patients with ANDV antigen positive urine, samples had to be cultured in Vero E6 cells for between 16-22 days post infection before infectious virus was detected [44] .
TextSentencer_T203 29408-29599 Sentence denotes In human ANDV infected patients with ANDV antigen positive urine, samples had to be cultured in Vero E6 cells for between 16-22 days post infection before infectious virus was detected [44] .
T97652 29600-29710 Sentence denotes Patients infected with HFRS hantaviruses exhibit leukocytosis and thrombocytopenia during infection [45, 46] .
TextSentencer_T204 29600-29710 Sentence denotes Patients infected with HFRS hantaviruses exhibit leukocytosis and thrombocytopenia during infection [45, 46] .
T75040 29711-29894 Sentence denotes At every time point post infection, EDTA-treated whole blood from HTNV and PUUV exposed hamsters was evaluated to determine if changes in white blood cell count or platelets occurred.
TextSentencer_T205 29711-29894 Sentence denotes At every time point post infection, EDTA-treated whole blood from HTNV and PUUV exposed hamsters was evaluated to determine if changes in white blood cell count or platelets occurred.
T91786 29895-29929 Sentence denotes No changes were observed (S4 Fig).
TextSentencer_T206 29895-29929 Sentence denotes No changes were observed (S4 Fig).
T16672 29930-30106 Sentence denotes To further characterize disease, tissue sections from HTNV i.m. infected hamsters were analyzed by IHC and H&E to assess viral localization and any pathologic changes (S5 Fig).
TextSentencer_T207 29930-30106 Sentence denotes To further characterize disease, tissue sections from HTNV i.m. infected hamsters were analyzed by IHC and H&E to assess viral localization and any pathologic changes (S5 Fig).
T72662 30107-30183 Sentence denotes No significant histopathological findings were noted in the kidney or brain.
TextSentencer_T208 30107-30183 Sentence denotes No significant histopathological findings were noted in the kidney or brain.
T44213 30184-30312 Sentence denotes Splenic follicular lymphoid hyperplasia and hepatic extramedullary hematopoiesis in the liver were each noted in three hamsters.
TextSentencer_T209 30184-30312 Sentence denotes Splenic follicular lymphoid hyperplasia and hepatic extramedullary hematopoiesis in the liver were each noted in three hamsters.
T8830 30313-30502 Sentence denotes Both are seen in animals from later time points in the study (days 17-28) and likely represent a reaction to HTNV infection, though other unidentified antigenic stimuli cannot be ruled out.
TextSentencer_T210 30313-30502 Sentence denotes Both are seen in animals from later time points in the study (days 17-28) and likely represent a reaction to HTNV infection, though other unidentified antigenic stimuli cannot be ruled out.
T19748 30503-30698 Sentence denotes Five hamsters between days 4 and 17 post infection exhibited a minimal to mild inflammation of the pericardium, characterized by a mixed lymphoplasmacytic histiocytic and neutrophilic infiltrate.
TextSentencer_T211 30503-30698 Sentence denotes Five hamsters between days 4 and 17 post infection exhibited a minimal to mild inflammation of the pericardium, characterized by a mixed lymphoplasmacytic histiocytic and neutrophilic infiltrate.
T48006 30699-30934 Sentence denotes Occasional macrophages in the inflammatory infiltrate within the pericardium are immunopositive suggesting a possible association with HTNV; however, no evidence of cardiac tissue injury is associated with the presence of HTNV antigen.
TextSentencer_T212 30699-30934 Sentence denotes Occasional macrophages in the inflammatory infiltrate within the pericardium are immunopositive suggesting a possible association with HTNV; however, no evidence of cardiac tissue injury is associated with the presence of HTNV antigen.
T2152 30935-31195 Sentence denotes Beginning on Day 4 post infection 66% (12/18) hamsters exhibit minimal (likely subclinical) respiratory lesions consisting of interstitial neutrophilic and histiocytic infiltrates in the lungs, with 44% (8/18) also exhibiting minimal amounts of alveolar edema.
TextSentencer_T213 30935-31195 Sentence denotes Beginning on Day 4 post infection 66% (12/18) hamsters exhibit minimal (likely subclinical) respiratory lesions consisting of interstitial neutrophilic and histiocytic infiltrates in the lungs, with 44% (8/18) also exhibiting minimal amounts of alveolar edema.
T69979 31196-31275 Sentence denotes An additional hamster had minimal alveolar edema but not pulmonary infiltrates.
TextSentencer_T214 31196-31275 Sentence denotes An additional hamster had minimal alveolar edema but not pulmonary infiltrates.
T2122 31276-31459 Sentence denotes Such findings suggest a response to antigenic stimulus and the presence of immunopositive endothelial cells, pneumocytes and alveolar macrophages suggest a response to HTNV infection.
TextSentencer_T215 31276-31459 Sentence denotes Such findings suggest a response to antigenic stimulus and the presence of immunopositive endothelial cells, pneumocytes and alveolar macrophages suggest a response to HTNV infection.
T51217 31460-31552 Sentence denotes Immunohistochemistry staining was uniformly negative in all tissues on Day 1 post challenge.
TextSentencer_T216 31460-31552 Sentence denotes Immunohistochemistry staining was uniformly negative in all tissues on Day 1 post challenge.
T93060 31553-31681 Sentence denotes Between Day 4 and 11 post challenge minimal antigen was sporadically detected in macrophages, pneumocytes and endothelial cells.
TextSentencer_T217 31553-31681 Sentence denotes Between Day 4 and 11 post challenge minimal antigen was sporadically detected in macrophages, pneumocytes and endothelial cells.
T14149 31682-31918 Sentence denotes By Day 17 post challenge mild to moderate levels of antigen were observed in endothelial cells and choroid ependymal cells in the brain, in endothelial cells, macrophages and pneumocytes in the lung, and endothelial cells in the kidney.
TextSentencer_T218 31682-31918 Sentence denotes By Day 17 post challenge mild to moderate levels of antigen were observed in endothelial cells and choroid ependymal cells in the brain, in endothelial cells, macrophages and pneumocytes in the lung, and endothelial cells in the kidney.
T30309 31919-32093 Sentence denotes Minimal to mild levels of immunopositivity were found in endothelial cells and macrophages in the heart, and in endothelial cells, hepatocytes and Kupffer cells in the liver.
TextSentencer_T219 31919-32093 Sentence denotes Minimal to mild levels of immunopositivity were found in endothelial cells and macrophages in the heart, and in endothelial cells, hepatocytes and Kupffer cells in the liver.
T9416 32094-32296 Sentence denotes Surprisingly, given the lack of viral genome and infectious virus recovered, mild to moderate amounts of immunopositive macrophages, lymphocytes and endothelial cells were found in the spleen ( Table 2,
TextSentencer_T220 32094-32296 Sentence denotes Surprisingly, given the lack of viral genome and infectious virus recovered, mild to moderate amounts of immunopositive macrophages, lymphocytes and endothelial cells were found in the spleen ( Table 2,
T42745 32298-32377 Sentence denotes No published studies detail if ferrets are susceptible to hantavirus infection.
TextSentencer_T221 32298-32377 Sentence denotes No published studies detail if ferrets are susceptible to hantavirus infection.
T45105 32378-32462 Sentence denotes To examine this, four ferrets were exposed to either 2,000 PFU HTNV or PUUV K27 i.n.
TextSentencer_T222 32378-32462 Sentence denotes To examine this, four ferrets were exposed to either 2,000 PFU HTNV or PUUV K27 i.n.
T29076 32463-32520 Sentence denotes No seroconversion occurred within 35 days post infection.
TextSentencer_T223 32463-32520 Sentence denotes No seroconversion occurred within 35 days post infection.
T92249 32521-32689 Sentence denotes The same animals were re-exposed to either 200,000 PFU HTNV, 94,000 PFU PUUV Beaumont (a human PUUV isolate) or 164,000 PFU PUUV Seloignes (a vole PUUV isolate) by i.m.
TextSentencer_T224 32521-32689 Sentence denotes The same animals were re-exposed to either 200,000 PFU HTNV, 94,000 PFU PUUV Beaumont (a human PUUV isolate) or 164,000 PFU PUUV Seloignes (a vole PUUV isolate) by i.m.
T84568 32690-32950 Sentence denotes Prior to the re-exposure one of the seronegative ferrets in the HTNV group was removed for health concerns (rapid weight loss) unrelated to the study, and it's cage mate was subsequently removed for behavioral health reasons before the completion of the study.
TextSentencer_T225 32690-32950 Sentence denotes Prior to the re-exposure one of the seronegative ferrets in the HTNV group was removed for health concerns (rapid weight loss) unrelated to the study, and it's cage mate was subsequently removed for behavioral health reasons before the completion of the study.
T71534 32951-32993 Sentence denotes Data from those two ferrets are not shown.
TextSentencer_T226 32951-32993 Sentence denotes Data from those two ferrets are not shown.
T34454 32994-33170 Sentence denotes As soon as three days post infection ferrets began to lose weight with HTNV infected ferrets losing between 5-12% of peak body weight as did PUUV infected ferrets (Fig 5A-5C ).
TextSentencer_T227 32994-33170 Sentence denotes As soon as three days post infection ferrets began to lose weight with HTNV infected ferrets losing between 5-12% of peak body weight as did PUUV infected ferrets (Fig 5A-5C ).
T78171 33171-33308 Sentence denotes By Day 35 post infection all animals had developed antibodies against all strains of the virus as measured by N-ELISA assay (Fig 5D-5F ).
TextSentencer_T228 33171-33308 Sentence denotes By Day 35 post infection all animals had developed antibodies against all strains of the virus as measured by N-ELISA assay (Fig 5D-5F ).
T70835 33309-33471 Sentence denotes Neutralizing antibody development began as early as Day 14 post infection and all ferrets developed neutralizing antibodies by Day 28 post infection (Fig 5G-5L) .
TextSentencer_T229 33309-33471 Sentence denotes Neutralizing antibody development began as early as Day 14 post infection and all ferrets developed neutralizing antibodies by Day 28 post infection (Fig 5G-5L) .
T22966 33472-33604 Sentence denotes EDTA The organs of infected ferrets were analyzed for viral load by RT-PCR and for the presence of infectious virus by plaque assay.
TextSentencer_T230 33472-33604 Sentence denotes EDTA The organs of infected ferrets were analyzed for viral load by RT-PCR and for the presence of infectious virus by plaque assay.
T48676 33605-33801 Sentence denotes The lung, liver, spleen, intestine and urine of HTNV infected ferrets were negative for viral genome, with small amounts (<2 log 10 ) detected in the heart and spleen of a single animal (S7B Fig).
TextSentencer_T231 33605-33801 Sentence denotes The lung, liver, spleen, intestine and urine of HTNV infected ferrets were negative for viral genome, with small amounts (<2 log 10 ) detected in the heart and spleen of a single animal (S7B Fig).
T93004 33802-34019 Sentence denotes The heart, lung, kidney, intestine and urine of PUUV infected ferrets were negative for viral genome, though small amounts were detected in the liver (2/4) and spleen (1/4) of PUUV infected ferrets (S7C and S7D Fig) .
TextSentencer_T232 33802-34019 Sentence denotes The heart, lung, kidney, intestine and urine of PUUV infected ferrets were negative for viral genome, though small amounts were detected in the liver (2/4) and spleen (1/4) of PUUV infected ferrets (S7C and S7D Fig) .
T17303 34020-34136 Sentence denotes Viral genome was spiked into the assay to confirm that the lack of signal was not due to the presence of inhibitors.
TextSentencer_T233 34020-34136 Sentence denotes Viral genome was spiked into the assay to confirm that the lack of signal was not due to the presence of inhibitors.
T33765 34137-34215 Sentence denotes All organs except for the intestine (4/6) had no inhibition of RT-PCR product.
TextSentencer_T234 34137-34215 Sentence denotes All organs except for the intestine (4/6) had no inhibition of RT-PCR product.
T88780 34216-34371 Sentence denotes Similarly, no infectious virus was found in the organ of any ferret by plaque assay, despite spiked-in virus exhibiting no significant inhibition (S9 Fig).
TextSentencer_T235 34216-34371 Sentence denotes Similarly, no infectious virus was found in the organ of any ferret by plaque assay, despite spiked-in virus exhibiting no significant inhibition (S9 Fig).
T85466 34372-34614 Sentence denotes To confirm that immunosuppression of uninfected ferrets did not result in rapid weight loss, four healthy ferrets were immunosuppressed with a loading dose of 30 mg/kg Cyp followed by 10 mg/kg Cyp maintenance doses every other day (S10A Fig).
TextSentencer_T236 34372-34614 Sentence denotes To confirm that immunosuppression of uninfected ferrets did not result in rapid weight loss, four healthy ferrets were immunosuppressed with a loading dose of 30 mg/kg Cyp followed by 10 mg/kg Cyp maintenance doses every other day (S10A Fig).
T99990 34615-34751 Sentence denotes Five days post immunosuppression ferrets exhibited rapid weight loss, fever, and lethargy due to secondary infection (S10B & S10C Fig) .
TextSentencer_T237 34615-34751 Sentence denotes Five days post immunosuppression ferrets exhibited rapid weight loss, fever, and lethargy due to secondary infection (S10B & S10C Fig) .
T7841 34752-34874 Sentence denotes Immunosupression was discontinued and 5 mg/kg enrofloxicin (a broad spectrum antibiotic) was given twice daily for a week.
TextSentencer_T238 34752-34874 Sentence denotes Immunosupression was discontinued and 5 mg/kg enrofloxicin (a broad spectrum antibiotic) was given twice daily for a week.
T13223 34875-34949 Sentence denotes During this time, ferrets began to gain weight and their fever diminished.
TextSentencer_T239 34875-34949 Sentence denotes During this time, ferrets began to gain weight and their fever diminished.
T73104 34950-35047 Sentence denotes On Day 11 immunosupression resumed for two doses with prophylactic enrofloxicin given once daily.
TextSentencer_T240 34950-35047 Sentence denotes On Day 11 immunosupression resumed for two doses with prophylactic enrofloxicin given once daily.
T30143 35048-35232 Sentence denotes Even with prophylactic antibiotics two ferrets spiked fevers within a few days post the second round of immunosuppressive treatment, though they did not lose weight (S10B & S10C Fig) .
TextSentencer_T241 35048-35232 Sentence denotes Even with prophylactic antibiotics two ferrets spiked fevers within a few days post the second round of immunosuppressive treatment, though they did not lose weight (S10B & S10C Fig) .
T65204 35233-35406 Sentence denotes Based on these results the rapid weight loss and clinical signs observed upon immunosuppression of HTNV and PUUV infected ferrets was most likely due to secondary infection.
TextSentencer_T242 35233-35406 Sentence denotes Based on these results the rapid weight loss and clinical signs observed upon immunosuppression of HTNV and PUUV infected ferrets was most likely due to secondary infection.
T77184 35407-35574 Sentence denotes Due to the inability to completely manage secondary infection with prophylactic antibiotic treatment, no further immunosuppression studies were carried out in ferrets.
TextSentencer_T243 35407-35574 Sentence denotes Due to the inability to completely manage secondary infection with prophylactic antibiotic treatment, no further immunosuppression studies were carried out in ferrets.
T1124 35575-35709 Sentence denotes To refine the HFRS-causing hantavirus ferret infection model four ferrets were challenged with 94,000 PFU PUUV Beaumont i.m. on Day 0.
TextSentencer_T244 35575-35709 Sentence denotes To refine the HFRS-causing hantavirus ferret infection model four ferrets were challenged with 94,000 PFU PUUV Beaumont i.m. on Day 0.
T70405 35710-35842 Sentence denotes Weight and temperature were recorded daily, while twice weekly blood draws and urine collection was used to monitor kidney function.
TextSentencer_T245 35710-35842 Sentence denotes Weight and temperature were recorded daily, while twice weekly blood draws and urine collection was used to monitor kidney function.
T33501 35843-35975 Sentence denotes As with the pilot experiment, ferrets slowly lost between 7-11% of peak body weight, recapitulating our previous findings (Fig 6A) .
TextSentencer_T246 35843-35975 Sentence denotes As with the pilot experiment, ferrets slowly lost between 7-11% of peak body weight, recapitulating our previous findings (Fig 6A) .
T61773 35976-36025 Sentence denotes No elevated temperatures were observed (Fig 6B) .
TextSentencer_T247 35976-36025 Sentence denotes No elevated temperatures were observed (Fig 6B) .
T4231 36026-36123 Sentence denotes Ferrets developed a robust antibody response beginning on Day 10 post infection (Fig 6C and 6D) .
TextSentencer_T248 36026-36123 Sentence denotes Ferrets developed a robust antibody response beginning on Day 10 post infection (Fig 6C and 6D) .
T13527 36124-36297 Sentence denotes Neutralizing antibodies developed early as Day 14 post infection, and were present in all ferrets by Day 28 post infection, as measured by PsVNA and PRNT ( Fig 6E and 6F) .
TextSentencer_T249 36124-36297 Sentence denotes Neutralizing antibodies developed early as Day 14 post infection, and were present in all ferrets by Day 28 post infection, as measured by PsVNA and PRNT ( Fig 6E and 6F) .
T1519 36298-36370 Sentence denotes Despite the slow weight loss no signs of renal impairment were observed.
TextSentencer_T250 36298-36370 Sentence denotes Despite the slow weight loss no signs of renal impairment were observed.
T35595 36371-36525 Sentence denotes Proteinuria and hematuria are hallmarks of PUUV infection occurring in between 94-100% (proteinuria) and 58-85% (hematuria) of human clinical cases [46] .
TextSentencer_T251 36371-36525 Sentence denotes Proteinuria and hematuria are hallmarks of PUUV infection occurring in between 94-100% (proteinuria) and 58-85% (hematuria) of human clinical cases [46] .
T254 36526-36614 Sentence denotes No prolonged proteinuria or hematuria was observed (Fig 7A and 7B ) in infected ferrets.
TextSentencer_T252 36526-36614 Sentence denotes No prolonged proteinuria or hematuria was observed (Fig 7A and 7B ) in infected ferrets.
T52063 36615-36822 Sentence denotes Similarly, blood urea nitrogen and creatinine levels in the sera, both of which are elevated due to kidney failure in PUUV patients [47] remained unchanged in PUUV infected ferrets (Fig 7C and 7D) [48, 49] .
TextSentencer_T253 36615-36822 Sentence denotes Similarly, blood urea nitrogen and creatinine levels in the sera, both of which are elevated due to kidney failure in PUUV patients [47] remained unchanged in PUUV infected ferrets (Fig 7C and 7D) [48, 49] .
T89955 36823-36959 Sentence denotes No infectious virus or viral genome was detected in the brain, heart, lung, liver, spleen, kidney, intestine, or eye (S11 and S12 Figs).
TextSentencer_T254 36823-36959 Sentence denotes No infectious virus or viral genome was detected in the brain, heart, lung, liver, spleen, kidney, intestine, or eye (S11 and S12 Figs).
T79030 36960-37043 Sentence denotes No changes in other serologic or urologic parameters were noted (S13 and S14 Figs).
TextSentencer_T255 36960-37043 Sentence denotes No changes in other serologic or urologic parameters were noted (S13 and S14 Figs).
T81614 37044-37164 Sentence denotes No gross pathological changes or significant lesions associated with PUUV infection were noted in the ferrets (S15 Fig).
TextSentencer_T256 37044-37164 Sentence denotes No gross pathological changes or significant lesions associated with PUUV infection were noted in the ferrets (S15 Fig).
T55496 37165-37297 Sentence denotes In the lungs, one ferret had mild neutrophilic and histiocytic inflammation centered on the bronchioles and expanded alveolar septa.
TextSentencer_T257 37165-37297 Sentence denotes In the lungs, one ferret had mild neutrophilic and histiocytic inflammation centered on the bronchioles and expanded alveolar septa.
T88233 37298-37434 Sentence denotes Given that the inflammation was centered around bronchioles and not the vasculature, it is unlikely to be in response to PUUV infection.
TextSentencer_T258 37298-37434 Sentence denotes Given that the inflammation was centered around bronchioles and not the vasculature, it is unlikely to be in response to PUUV infection.
T3350 37435-37515 Sentence denotes A number of other common or age-associated lesions were observed in the ferrets.
TextSentencer_T259 37435-37515 Sentence denotes A number of other common or age-associated lesions were observed in the ferrets.
T49160 37516-37730 Sentence denotes Two of four ferrets had proliferative cortical cells in either the adrenal capsule or adrenal cortex that were likely clinically silent as they lack clinical signs consistent with adrenal-associated endocrinopathy.
TextSentencer_T260 37516-37730 Sentence denotes Two of four ferrets had proliferative cortical cells in either the adrenal capsule or adrenal cortex that were likely clinically silent as they lack clinical signs consistent with adrenal-associated endocrinopathy.
T8360 37731-37866 Sentence denotes Additionally, alveolar mineralization was noted in all four ferrets as was eosinophilic and lymphoplasmacytic enteritis, and hepatitis.
TextSentencer_T261 37731-37866 Sentence denotes Additionally, alveolar mineralization was noted in all four ferrets as was eosinophilic and lymphoplasmacytic enteritis, and hepatitis.
T33889 37867-37942 Sentence denotes Two ferrets had fibromyxomatous degeneration of the atrioventricular valve.
TextSentencer_T262 37867-37942 Sentence denotes Two ferrets had fibromyxomatous degeneration of the atrioventricular valve.
T54306 37943-38026 Sentence denotes The spleen, brain, kidney, and pituitary gland were normal in all ferrets examined.
TextSentencer_T263 37943-38026 Sentence denotes The spleen, brain, kidney, and pituitary gland were normal in all ferrets examined.
T42468 38027-38126 Sentence denotes As with ferrets, there is no literature on the susceptibility of marmosets to hantavirus infection.
TextSentencer_T264 38027-38126 Sentence denotes As with ferrets, there is no literature on the susceptibility of marmosets to hantavirus infection.
T56211 38127-38197 Sentence denotes To test this, three male marmosets were exposed to 1,000 PFU HTNV i.m.
TextSentencer_T265 38127-38197 Sentence denotes To test this, three male marmosets were exposed to 1,000 PFU HTNV i.m.
T29011 38198-38322 Sentence denotes Blood was collected weekly to measure seroconversion, serum viremia, as well as serum parameters relating to renal function.
TextSentencer_T266 38198-38322 Sentence denotes Blood was collected weekly to measure seroconversion, serum viremia, as well as serum parameters relating to renal function.
T35269 38323-38445 Sentence denotes All three animals seroconverted by Day 21 post infection (Fig 8A and 8B ) despite displaying no clinical signs of illness.
TextSentencer_T267 38323-38445 Sentence denotes All three animals seroconverted by Day 21 post infection (Fig 8A and 8B ) despite displaying no clinical signs of illness.
T72213 38446-38616 Sentence denotes Neutralizing antibody production began around the same time, and was robust by Day 30 post infection (14, 557 by PsVNA 50 and 10,240-20,480 by PRNT 50 ) (Fig 8C and 8D ).
TextSentencer_T268 38446-38616 Sentence denotes Neutralizing antibody production began around the same time, and was robust by Day 30 post infection (14, 557 by PsVNA 50 and 10,240-20,480 by PRNT 50 ) (Fig 8C and 8D ).
T51233 38617-38828 Sentence denotes Due to low volumes of blood drawn at each time point serum viremia could not be examined for each individual animal, however a pool of sera from all three animals was evaluated at each time point post infection.
TextSentencer_T269 38617-38828 Sentence denotes Due to low volumes of blood drawn at each time point serum viremia could not be examined for each individual animal, however a pool of sera from all three animals was evaluated at each time point post infection.
T71998 38829-38930 Sentence denotes Low levels of serum viremia were detected between days 14 and 28 post infection by RT-PCR ( Fig 8G) .
TextSentencer_T270 38829-38930 Sentence denotes Low levels of serum viremia were detected between days 14 and 28 post infection by RT-PCR ( Fig 8G) .
T83051 38931-39200 Sentence denotes As with the ferret infection model of HFRS-causing hantavirus, no renal injury as measured by changes noted in blood urea nitrogen or serum creatinine were observed over the course of infection, nor were changes in any of the other serum parameters monitored (S16 Fig).
TextSentencer_T271 38931-39200 Sentence denotes As with the ferret infection model of HFRS-causing hantavirus, no renal injury as measured by changes noted in blood urea nitrogen or serum creatinine were observed over the course of infection, nor were changes in any of the other serum parameters monitored (S16 Fig).
T2287 39201-39292 Sentence denotes Animals were euthanized on Day 30 post infection to examine organs for viral dissemination.
TextSentencer_T272 39201-39292 Sentence denotes Animals were euthanized on Day 30 post infection to examine organs for viral dissemination.
T48850 39293-39423 Sentence denotes No infectious virus or viral genome was detected in the heart, lung, liver, spleen, kidney, intestine or brain (S17 and S18 Figs).
TextSentencer_T273 39293-39423 Sentence denotes No infectious virus or viral genome was detected in the heart, lung, liver, spleen, kidney, intestine or brain (S17 and S18 Figs).
T51693 39424-39606 Sentence denotes Lymphoid hyperplasia was noted in all three animals by histology, though the location and intensity varied between the spleen, various lymph nodes and gut associated lymphoid tissue.
TextSentencer_T274 39424-39606 Sentence denotes Lymphoid hyperplasia was noted in all three animals by histology, though the location and intensity varied between the spleen, various lymph nodes and gut associated lymphoid tissue.
T5387 39607-39727 Sentence denotes Such hyperplasia is indicative of a response to antigenic stimulation and was most likely caused by the viral challenge.
TextSentencer_T275 39607-39727 Sentence denotes Such hyperplasia is indicative of a response to antigenic stimulation and was most likely caused by the viral challenge.
T11908 39728-39956 Sentence denotes Mild to moderate congestion Three HFRS-associated hantavirus infection models was also seen in the lungs of each marmoset; however, this was an acute change and was most likely associated with terminal anesthesia and euthanasia.
TextSentencer_T276 39728-39956 Sentence denotes Mild to moderate congestion Three HFRS-associated hantavirus infection models was also seen in the lungs of each marmoset; however, this was an acute change and was most likely associated with terminal anesthesia and euthanasia.
T29200 39957-40048 Sentence denotes No other significant histological lesions were noted in any of the three animals (S19 Fig).
TextSentencer_T277 39957-40048 Sentence denotes No other significant histological lesions were noted in any of the three animals (S19 Fig).
T85418 40049-40206 Sentence denotes Due to the negative virology results and the lack of significant histologic changes, IHC to detect the presence of HTNV antigen in tissues was not performed.
TextSentencer_T278 40049-40206 Sentence denotes Due to the negative virology results and the lack of significant histologic changes, IHC to detect the presence of HTNV antigen in tissues was not performed.
T49275 40207-40325 Sentence denotes To date, the use of adult animal models to evaluate anti-HTNV and anti-PUUV medical counter measures has been limited.
TextSentencer_T279 40207-40325 Sentence denotes To date, the use of adult animal models to evaluate anti-HTNV and anti-PUUV medical counter measures has been limited.
T16458 40326-40455 Sentence denotes Recombinant protein, vaccinia virus-vectored, and DNA vaccines have been tested in the high dose HTNV hamster model [9, 37, 50] .
TextSentencer_T280 40326-40455 Sentence denotes Recombinant protein, vaccinia virus-vectored, and DNA vaccines have been tested in the high dose HTNV hamster model [9, 37, 50] .
T60636 40456-40657 Sentence denotes Additionally, the ability of passively administered neutralizing antibodies has been evaluated in the high-dose hamster model of HTNV and PUUV and in PUUV challenged cynomolgus macaques PUUV [50, 51] .
TextSentencer_T281 40456-40657 Sentence denotes Additionally, the ability of passively administered neutralizing antibodies has been evaluated in the high-dose hamster model of HTNV and PUUV and in PUUV challenged cynomolgus macaques PUUV [50, 51] .
T9153 40658-40947 Sentence denotes Both of these models have limitations; the size of the macaque requires large quantities of passive transfer material, and the high dose of the hamster model, with challenge doses of~650 ID 99 , could require prohibitively large volumes of test article to neutralize the high initial dose.
TextSentencer_T282 40658-40947 Sentence denotes Both of these models have limitations; the size of the macaque requires large quantities of passive transfer material, and the high dose of the hamster model, with challenge doses of~650 ID 99 , could require prohibitively large volumes of test article to neutralize the high initial dose.
T33261 40948-41104 Sentence denotes Suckling mice, which present with a disseminated disease not reminiscent of HFRS, have been used to evaluate HTNV therapeutics as well [52] [53] [54] [55] .
TextSentencer_T283 40948-41104 Sentence denotes Suckling mice, which present with a disseminated disease not reminiscent of HFRS, have been used to evaluate HTNV therapeutics as well [52] [53] [54] [55] .
T92635 41105-41272 Sentence denotes In this paper we present three adult animal models of HFRS-causing hantavirus infection than can be used for future evaluation of therapeutics, biologics and vaccines.
TextSentencer_T284 41105-41272 Sentence denotes In this paper we present three adult animal models of HFRS-causing hantavirus infection than can be used for future evaluation of therapeutics, biologics and vaccines.
T74740 41273-41441 Sentence denotes The ID 50 's for HTNV and PUUV determined in this report are similar to the lethal dose 50% (LD 50 ) calculated for SNV and ANDV, <3 PFU via the i.m. route [6, 7, 41] .
TextSentencer_T285 41273-41441 Sentence denotes The ID 50 's for HTNV and PUUV determined in this report are similar to the lethal dose 50% (LD 50 ) calculated for SNV and ANDV, <3 PFU via the i.m. route [6, 7, 41] .
T18274 41442-41591 Sentence denotes Also similar is that the challenge dose of ANDV required to infect/kill 50% of hamsters by the i.n. or intragastric route is~10-30 fold higher [56] .
TextSentencer_T286 41442-41591 Sentence denotes Also similar is that the challenge dose of ANDV required to infect/kill 50% of hamsters by the i.n. or intragastric route is~10-30 fold higher [56] .
T80950 41592-41779 Sentence denotes Previous reports also demonstrate that PUUV is capable of infecting hamsters by the intragastric route, with an ID 50 of >10,000, making it a much less effective route of infection [57] .
TextSentencer_T287 41592-41779 Sentence denotes Previous reports also demonstrate that PUUV is capable of infecting hamsters by the intragastric route, with an ID 50 of >10,000, making it a much less effective route of infection [57] .
T20739 41780-42006 Sentence denotes Despite similarities in their ID 50 's, the ID 99 's of HTNV and PUUV greatly diverge, with~200 times less HTNV required to infect hamsters via the i.m. route, and~2 fold less required to infect via the i.n. route ( Table 1 ).
TextSentencer_T288 41780-42006 Sentence denotes Despite similarities in their ID 50 's, the ID 99 's of HTNV and PUUV greatly diverge, with~200 times less HTNV required to infect hamsters via the i.m. route, and~2 fold less required to infect via the i.n. route ( Table 1 ).
T98439 42007-42188 Sentence denotes The lower ID 99 doses, coupled with viral persistence in HTNV infected animals as opposed to viral clearance (Fig 3) , suggest that HTNV is more infectious than PUUV in the hamster.
TextSentencer_T289 42007-42188 Sentence denotes The lower ID 99 doses, coupled with viral persistence in HTNV infected animals as opposed to viral clearance (Fig 3) , suggest that HTNV is more infectious than PUUV in the hamster.
T61594 42189-42282 Sentence denotes The mechanism for this difference between these closely related hantaviruses remains unknown.
TextSentencer_T290 42189-42282 Sentence denotes The mechanism for this difference between these closely related hantaviruses remains unknown.
T86160 42283-42444 Sentence denotes Lethal infection of hamsters with ANDV leads to extensive organ dissemination, with infectious virus recovered in the lung, liver, kidney, spleen and heart [6] .
TextSentencer_T291 42283-42444 Sentence denotes Lethal infection of hamsters with ANDV leads to extensive organ dissemination, with infectious virus recovered in the lung, liver, kidney, spleen and heart [6] .
T2223 42445-42565 Sentence denotes Asymptomatic infection of hamsters with SNV repeatedly passaged through hamsters has a similar organ distribution [58] .
TextSentencer_T292 42445-42565 Sentence denotes Asymptomatic infection of hamsters with SNV repeatedly passaged through hamsters has a similar organ distribution [58] .
T76385 42566-42686 Sentence denotes The organ distribution of both those viruses is similar to the low dose HTNV hamster model, with two notable exceptions.
TextSentencer_T293 42566-42686 Sentence denotes The organ distribution of both those viruses is similar to the low dose HTNV hamster model, with two notable exceptions.
T66722 42687-42808 Sentence denotes First, the HTNV model has low, transient levels of virus in the liver and hardly any virus in the spleen (Figs 3 and 4) .
TextSentencer_T294 42687-42808 Sentence denotes First, the HTNV model has low, transient levels of virus in the liver and hardly any virus in the spleen (Figs 3 and 4) .
T95750 42809-43029 Sentence denotes This dissimilarity between the models led us to confirm the lack of virus in the spleen was not due to the presence of inhibitors by spiking either infectious virus or viral RNA into samples prior to evaluation (S2 Fig).
TextSentencer_T295 42809-43029 Sentence denotes This dissimilarity between the models led us to confirm the lack of virus in the spleen was not due to the presence of inhibitors by spiking either infectious virus or viral RNA into samples prior to evaluation (S2 Fig).
T64214 43030-43173 Sentence denotes Second, in the ANDV model, the presence of virus was determined by plaque assay, indicating the virus was infectious and replication competent.
TextSentencer_T296 43030-43173 Sentence denotes Second, in the ANDV model, the presence of virus was determined by plaque assay, indicating the virus was infectious and replication competent.
T15417 43174-43473 Sentence denotes In the HTNV low dose hamster model, while there is detection of high levels of viral genome (and in the case of the HTNV i.m. model, by pathology) by RT-PCR, recovery of infectious virus is sporadic, typically occurring at low levels, in only a few hamsters per time point (Figs 3 and 4 , Table 1 ).
TextSentencer_T297 43174-43473 Sentence denotes In the HTNV low dose hamster model, while there is detection of high levels of viral genome (and in the case of the HTNV i.m. model, by pathology) by RT-PCR, recovery of infectious virus is sporadic, typically occurring at low levels, in only a few hamsters per time point (Figs 3 and 4 , Table 1 ).
T7593 43474-43543 Sentence denotes The discrepancy between RT-PCR/pathology and plaque assay is notable.
TextSentencer_T298 43474-43543 Sentence denotes The discrepancy between RT-PCR/pathology and plaque assay is notable.
T52989 43544-43784 Sentence denotes The hamsters in this study were not perfused, and given the appearance of neutralizing antibodies as early as day XX post infection, the presence of these antibodies could be impairing out ability to recover live virus via the plaque assay.
TextSentencer_T299 43544-43784 Sentence denotes The hamsters in this study were not perfused, and given the appearance of neutralizing antibodies as early as day XX post infection, the presence of these antibodies could be impairing out ability to recover live virus via the plaque assay.
T75206 43785-43947 Sentence denotes It is also possible that viral packaging is somehow impaired in the hamster, leading to a larger amounts of nucleocapsid protein and viral genome than live virus.
TextSentencer_T300 43785-43947 Sentence denotes It is also possible that viral packaging is somehow impaired in the hamster, leading to a larger amounts of nucleocapsid protein and viral genome than live virus.
T45951 43948-43999 Sentence denotes Further studies need to be undertaken to elucidate.
TextSentencer_T301 43948-43999 Sentence denotes Further studies need to be undertaken to elucidate.
T98288 44000-44288 Sentence denotes The low dose HTNV hamster model also mimics the infection pattern of the virus in its host species, the striped field mouse (Apodemus agrarius), with viral genome being detected in the lung, liver and kidney but not the spleen (the heart and brain were not examined) [32, [59] [60] [61] .
TextSentencer_T302 44000-44288 Sentence denotes The low dose HTNV hamster model also mimics the infection pattern of the virus in its host species, the striped field mouse (Apodemus agrarius), with viral genome being detected in the lung, liver and kidney but not the spleen (the heart and brain were not examined) [32, [59] [60] [61] .
T26933 44289-44401 Sentence denotes In contrast to the HTNV low dose model, the organ distribution of virus in the PUUV low dose model is transient.
TextSentencer_T303 44289-44401 Sentence denotes In contrast to the HTNV low dose model, the organ distribution of virus in the PUUV low dose model is transient.
T88863 44402-44564 Sentence denotes In PUUV i.m. infected hamsters virus is detectable by RT-PCR around Day 11 post infection, with the virus being cleared from all organs except the lung by Day 24.
TextSentencer_T304 44402-44564 Sentence denotes In PUUV i.m. infected hamsters virus is detectable by RT-PCR around Day 11 post infection, with the virus being cleared from all organs except the lung by Day 24.
T40261 44565-44626 Sentence denotes No infectious virus was recovered at any time point examined.
TextSentencer_T305 44565-44626 Sentence denotes No infectious virus was recovered at any time point examined.
T1569 44627-44753 Sentence denotes Even less virus was detected in the PUUV i.n. model; only a small amount in the brain of one hamster on Day 28 post infection.
TextSentencer_T306 44627-44753 Sentence denotes Even less virus was detected in the PUUV i.n. model; only a small amount in the brain of one hamster on Day 28 post infection.
T43972 44754-44813 Sentence denotes In neither case was serum viremia observed (Figs 3 and 4) .
TextSentencer_T307 44754-44813 Sentence denotes In neither case was serum viremia observed (Figs 3 and 4) .
T51541 44814-45068 Sentence denotes This is most similar to the SNV models involving low passage virus in immunocompetent hamsters: the virus is transiently detected in the lung by PCR, and then sporadically found in organs 12 to 14 days post infection using immunohistochemistry [41, 58] .
TextSentencer_T308 44814-45068 Sentence denotes This is most similar to the SNV models involving low passage virus in immunocompetent hamsters: the virus is transiently detected in the lung by PCR, and then sporadically found in organs 12 to 14 days post infection using immunohistochemistry [41, 58] .
T27672 45069-45277 Sentence denotes The distribution of PUUV in the hamster differs somewhat from its host species the bank vole, where it is found to persist in the lung, spleen and kidney, and was not detected in the heart or the brain [62] .
TextSentencer_T309 45069-45277 Sentence denotes The distribution of PUUV in the hamster differs somewhat from its host species the bank vole, where it is found to persist in the lung, spleen and kidney, and was not detected in the heart or the brain [62] .
T60267 45278-45437 Sentence denotes Seroconversion of hamsters post viral exposure remains the best way to measure infection, and should be a considered the primary endpoint for efficacy studies.
TextSentencer_T310 45278-45437 Sentence denotes Seroconversion of hamsters post viral exposure remains the best way to measure infection, and should be a considered the primary endpoint for efficacy studies.
T20781 45438-45772 Sentence denotes Though the PRNT assay was slightly more sensitive than the N-ELISA assay, detecting neutralizing antibodies in all animals with N-ELISA titers, and in two PUUV animals that did not have N-ELISA titers, the increased time, sample, and biosafety requirements necessary for a PRNT assay make the N-ELISA a better choice (Fig 2, S1 Fig) .
TextSentencer_T311 45438-45772 Sentence denotes Though the PRNT assay was slightly more sensitive than the N-ELISA assay, detecting neutralizing antibodies in all animals with N-ELISA titers, and in two PUUV animals that did not have N-ELISA titers, the increased time, sample, and biosafety requirements necessary for a PRNT assay make the N-ELISA a better choice (Fig 2, S1 Fig) .
T24716 45773-46156 Sentence denotes For a 10 PFU HTNV i.m. challenge, given lower titer and specific OD sum values as compared with higher challenge doses, and the fact that one hamster with significant viral genome in its organs at Day 28 post infection (7.1 log 10 in the brain, and 6.8 log 10 in the kidney) did not seroconvert, waiting until Day 35 post infection to monitor seroconversion is advisable (Figs 1-3 ).
TextSentencer_T312 45773-46156 Sentence denotes For a 10 PFU HTNV i.m. challenge, given lower titer and specific OD sum values as compared with higher challenge doses, and the fact that one hamster with significant viral genome in its organs at Day 28 post infection (7.1 log 10 in the brain, and 6.8 log 10 in the kidney) did not seroconvert, waiting until Day 35 post infection to monitor seroconversion is advisable (Figs 1-3 ).
T25338 46157-46330 Sentence denotes Viral load in the brain, kidney, and lungs as measured by RT-PCR need to be evaluated at Day 35 post low-dose challenge to determine their usefulness as secondary endpoints.
TextSentencer_T313 46157-46330 Sentence denotes Viral load in the brain, kidney, and lungs as measured by RT-PCR need to be evaluated at Day 35 post low-dose challenge to determine their usefulness as secondary endpoints.
T67998 46331-46443 Sentence denotes Recovery of infectious virus in any organ, and viremia are too sporadic to serve as proxy markers for infection.
TextSentencer_T314 46331-46443 Sentence denotes Recovery of infectious virus in any organ, and viremia are too sporadic to serve as proxy markers for infection.
T1688 46444-46677 Sentence denotes The ferret has been used as an experimental model for numerous hemorrhagic fever viruses, and respiratory viruses [12] [13] [14] [15] [16] [17] , though no published reports exist examining its susceptibility to hantavirus infection.
TextSentencer_T315 46444-46677 Sentence denotes The ferret has been used as an experimental model for numerous hemorrhagic fever viruses, and respiratory viruses [12] [13] [14] [15] [16] [17] , though no published reports exist examining its susceptibility to hantavirus infection.
T64722 46678-46768 Sentence denotes In comparison to the hamster, the ferret is far more resistant to HTNV and PUUV infection.
TextSentencer_T316 46678-46768 Sentence denotes In comparison to the hamster, the ferret is far more resistant to HTNV and PUUV infection.
T87761 46769-46924 Sentence denotes Exposure of ferrets to 2,000 PFU i.n. (greater than the ID 99 for both viruses in hamsters), failed to result in a productive infection and seroconversion.
TextSentencer_T317 46769-46924 Sentence denotes Exposure of ferrets to 2,000 PFU i.n. (greater than the ID 99 for both viruses in hamsters), failed to result in a productive infection and seroconversion.
T60229 46925-46998 Sentence denotes Instead i.m. challenge doses of~100,000-200,000 PFU were needed (Fig 5) .
TextSentencer_T318 46925-46998 Sentence denotes Instead i.m. challenge doses of~100,000-200,000 PFU were needed (Fig 5) .
T19515 46999-47126 Sentence denotes Initially ferrets were exposed to PUUV K27, a commonly used laboratory isolate that has been in cell culture for over 15 years.
TextSentencer_T319 46999-47126 Sentence denotes Initially ferrets were exposed to PUUV K27, a commonly used laboratory isolate that has been in cell culture for over 15 years.
T84200 47127-47204 Sentence denotes Repeated passaging of hantavirus is known to cause mutations [63] [64] [65] .
TextSentencer_T320 47127-47204 Sentence denotes Repeated passaging of hantavirus is known to cause mutations [63] [64] [65] .
T79800 47205-47337 Sentence denotes In contrast PUUV Beaumont and Seloignes are relatively recent isolates, with no more than 3 passages in cell culture post isolation.
TextSentencer_T321 47205-47337 Sentence denotes In contrast PUUV Beaumont and Seloignes are relatively recent isolates, with no more than 3 passages in cell culture post isolation.
T18347 47338-47519 Sentence denotes These strains were used for all subsequent experiments to maximize the likelihood of PUUV to cause disease by eliminating possible attenuation of the laboratory strain of the virus.
TextSentencer_T322 47338-47519 Sentence denotes These strains were used for all subsequent experiments to maximize the likelihood of PUUV to cause disease by eliminating possible attenuation of the laboratory strain of the virus.
T89077 47520-47844 Sentence denotes Despite the high challenge dose and use of recent isolates, no elevation in white blood cells was observed over the course of the experiment, no pathology or organ burden was detected at the conclusion of the experiment, and the N-ELISA specific OD sum, PRNT 50 , and PsVNA 50 titers remained low (Figs 6 and 8 and S9 Fig) .
TextSentencer_T323 47520-47844 Sentence denotes Despite the high challenge dose and use of recent isolates, no elevation in white blood cells was observed over the course of the experiment, no pathology or organ burden was detected at the conclusion of the experiment, and the N-ELISA specific OD sum, PRNT 50 , and PsVNA 50 titers remained low (Figs 6 and 8 and S9 Fig) .
T91537 47845-48047 Sentence denotes This outcome is almost identical to that of Marburg and Ravn virus infection in ferrets, where the development of neutralizing antibody titers was the only sign that productive infection occurred [66] .
TextSentencer_T324 47845-48047 Sentence denotes This outcome is almost identical to that of Marburg and Ravn virus infection in ferrets, where the development of neutralizing antibody titers was the only sign that productive infection occurred [66] .
T76373 48048-48250 Sentence denotes Previous experiments in hamsters, have demonstrated that 2x10 5 PFU of gamma-irradiated ANDV and SNV are not sufficient to cause seroconversion, and neither is 1x10 4 gamma-irradiated PFU PUUV [6, 57] .
TextSentencer_T325 48048-48250 Sentence denotes Previous experiments in hamsters, have demonstrated that 2x10 5 PFU of gamma-irradiated ANDV and SNV are not sufficient to cause seroconversion, and neither is 1x10 4 gamma-irradiated PFU PUUV [6, 57] .
T14226 48251-48423 Sentence denotes Thus the seroconversion observed in ferrets, though low, is not likely to be due to a reaction to the large quantity of antigen administered, but to a productive infection.
TextSentencer_T326 48251-48423 Sentence denotes Thus the seroconversion observed in ferrets, though low, is not likely to be due to a reaction to the large quantity of antigen administered, but to a productive infection.
T51536 48424-48740 Sentence denotes PUUV antigen, viral genome, or infectious virus has been found in the brain, pituitary gland, lung, heart, liver, kidney, spleen, cerebrospinal fluid, and gastrointestinal tract of human patients with clinical symptoms of NE, though the pattern of viral dissemination varies between individuals [67] [68] [69] [70] .
TextSentencer_T327 48424-48740 Sentence denotes PUUV antigen, viral genome, or infectious virus has been found in the brain, pituitary gland, lung, heart, liver, kidney, spleen, cerebrospinal fluid, and gastrointestinal tract of human patients with clinical symptoms of NE, though the pattern of viral dissemination varies between individuals [67] [68] [69] [70] .
T24631 48741-48995 Sentence denotes Acute kidney injury and vision disturbances including blurred vision, myopic shift, and lens thickening, while pulmonary involvement including pleural effusion and vascular congestion, and renal failure occurred less frequently [47, [71] [72] [73] [74] .
TextSentencer_T328 48741-48995 Sentence denotes Acute kidney injury and vision disturbances including blurred vision, myopic shift, and lens thickening, while pulmonary involvement including pleural effusion and vascular congestion, and renal failure occurred less frequently [47, [71] [72] [73] [74] .
T86683 48996-49202 Sentence denotes Given the lack of high neutralizing antibody titers, which could have aided in viral clearance, the lack of viral genome in any of the ferret organs examined is rather surprising (S6, S7, S11 and S12 Figs).
TextSentencer_T329 48996-49202 Sentence denotes Given the lack of high neutralizing antibody titers, which could have aided in viral clearance, the lack of viral genome in any of the ferret organs examined is rather surprising (S6, S7, S11 and S12 Figs).
T17039 49203-49468 Sentence denotes Furthermore, the lack of viral antigen and pathology in the organs tested suggest either a transient infection cleared prior to Day 35 post infection, levels of virus so low as to be undetectable by the tests used, or a viral reservoir outside of the organs tested.
TextSentencer_T330 49203-49468 Sentence denotes Furthermore, the lack of viral antigen and pathology in the organs tested suggest either a transient infection cleared prior to Day 35 post infection, levels of virus so low as to be undetectable by the tests used, or a viral reservoir outside of the organs tested.
T55699 49469-49588 Sentence denotes The lack of detectable virus is most surprising given the gradual weight loss infected animals exhibit (Figs 5 and 6 ).
TextSentencer_T331 49469-49588 Sentence denotes The lack of detectable virus is most surprising given the gradual weight loss infected animals exhibit (Figs 5 and 6 ).
T25630 49589-49743 Sentence denotes The animals gained weight until~3 days post challenge, at which point a gradual weight loss occurs, regardless of if HTNV or PUUV was the challenge virus.
TextSentencer_T332 49589-49743 Sentence denotes The animals gained weight until~3 days post challenge, at which point a gradual weight loss occurs, regardless of if HTNV or PUUV was the challenge virus.
T35343 49744-50122 Sentence denotes While weight loss is a feature of other ferret models of infectious diseases, the pattern we observed was unique: ferrets infected with morbillivirus, avian influenza and filoviruses rapidly lose weight during the first week to two weeks post infection, while infection with severe acute respiratory syndrome virus results in no significant weight loss [16, 17, [75] [76] [77] .
TextSentencer_T333 49744-50122 Sentence denotes While weight loss is a feature of other ferret models of infectious diseases, the pattern we observed was unique: ferrets infected with morbillivirus, avian influenza and filoviruses rapidly lose weight during the first week to two weeks post infection, while infection with severe acute respiratory syndrome virus results in no significant weight loss [16, 17, [75] [76] [77] .
T92866 50123-50213 Sentence denotes In the hamster, infection with SNV is asymptomatic unless the hamster is immunosuppressed.
TextSentencer_T334 50123-50213 Sentence denotes In the hamster, infection with SNV is asymptomatic unless the hamster is immunosuppressed.
T87327 50214-50323 Sentence denotes When ferrets were immunosuppressed on Day 42 post infection, rapid weight loss and lethargy ensured (Fig 5) .
TextSentencer_T335 50214-50323 Sentence denotes When ferrets were immunosuppressed on Day 42 post infection, rapid weight loss and lethargy ensured (Fig 5) .
T31594 50324-50493 Sentence denotes Given that these clinical signs were also observed in unchallenged control animals (S10 Fig) , this could likely be the result of a secondary infection or drug toxicity.
TextSentencer_T336 50324-50493 Sentence denotes Given that these clinical signs were also observed in unchallenged control animals (S10 Fig) , this could likely be the result of a secondary infection or drug toxicity.
T57378 50494-50647 Sentence denotes The use of Cyp is well documented in ferrets, primarily given at a high dose as an emetic, and no dosage for long term immunosuppression was found [78] .
TextSentencer_T337 50494-50647 Sentence denotes The use of Cyp is well documented in ferrets, primarily given at a high dose as an emetic, and no dosage for long term immunosuppression was found [78] .
T30454 50648-50904 Sentence denotes The dosages used in this study (between 10-30 mg/kg) successfully reduced white blood cell levels, in ferrets and demonstrate that Cyp can be used to induce long-term immunosuppression, if antibiotics are given to control for secondary infection (S8 Fig) .
TextSentencer_T338 50648-50904 Sentence denotes The dosages used in this study (between 10-30 mg/kg) successfully reduced white blood cell levels, in ferrets and demonstrate that Cyp can be used to induce long-term immunosuppression, if antibiotics are given to control for secondary infection (S8 Fig) .
T45829 50905-51066 Sentence denotes Despite not being able to detect infectious virus or viral genome in the kidney, we hypothesized that the weight loss we observed could be due to kidney failure.
TextSentencer_T339 50905-51066 Sentence denotes Despite not being able to detect infectious virus or viral genome in the kidney, we hypothesized that the weight loss we observed could be due to kidney failure.
T23016 51067-51175 Sentence denotes Individuals with HFRS exhibit proteinuria and hematuria, both of which can indicate kidney damage [46, 47] .
TextSentencer_T340 51067-51175 Sentence denotes Individuals with HFRS exhibit proteinuria and hematuria, both of which can indicate kidney damage [46, 47] .
T31225 51176-51339 Sentence denotes Additionally, serum blood urea nitrogen and creatinine levels are both elevated in HFRS patients and provide a second way to measure kidney function [46, 47, 73] .
TextSentencer_T341 51176-51339 Sentence denotes Additionally, serum blood urea nitrogen and creatinine levels are both elevated in HFRS patients and provide a second way to measure kidney function [46, 47, 73] .
T69094 51340-51445 Sentence denotes Decreased platelet levels also characterize clinical HFRS in humans, impairing coagulation [46, 47, 73] .
TextSentencer_T342 51340-51445 Sentence denotes Decreased platelet levels also characterize clinical HFRS in humans, impairing coagulation [46, 47, 73] .
T2433 51446-51609 Sentence denotes In a second experiment designed to monitor kidney parameters, PUUV infected ferrets exhibited the same gradual weight loss that characterized the first experiment.
TextSentencer_T343 51446-51609 Sentence denotes In a second experiment designed to monitor kidney parameters, PUUV infected ferrets exhibited the same gradual weight loss that characterized the first experiment.
T45910 51610-51784 Sentence denotes However, no prolonged signs of clinical kidney failure were observed: blood urea nitrogen and creatinine levels did not dramatically increase over the five week study period.
TextSentencer_T344 51610-51784 Sentence denotes However, no prolonged signs of clinical kidney failure were observed: blood urea nitrogen and creatinine levels did not dramatically increase over the five week study period.
T95500 51785-51904 Sentence denotes Only one animal exhibited proteinuria (day 35), and two exhibited hematuria (one on Day 4, and one on Day 21) (Fig 7) .
TextSentencer_T345 51785-51904 Sentence denotes Only one animal exhibited proteinuria (day 35), and two exhibited hematuria (one on Day 4, and one on Day 21) (Fig 7) .
T99155 51905-52027 Sentence denotes Similarly to parameters monitoring renal failure, no thrombocytopenia occurred in PUUV infected ferrets (S9 and S13 Figs).
TextSentencer_T346 51905-52027 Sentence denotes Similarly to parameters monitoring renal failure, no thrombocytopenia occurred in PUUV infected ferrets (S9 and S13 Figs).
T98799 52028-52078 Sentence denotes The cause of the weight loss remains undetermined.
TextSentencer_T347 52028-52078 Sentence denotes The cause of the weight loss remains undetermined.
T24881 52079-52217 Sentence denotes Though susceptible to both HTNV and PUUV, the ferret has limited usefulness for studies involving medical countermeasure efficacy testing.
TextSentencer_T348 52079-52217 Sentence denotes Though susceptible to both HTNV and PUUV, the ferret has limited usefulness for studies involving medical countermeasure efficacy testing.
T10036 52218-52331 Sentence denotes The ferret's large mass, even as an adolescent, makes the amount of test article needed also prohibitively large.
TextSentencer_T349 52218-52331 Sentence denotes The ferret's large mass, even as an adolescent, makes the amount of test article needed also prohibitively large.
T15910 52332-52503 Sentence denotes The large challenge dose required for infection could potentially obscure the protective effect of drugs of vaccines, due to the overwhelming amount of virus administered.
TextSentencer_T350 52332-52503 Sentence denotes The large challenge dose required for infection could potentially obscure the protective effect of drugs of vaccines, due to the overwhelming amount of virus administered.
T69068 52504-52659 Sentence denotes Moreover, although the animals are infected the resultant neutralizing antibody titers are small, resulting in potential sensitivity issues with the model.
TextSentencer_T351 52504-52659 Sentence denotes Moreover, although the animals are infected the resultant neutralizing antibody titers are small, resulting in potential sensitivity issues with the model.
T34477 52660-52844 Sentence denotes Husbandry and handling of the animals under ABSL-3 procedures is also substantially more difficult than hamsters, and they lack the genetic similarity to humans that marmosets possess.
TextSentencer_T352 52660-52844 Sentence denotes Husbandry and handling of the animals under ABSL-3 procedures is also substantially more difficult than hamsters, and they lack the genetic similarity to humans that marmosets possess.
T90514 52845-52930 Sentence denotes In this study we have demonstrated the susceptibility of marmosets to HTNV infection.
TextSentencer_T353 52845-52930 Sentence denotes In this study we have demonstrated the susceptibility of marmosets to HTNV infection.
T51388 52931-53096 Sentence denotes Marmosets represent an attractive model for testing vaccines and therapeutics against HFRS-causing hantaviruses due to genetic similarities to humans and small size.
TextSentencer_T354 52931-53096 Sentence denotes Marmosets represent an attractive model for testing vaccines and therapeutics against HFRS-causing hantaviruses due to genetic similarities to humans and small size.
T47217 53097-53311 Sentence denotes Also, the model has a simple read-out of infection, i.e. robust antibody production as measured by N-ELISA and PsVNA, making the determination of protection by vaccine or passive transfer material, straightforward.
TextSentencer_T355 53097-53311 Sentence denotes Also, the model has a simple read-out of infection, i.e. robust antibody production as measured by N-ELISA and PsVNA, making the determination of protection by vaccine or passive transfer material, straightforward.
T47743 53312-53527 Sentence denotes Further optimization of the model, namely to determine the ID 99 , could prove important as a 1,000 PFU challenge dose could be excessively high and prohibit therapeutic effects of candidate medical countermeasures.
TextSentencer_T356 53312-53527 Sentence denotes Further optimization of the model, namely to determine the ID 99 , could prove important as a 1,000 PFU challenge dose could be excessively high and prohibit therapeutic effects of candidate medical countermeasures.
T31298 53528-53676 Sentence denotes Overall the marmoset model is more similar to the ferret HFRS-causing hantavirus infection model than the hamster, though there are key differences.
TextSentencer_T357 53528-53676 Sentence denotes Overall the marmoset model is more similar to the ferret HFRS-causing hantavirus infection model than the hamster, though there are key differences.
T2728 53677-53811 Sentence denotes Like the ferret, no significant pathological abnormalities were noted, and no signs of renal failure were observed (S16 and S19 Figs).
TextSentencer_T358 53677-53811 Sentence denotes Like the ferret, no significant pathological abnormalities were noted, and no signs of renal failure were observed (S16 and S19 Figs).
T71518 53812-53931 Sentence denotes Serum chemistry values do not differ from the normal range with the exception of albumin, total bilirubin, and amylase.
TextSentencer_T359 53812-53931 Sentence denotes Serum chemistry values do not differ from the normal range with the exception of albumin, total bilirubin, and amylase.
T58209 53932-54091 Sentence denotes While these values fell outside the normal range, they did not change over the course of infection indicating the problem may lie in the reference values used.
TextSentencer_T360 53932-54091 Sentence denotes While these values fell outside the normal range, they did not change over the course of infection indicating the problem may lie in the reference values used.
T75070 54092-54288 Sentence denotes The Piccolo general chemistry panel used to evaluate the parameters is optimized for human testing, and therefore may be less than optimal for evaluating the marmoset, especially those parameters.
TextSentencer_T361 54092-54288 Sentence denotes The Piccolo general chemistry panel used to evaluate the parameters is optimized for human testing, and therefore may be less than optimal for evaluating the marmoset, especially those parameters.
T73168 54289-54403 Sentence denotes Additionally, no infectious virus or viral genome was recovered from any organ at Day 30 post infection [79, 80] .
TextSentencer_T362 54289-54403 Sentence denotes Additionally, no infectious virus or viral genome was recovered from any organ at Day 30 post infection [79, 80] .
T31173 54404-54529 Sentence denotes This is not surprising, given the high levels of neutralizing antibodies present as early as 21 days post infection (Fig 8) .
TextSentencer_T363 54404-54529 Sentence denotes This is not surprising, given the high levels of neutralizing antibodies present as early as 21 days post infection (Fig 8) .
T38808 54530-54771 Sentence denotes Unlike the ferret, however, marmosets develop exceptionally high neutralizing antibody titers (10,240-20,480 by PRNT 50 and 14,866-221,557 by PsVNA 50 ), and display low-level serum viremia between two and four weeks post infection (Fig 8) .
TextSentencer_T364 54530-54771 Sentence denotes Unlike the ferret, however, marmosets develop exceptionally high neutralizing antibody titers (10,240-20,480 by PRNT 50 and 14,866-221,557 by PsVNA 50 ), and display low-level serum viremia between two and four weeks post infection (Fig 8) .
T52627 54772-55007 Sentence denotes The serum viremia is significantly lower than in hamsters infected with HTNV, where some animals displayed RT-PCR titers of >7log 10 , and in hamsters infected with ANDV, where infectious virus titers prior to death are > 6log 10 [41].
TextSentencer_T365 54772-55007 Sentence denotes The serum viremia is significantly lower than in hamsters infected with HTNV, where some animals displayed RT-PCR titers of >7log 10 , and in hamsters infected with ANDV, where infectious virus titers prior to death are > 6log 10 [41].
T92173 55008-55220 Sentence denotes Despite not exhibiting clinical signs of disease, the model's robust antibody response (as measured by PRNT, PsVNA and N-ELISA) make it a useful tool for evaluating vaccines and pre-or post-exposure therapeutics.
TextSentencer_T366 55008-55220 Sentence denotes Despite not exhibiting clinical signs of disease, the model's robust antibody response (as measured by PRNT, PsVNA and N-ELISA) make it a useful tool for evaluating vaccines and pre-or post-exposure therapeutics.
T77378 55221-55402 Sentence denotes This paper has explored the use of three laboratory animal species as possible infection and disease models for HFRS-causing hantaviruses: the hamster, the ferret, and the marmoset.
TextSentencer_T367 55221-55402 Sentence denotes This paper has explored the use of three laboratory animal species as possible infection and disease models for HFRS-causing hantaviruses: the hamster, the ferret, and the marmoset.
T38458 55403-55566 Sentence denotes These models, especially the hamster model and marmoset model, will be useful for evaluating medical countermeasures with the potential to induce sterile immunity.
TextSentencer_T368 55403-55566 Sentence denotes These models, especially the hamster model and marmoset model, will be useful for evaluating medical countermeasures with the potential to induce sterile immunity.
T34074 55567-55911 Sentence denotes The marmosets should be particularly useful for the evaluation of passively transferred protective human antibodies because of the relative genetic similarities between species in the Order Primates, and the small size of marmosets, allowing testing with smaller volumes of material than would be required for larger species such as macaques. .
TextSentencer_T369 55567-55911 Sentence denotes The marmosets should be particularly useful for the evaluation of passively transferred protective human antibodies because of the relative genetic similarities between species in the Order Primates, and the small size of marmosets, allowing testing with smaller volumes of material than would be required for larger species such as macaques. .
T33629 55912-56046 Sentence denotes Heart, lung, liver, spleen, kidney, and intestine were collected and assayed by plaque assay for the presence of infectious virus (A).
TextSentencer_T370 55912-56046 Sentence denotes Heart, lung, liver, spleen, kidney, and intestine were collected and assayed by plaque assay for the presence of infectious virus (A).
T64262 56047-56208 Sentence denotes To confirm lack of virus recovered was not due to inhibitors, virus was spiked into serial dilutions of organ homogenate to confirm no inhibitor was present (B).
TextSentencer_T371 56047-56208 Sentence denotes To confirm lack of virus recovered was not due to inhibitors, virus was spiked into serial dilutions of organ homogenate to confirm no inhibitor was present (B).
T58211 56209-56310 Sentence denotes For a standard plaque assay the limit of detection, 1.7 log 10 , is depicted as a dashed line in (A).
TextSentencer_T372 56209-56310 Sentence denotes For a standard plaque assay the limit of detection, 1.7 log 10 , is depicted as a dashed line in (A).
T88417 56311-56538 Sentence denotes In (B) the dashed line is amount of HTNV plaques obtained when spiked into media rather than organ homogenate. (TIF) S10 Fig. Immunosuppression of uninfected ferrets leads to rapid weight loss and secondary bacterial infection.
TextSentencer_T373 56311-56538 Sentence denotes In (B) the dashed line is amount of HTNV plaques obtained when spiked into media rather than organ homogenate. (TIF) S10 Fig. Immunosuppression of uninfected ferrets leads to rapid weight loss and secondary bacterial infection.
T92961 56539-56655 Sentence denotes Uninfected ferrets were administered 10mg/kg Cyp, and the antibiotic enrofloxicin, according to the schedule in (A).
TextSentencer_T374 56539-56655 Sentence denotes Uninfected ferrets were administered 10mg/kg Cyp, and the antibiotic enrofloxicin, according to the schedule in (A).
T90344 56656-56881 Sentence denotes Weight (B) and temperature (C) are shown. b.i.d indicates antibody was administered twice daily, and q.d indicates antibiotic was administered daily. (TIF) S11 Fig. PUUV infected ferrets had no infectious virus in the organs.
TextSentencer_T375 56656-56881 Sentence denotes Weight (B) and temperature (C) are shown. b.i.d indicates antibody was administered twice daily, and q.d indicates antibiotic was administered daily. (TIF) S11 Fig. PUUV infected ferrets had no infectious virus in the organs.
T26087 56882-56938 Sentence denotes Ferrets were infected with 94,000 PFU PUUV Beaumont i.m.
TextSentencer_T376 56882-56938 Sentence denotes Ferrets were infected with 94,000 PFU PUUV Beaumont i.m.
T43553 56939-57109 Sentence denotes Heart, lung, liver, spleen, kidney, intestine, brain, eye, and adrenal gland were collected on day 35 post infection and assayed for infectious virus by plaque assay (A).
TextSentencer_T377 56939-57109 Sentence denotes Heart, lung, liver, spleen, kidney, intestine, brain, eye, and adrenal gland were collected on day 35 post infection and assayed for infectious virus by plaque assay (A).
T21673 57110-57171 Sentence denotes Virus was spiked in to confirm no inhi bitor was present (B).
TextSentencer_T378 57110-57171 Sentence denotes Virus was spiked in to confirm no inhi bitor was present (B).
T96989 57172-57273 Sentence denotes For a standard plaque assay the limit of detection, 1.7 log 10 , is depicted as a dashed line in (A).
TextSentencer_T379 57172-57273 Sentence denotes For a standard plaque assay the limit of detection, 1.7 log 10 , is depicted as a dashed line in (A).
T84024 57274-57436 Sentence denotes In (B) the mean ± SEM is depicted in all spiked groups and the dashed line is amount of HTNV plaques obtained when spiked into media rather than organ homogenate.
TextSentencer_T380 57274-57436 Sentence denotes In (B) the mean ± SEM is depicted in all spiked groups and the dashed line is amount of HTNV plaques obtained when spiked into media rather than organ homogenate.
T94480 57437-57510 Sentence denotes To confirm no inhibitors were present, virus was spiked into samples (B).
TextSentencer_T381 57437-57510 Sentence denotes To confirm no inhibitors were present, virus was spiked into samples (B).
T53142 57511-57612 Sentence denotes For a standard plaque assay the limit of detection, 1.7 log 10 , is depicted as a dashed line in (A).
TextSentencer_T382 57511-57612 Sentence denotes For a standard plaque assay the limit of detection, 1.7 log 10 , is depicted as a dashed line in (A).
T75044 57613-57784 Sentence denotes In (B) the mean ± SEM is displayed for all spiked groups, and the dashed line is amount of HTNV plaques obtained when spiked into media rather than organ homogenate. (TIF)
TextSentencer_T383 57613-57784 Sentence denotes In (B) the mean ± SEM is displayed for all spiked groups, and the dashed line is amount of HTNV plaques obtained when spiked into media rather than organ homogenate. (TIF)
T34145 57785-57839 Sentence denotes Three marmosets were infected with 1,000 PFU HTNV i.m.
TextSentencer_T384 57785-57839 Sentence denotes Three marmosets were infected with 1,000 PFU HTNV i.m.
T45257 57840-57931 Sentence denotes On Day 30 organs were harvested, and the presence of viral genome was determined by RT-PCR.
TextSentencer_T385 57840-57931 Sentence denotes On Day 30 organs were harvested, and the presence of viral genome was determined by RT-PCR.
T39013 57932-58008 Sentence denotes To confirm no inhibitors were present, viral genome was spiked into samples.
TextSentencer_T386 57932-58008 Sentence denotes To confirm no inhibitors were present, viral genome was spiked into samples.
T60415 58009-58109 Sentence denotes Heart (A), lung (B), liver (C), spleen (D), kidney (E), intestine (F), and brain (G) were collected.
TextSentencer_T387 58009-58109 Sentence denotes Heart (A), lung (B), liver (C), spleen (D), kidney (E), intestine (F), and brain (G) were collected.
T80734 58110-58248 Sentence denotes The mean ± SEM is shown for the not spiked (NS) and spiked (S) groups and the limit of detection, 1 log 10 , is depicted as a dashed line.
TextSentencer_T388 58110-58248 Sentence denotes The mean ± SEM is shown for the not spiked (NS) and spiked (S) groups and the limit of detection, 1 log 10 , is depicted as a dashed line.

CORD-PICO

Id Subject Object Predicate Lexical cue
p1_all0 117-162 Intervention denotes Hantaan virus (HTNV) and Puumala virus (PUUV)
p1_all1 616-625 Outcome denotes Infection
p2_i0 1165-1169 Pharmacological denotes HTNV
p2_o6 1214-1252 Physical denotes seroconversion and gradual weight loss
p1_all2 1214-1252 Outcome denotes seroconversion and gradual weight loss
p2_o6 1261-1314 Physical denotes kidney function remained unimpaired and serum viremia
p1_all3 1301-1348 Outcome denotes serum viremia and viral dissemination to organs
p2_o6 1319-1348 Physical denotes viral dissemination to organs
p2_o8 1540-1556 Physical denotes renal impairment
p1_all4 1540-1604 Outcome denotes renal impairment, serum viremia or viral dissemination to organs
p2_o8 1558-1571 Physical denotes serum viremia
p2_o8 1575-1604 Physical denotes viral dissemination to organs